1,237 research outputs found
Facing the Future: the Changing Shape of Academic Skills Support at Bournemouth University
No full textThis paper explores the potential impact of changes to higher education in England on student expectations, engagement, lifestyles and diversity, and outlines implications for the development of digital literacy within academic skills support at Bournemouth University (BU). We will investigate how tackling resource constraints with organisational change can also enable efficient, centralised provision of support materials that utilise networks to overcome the risk of fragmented support for digital literacy. We will also look at how changing delivery modes for support can accommodate changing student lifestyles whilst tackling a weakness of centralised support for digital literacy: that it can become detached from the student’s subject-focused academic practice. Finally we will explore how involving students in developing support can help us to face changes to student expectations and engagement whilst ensuring that materials are authentic and speak to learners in their own voice
Maximizing Research Impact Through Institutional and National Open-Access Self-Archiving Mandates
No full textNo research institution can afford all the journals its researchers may need, so all articles are losing research impact (usage and citations). Articles made “Open Access,” (OA) by self-archiving them on the web are cited twice as much, but only 15% of articles are being spontaneously self-archived. The only institutions approaching 100% self-archiving are those that mandate it. Surveys show that 95% of authors will comply with a self-archiving mandate; the actual expe-rience of institutions with mandates has confirmed this. What institutions and funders need to mandate is that (1) immediately upon acceptance for publication, (2) the author’s final draft must be (3) deposited into the Institutional Repository. Only the depositing needs to be mandated; set-ting access privileges to the full-text as either OA or Restricted Access (RA) can be left up to the author. For articles published in the 93% of journals that have already endorsed self-archiving, access can be set as OA immediately; for the remaining 7%, authors can email the eprint in re-sponse to individual email requests automatically forwarded by the Repository
Treatment of triple-negative breast cancer with TORC1/2 inhibitors sustains a drug-resistant and notch-dependent cancer stem cell population
No full textApproximately 30% of triple-negative breast cancers (TNBC) harbor molecular alterations in PI3K/mTOR signaling, but therapeutic inhibition of this pathway has not been effective. We hypothesized that intrinsic resistance to TORC1/2 inhibition is driven by cancer stem cell (CSC)-like populations that could be targeted to enhance the antitumor action of these drugs. Therefore, we investigated the molecular mechanisms by which PI3K/mTOR inhibitors affect the stem-like properties of TNBC cells. Treatment of established TNBC cell lines with a PI3K/mTOR inhibitor or a TORC1/2 inhibitor increased the expression of CSC markers and mammosphere formation. A CSC-specific PCR array revealed that inhibition of TORC1/2 increased FGF1 and Notch1 expression. Notch1 activity was also induced in TNBC cells treated with TORC1/2 inhibitors and associated with increased mitochondrial metabolism and FGFR1 signaling. Notably, genetic and pharmacologic blockade of Notch1 abrogated the increase in CSC markers, mammosphere formation, and in vivo tumor-initiating capacity induced by TORC1/2 inhibition. These results suggest that targeting the FGFR-mitochondrial metabolism-Notch1 axis prevents resistance to TORC1/2 inhibitors by eradicating drug-resistant CSCs in TNBC, and may thus represent an attractive therapeutic strategy to improve drug responsiveness and efficacy
Hearing Faces and Seeing Voices: The Integration and Interaction of Face and Voice Processing
No full textCognitive understanding of voice recognition has borrowed much from the area of face processing, both in terms of the theoretical framework within which results are interpreted, and the methodology used to assess performance. A considerable body of research now exists to suggest that voice recognition may proceed in parallel with face recognition, and that the two pathways may combine to inform person recognition. However, rather than being independent or equivalent, these parallel pathways appear to interact to reveal interesting interference effects. The present paper reviews a series of studies that focus on a considerable and growing literature. The vulnerability of voice processing will be explored relative to face processing, and the interaction of these two pathways will be examined with reference to broader theoretical frameworks for person recognition
