22 research outputs found
Health Profile of Elderly Persons in Urban and Rural Field Practice Areas of Medical College Himmatnagar, Gujarat
No full textBackground: Care of old age people is becomes a big social problem due to urbanization, nuclearisation of family, migration, and dual career. The objective of this study was to assess socio-demographic condition and health problems among elder people in rural and urban population.
Methods: This cross-sectional study was carried out in RHTC and UHTC of a Medical College in Himmatnagar during Jan to Sept 2016. House to house survey was carried out and 175 elder individual more than 60 years age were included in the study.
Results: 34.9% & 64.6% participants were illiterate and 13.4% % 8.0% were residing alone, 17.2% & 32.6% had restricted mobility, 30.3% & 38.3% had inadequate sleep problems, 22.9% & 27.4% was overweight, higher blood pressure among 57.14% & 37.71%in rural and urban area respectively and mean BMI was 22.9 ± 12.82 & 23.59 ± 4.68 in rural and urban area respectively.
Conclusion: Major requirement for interventions to ensure the health of this susceptible group and to initiate a policy to address the care and needs of the disabled elderly
Perception related to Eye Donation in Science College Students of Himmatnagar City of Gujarat State
No full textBackground: Eye sight is very important for human life. The World Health Organization (WHO) estimates that every 5 seconds someone goes blind. Globally, 37 million people are blind, and of these nearly 10 lakh blind people are willing for corneal transplantation. Awareness and practice of eye donation should be encouraged in community to cop up with this huge demand.
Aims: The aim of the study was to assess the perception regarding eye donation among the science college students as proxy to general population.
Materials and Methods: This is cross sectional study. Data was collected from students of randomly selected science college at Himmatnagar city. Data collected from the participants were analysed using percentage and descriptive statistics.
Results: The participants were well aware of eye donation (93.4%) quoting media as a major source of information for their knowledge. Out of the 334 students, 73.9% were willing to pledge and 26.1% students did not believe in pledging their eyes.
Conclusion: The findings of the study showed that overall knowledge about eye donation among students was good, however relatively less number of students were ready to pledge for eye donation
Housing conditions differentially affect physiological and behavioural stress responses of zebrafish, as well as the response to anxiolytics
No full textPMCID: PMC3324417This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
NRTIs (ZDV and d4T) side effects in PLHAs attending the antiretroviral treatment centre of B. J. Medical College Aad Civil Hospital At Ahmedabad, Gujarat, India
No full textOur experience in second line Anti Retroviral Therapy (ART) At State Aids Clinical Expert Panel (SACEP) Clinic, Centre of Excellence (CoE), Art Centre, B. J. Medical College, Civil Hospital, Ahmedabad
No full textOutcome of first line antiretroviral therapy (art) with respect to treatment Failure at ART CENTRE, B. J. Medical College, Civil Hospital, Ahmedabad
No full textCurrent concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
No full textChronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD
Jatropha curcas biodiesel production in Kenya: economics and potential value chain development for smallholder farmers.
No full textTemporal Changes in Inflammatory Mitochondria-Enriched MicroRNAs Following Traumatic Brain Injury and Effects of miR-146a Nanoparticle Delivery
No full textMicroRNAs (miRNAs) are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular function. We previously reported that the activities of several mitochondria-enriched miRNAs regulating inflammation (i.e., miR-142-3p, miR-142-5p, and miR-146a) are altered in the hippocampus at 3–12 hours following a severe traumatic brain injury. In the present study, we investigated the temporal expression profile of these inflammatory miRNAs in mitochondria and cytosol fractions at more chronic post-injury times following severe controlled cortical impact injury in rats. In addition, several inflammatory genes were analyzed in the cytosol fractions. The analysis showed that while elevated levels were observed in cytoplasm, the mitochondria-enriched miRNAs, miR-142-3p and miR-142-5p continued to be significantly reduced in mitochondria from injured hippocampi for at least 3 days and returned to near normal levels at 7 days post-injury. Although not statistically significant, miR-146a also remained at reduced levels for up to 3 days following controlled cortical impact injury, and recovered by 7 days. In contrast, miRNAs that are not enriched in mitochondria, including miR-124a, miR-150, miR-19b, miR-155, and miR-223 were either increased or demonstrated no change in their levels in mitochondrial fractions for 7 days. The one exception was that miR-223 levels were reduced in mitochondria at 1 day following injury. No major alterations were observed in sham operated animals. This temporal pattern was unique to mitochondria-enriched miRNAs and correlated with injury-induced changes in mitochondrial bioenergetics as well as expression levels of several inflammatory markers. These observations suggested a potential compartmental re-distribution of the mitochondria-enriched inflammatory miRNAs and may reflect an intracellular mechanism by which specific miRNAs regulate injury-induced inflammatory signaling. To test this, we utilized a novel peptide-based nanoparticle strategy for in vitro and in vivo delivery of a miR-146a mimic as a potential therapeutic strategy for targeting nuclear factor-kappaB inflammatory modulators in the injured brain. Nanoparticle delivery of miR-146a to BV-2 or SH-SY5Y cells significantly reduced expression of TNF receptor-associated factor 6 (TRAF6) and interleukin-1 receptor-associated kinase 1 (IRAK1), two important modulators of the nuclear factor-kappaB (NF-κB) pro-inflammatory pathway. Moreover, injections of miR-146a containing nanoparticles into the brain immediately following controlled cortical impact injury significantly reduced hippocampal TNF receptor-associated factor 6 and interleukin-1 receptor-associated kinase 1 levels. Taken together, our studies demonstrate the subcellular alteration of inflammatory miRNAs after traumatic brain injury and establish proof of principle that nanoparticle delivery of miR-146a has therapeutic potential for modulating pro-inflammatory effectors in the injured brain. All of the studies performed were approved by the University of Kentucky Institutional Animal Care and Usage Committee (IACUC protocol # 2014-1300) on August 17, 2017
