11,788,852 research outputs found
Abilitazione Scientifica Nazionale - Professore I Fascia- Bando 2012 (DD n. 222/2012)
No full textNON E' UNA PUBBLICAZIONE- ABILITAZIONE SCIENTIFICA NAZIONALE - PROFESSORE I FASCIA- MED06D4- gastroenterologi
C1q-binding donor-specific antibody assays help define risk and prognosis in antibody-mediated rejection
No full textAntibody-mediated rejection represents the first cause of graft loss in renal transplant recipients, and it is imperative to identify appropriate tools to enable risk stratification of such patients. Lately, the usefulness of measuring complement-binding anti–human leukocyte antigen (HLA) donor-specific antibodies (DSAs) in renal transplantation has been intensely debated. While the jury is still out, recent data suggest that monitoring complement-binding DSAs may help to recognize high-risk patients and possibly trigger more effective interventions in selected patients
Le malattie infiammatorie croniche intestinali. In: Manuale di Gastroenterologia. UNIGASTRO. Coordinamento Nazionale Docenti Universitari di Gastroenterologia.
No full text“Biancone”: Giants, Dwarfs, and the Rise of a Popular Nickname
No full textColossal statues like Michelangelo\u27s David were often referred to as “il Gigante” (the Giant), a genre tied to heroic ancient traditions. One Florentine “Gigante,” Bartolomeo Ammannati\u27s Neptune (1560–74) in the Piazza della Signoria, suffered criticism for its aesthetic shortcomings and acquired a popular nickname, “Biancone,” translated as “Big White One” (or “Giant Whitey”). This paper will trace its appearance in Lorenzo Lippi\u27s Il Malmantile Racquistato (1676) where “Biancone” appears as an anti-hero, conquered and subjected to indignities. Lippi\u27s work drew on earlier traditions that celebrated the vulgar, the grotesque, and the carnivalesque, pairing giants and dwarfs for comic effect. As statue and literary character, “Biancone” presents a colorful and humorous case study in the dynamics of Florentine public sculpture
Surgery for inflammatory bowel disease in the era of laparoscopy
No full textDuring the course of inflammatory bowel disease (IBD), surgery may be needed. Approximately 20% of patients with ulcerative colitis (UC) will require surgery, whereas up to 80% of Crohn's disease (CD) patients will undergo an operation during their lifetime. For UC patients requiring surgery, total proctocolectomy and ileoanal pouch anastomosis (IPAA) is the operation of choice as it provides a permanent cure and good quality of life. Nevertheless a permanent stoma is a good option in selected patients, especially the elderly. Minimally invasive surgery has replaced the conventional open approach in many specialized centres worldwide. Laparoscopic colectomy and restorative IPAA is rapidly becoming the standard of care in the treatment of UC requiring surgery, whilst laparoscopic ileo-cecal resection is already the new gold standard in the treatment of complicated CD of terminal ileum. Short term advantages of laparoscopic surgery includes faster recovery time and reduced requirement for analgesics. It is, however, in the long term that minimally invasive surgery has demonstrated its superiority over the open approach. A better cosmesis, a reduced number of incisional hernias and fewer adhesions are the long term advantages of laparoscopy in IBD surgery. A reduction in abdominal adhesions is of great benefit when a second operation is needed in CD and this influences positively the pregnancy rate in young women undergoing restorative IPAA. In developing the therapeutic plan for IBD patients it should be recognized that the surgical approach to the abdomen has changed and that surgical treatment of complicated IBD can be safely performed with a true minimally invasive approach with great patient satisfaction
Role of L-selectin in the vascular homing of peripheral blood-derived endothelial progenitor cells
No full textEx vivo expanded endothelial progenitor cells (EPCs) represent a new potential approach for the revascularization of ischemic sites. However, local accumulation of infused EPCs in these sites is poor, and the mechanisms responsible for their homing are largely unknown. We observed the expression of L-selectin, an adhesion receptor that regulates lymphocyte homing and leukocyte rolling and migration, on ex vivo expanded blood-derived human EPCs. When EPCs were subcloned in SV40-T large Ag-transfected isolates, the copresence of L-selectin and endothelial lineage markers was confirmed. We therefore demonstrated that the expression of L-selectin by EPCs was functional because it mediates interaction with a murine endothelial cell line (H.end) expressing L-selectin ligands by way of transfection with alpha(1,3/4)-fucosyltransferase. Indeed, adhesion of EPCs after incubation at 4 degrees C on a rotating platform was enhanced on alpha(1,3/4)-fucosyltransferase-transfected H.end cells compared with control vector-transfected cells, and treatment with anti-L-selectin Abs prevented this event. We then studied the role of L-selectin in EPC homing in vivo. H.end cells were implanted s.c. in SCID mice to form endothelioma tumors, and EPCs were subsequently i.v. injected. L-selectin+ EPCs localized into alpha(1,3/4)-fucosyltransferase-transfected endothelial tumors to a greater extent than in control tumors, and they were able to directly contribute to tumor vascularization by forming L-selectin+ EPC-containing vessels. In conclusion, our results showed that a mechanism typical of leukocyte adhesion is involved in the vascular homing of EPCs within sites of selectin ligand expression. This observation may provide knowledge about the substrate to design strategies to improve EPC localization in damaged tissues
Tc-99m HMPAO-labeled leukocyte scintigraphy with hybrid SPECT/CT detects perianal fistulas in Crohn disease
No full textScintigraphy with Tc-99m HMPAO-labeled leukocytes proved useful to diagnose intestinal lesions in Crohn disease (CD). The hybrid device combining single photon emission tomography (SPECT) and computed tomography (CT) has been reported to improve SPECT diagnostic accuracy matching functional and anatomic information. The authors describe a 30-year-old man with ileorectal anastomosis for CD. In this case, SPECT shows an area of leukocyte accumulation within the pelvis, and SPECT/CT precisely localizes this uptake along a perianal fistulous tract. This image indicates the usefulness of the hybrid SPECT/CT device to assess the site and the extent of CD lesions within the pelvic floor. Copyright © 2006 by Lippincott Williams & Wilkins
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