1,722,014 research outputs found
Network Meta-Analysis: Evidence Synthesis With Mixed Treatment Comparison
No full textNetwork meta-analyses and mixed treatment comparisons represent the uppermost level in the evidence hierarchy for decision making, in medicine as well as in other scholarly fields. They combine and exploit data from direct (i.e. head-to-head) randomized trials and pool them, when appropriate, with indirect estimates, in order to obtain more precise and robust estimates of effect to determine which management strategy is the safest, most effective, or cost-effective. They have been developed recently thanks to the current widespread availability of high power computers, but have already succeeded in becoming a highly read and impactful type of research design. Several important examples of network meta-analyses with pivotal practical implications are available, spanning from stents for coronary revascularization to psychiatric drugs. This book, the first devoted solely to this topic, aims to cover briefly but poignantly the main topics which should be mastered to critically read and interpret as well as, if deemed worthwhile, perform and report independently a network meta-analysis and mixed treatment comparison. The editorial team represents a veritable Who's Who of worldwide experts in these topics, and everyone involved in the collection has strived to provide correct and sound yet practical advice. This book includes dozens of tables and illustrations to guide visually the reader in understanding the basics as well as the more refined details of network meta-analyses. Quoted references are per se a uniquely useful component of this book, as they provide a commented guidance to the best and most informative papers on mixed treatment comparisons. Thus, this book will be uniquely useful to students or scholars interested in these topics, including clinical researchers and practitioners, as well as statisticians, epidemiologists, psychologists and sociologists
Why interventional cardiologists may be the most suitable specialists for the endovascular management of peripheral artery disease
No full textPeripheral artery disease has a major morbidity and mortality burden worldwide, and its impact is going to increase even further given the obesity and diabetes pandemic. Whereas medical therapy and open surgical therapy (e.g. bypass, endarterectomy, and aneurysmectomy) remain mainstays in the management of peripheral artery disease, endovascular (i.e. percutaneous or transcatheter) therapy is gaining ever increasing success among patients and physicians alike. However, endovascular interventions can be performed by cardiologists, radiologists, vascular surgeons and, possibly, others as well. Are all these specialists similarly likely to perform endovascular procedures in a safe and effective fashion? Can we identify a subset of specialists ideally equipped to perform endovascular interventions in the best manner? We indeed make the case in this article for the possible superiority of interventional cardiologists, for their background, training and clinical experience, in performing endovascular procedures
Minerva cardiology and angiology. Changing while remaining itself in its journey for cardiovascular evidence
No full text
Network Meta-Analyses: The "White Whale" for Cardiovascular Specialists
No full text[No abstract available
Deferred angioplasty and stenting in primary percutaneous coronary intervention: one step back, two steps forward?
No full text[No abstract available
- …