Discussion of Neil Altman's paper, ‘psychoanalysis and war’
No full textThis paper consists of a discussion of Neil Altman's ‘Psychoanalysis and war’, which was conducted online through PsyBC in the fall of 2006. Discussants were a group of psychoanalytically oriented thinkers chosen by the author and Nancy Hollander, the author of the other paper included in the discussion. The paper represents the full discussion with only minor edits to correct typographical errors and improve clarity
Dissimilarity is used as evidence of category membership in multidimensional perceptual categorization: a test of the similarity-dissimilarity generalized context model
No full textIn exemplar models of categorization, the similarity between an exemplar and category members constitutes evidence that the exemplar belongs to the category. We test the possibility that the dissimilarity to members of competing categories also contributes to this evidence. Data were collected from two 2-dimensional perceptual categorization experiments, one with lines varying in orientation and length and the other with coloured patches varying in saturation and brightness. Model fits of the similarity-dissimilarity generalized context model were used to compare a model where only similarity was used with a model where both similarity and dissimilarity were used. For the majority of participants the similarity-dissimilarity model provided both a significantly better fit and better generalization, suggesting that people do also use dissimilarity as evidence
Millisecond accuracy video display using OpenGL under Linux
No full textTo measure people’s reaction times to the nearest millisecond, it is necessary to know exactly when
a stimulus is displayed. This article describes how to display stimuli with millisecond accuracy on a
normal CRT monitor, using a PC running Linux. A simple C program is presented to illustrate how this
may be done within X Windows using the OpenGL rendering system. A test of this system is reported
that demonstrates that stimuli may be consistently displayed with millisecond accuracy. An algorithm
is presented that allows the exact time of stimulus presentation to be deduced, even if there are relatively
large errors in measuring the display time
La causa de la democracia post-soviética. Historias. Revista de la Dirección de Estudios Históricos. Num. 85 (2013) mayo-agosto
No full textNeil Buckley realizó estudios de letras rusas y francesas en el University College de la Universidad de Oxford. Trabaja desde 1991 en el Financial Times, en donde se ha hecho cargo de muy diversas secciones y tareas, entre ellas la de titular de la oficina de Moscú, y en la actualidad es el editor para asuntos de Europa oriental. Tomado del Financial Times del 19 de agosto de 2011
Introduction: the unknown Alasdair MacIntyre and a note on the selection and annotation
No full textAlthough Alasdair MacIntyre is best known today as the author of After Virtue (1981), he was, in the 1950s and 1960s, one of the most erudite members of Britain's Marxist Left. This introduction discusses the unknown Alasdair MacIntyre
The Total Synthesis of Dragmacidins D and F
No full textThe dragmacidins are an emerging class of bis(indole) natural products isolated from deep-water marine organisms. Although there has been a substantial effort to prepare the simple piperazine dragmacidins, little synthetic work has been done in the area of the pyrazinone-containing family members, dragmacidins D, E, and F. These compounds are particularly interesting due to their complex structures and broad range of biological activity.
A highly convergent strategy to access dragmacidin D has been developed. In this approach, sequential halogen-selective Suzuki couplings were used to assemble the carbon scaffold of the natural product. After executing a highly optimized sequence of final events, the first completed total synthesis of dragmacidin D was achieved.
An enantiodivergent strategy for the total chemical synthesis of both (+)- and (-)-dragmacidin F from a single enantiomer of quinic acid has been developed and successfully implemented. Although unique, the synthetic routes to these antipodes share a number of key features, including novel reductive isomerization reactions, Pd(II)-mediated oxidative carbocyclization reactions, halogen-selective Suzuki couplings, and high-yielding late-stage Neber rearrangements.
The formal total syntheses of dragmacidin B, trans-dragmacidin C, and dihydrohamacanthin A are described. In addition, preliminary studies involving a novel approach for the preparation of dragmacidin E are reported.</p
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