20 research outputs found
JUNK FOOD: IMPACT ON HEALTH
No full textJunk refer to fast food which are easy to make and easy to consume. Michael Jacobson aptly coins the phrase junk food in 1972 as slang for foods of useless or low nutritional value. Junk food so called HFSS (High fat, sugar or salt). Various type of Junk food that available in restaurants is cold-drinks, pizza, burger, and sandwich etc. The number of fast food restaurants and chain is increasing because people around the world like to eat junk food .USA, Canada, Britain, Australia, Japan, Sweden etc. are the countries with most junk food consumption around the world. Junk food is more popular because of experience of great taste, better shelf life and easy transportation. The junk food advertising is also play a great role in junk food’s popularity. But it should be avoided, because of lack of energy, high cholesterol and poor concentration. It causes a lot of harmful effect on the body like obesity, diabetes, heart disease and various types of skin cancers. Eliminating the temptation for junk food and developing the awareness for fitness can be helping in avoid the junk food from the healthy diet regimen. Key Words: - junk food, cholesterol, obesity, burger, pizza
NANOCRYSTAL SUSPENSION OF CEFIXIME TRIHYDRATE PREPARATION BY HIGH-PRESSURE HOMOGENIZATION FORMULATION DESIGN USING 23 FACTORIAL DESIGN
No full textObjective: In the present study, nanocrystal suspensions of cefixime trihydrate were prepared with the objective of providing increased solubility and stability with their nanoscopic size and thus developing the formulation of enhanced bioavailability potential.Methods: Nanocrystal suspensions were prepared by high-pressure homogenization technique using PVP K-30 as a stabilizer and evaluated for particle size, polydispersity index, zeta potential, permeation and drug release.Results: Particles of average size 143.5 nm having a polydispersity index of 0.269 were produced. Zeta potential was found to be −36.6 mV and the formulation was found stable on the basis of results obtained from differential scanning calorimetry and Fourier transform infrared spectroscopy studies. Optimized formulation showed 89.79 % and 88.38% drug lease and permeation respectively.Conclusion: The drug release and ex-vivo permeation studies revealed enhanced permeation of drug, as desired, indicating its potential for an attempt towards successful nano crystal formulation.</jats:p
NANOCRYSTAL SUSPENSION OF CEFIXIME TRIHYDRATE PREPARATION BY HIGH-PRESSURE HOMOGENIZATION FORMULATION DESIGN USING 23 FACTORIAL DESIGN
No full textObjective: In the present study, nanocrystal suspensions of cefixime trihydrate were prepared with the objective of providing increased solubility and stability with their nanoscopic size and thus developing the formulation of enhanced bioavailability potential.Methods: Nanocrystal suspensions were prepared by high-pressure homogenization technique using PVP K-30 as a stabilizer and evaluated for particle size, polydispersity index, zeta potential, permeation and drug release.Results: Particles of average size 143.5 nm having a polydispersity index of 0.269 were produced. Zeta potential was found to be −36.6 mV and the formulation was found stable on the basis of results obtained from differential scanning calorimetry and Fourier transform infrared spectroscopy studies. Optimized formulation showed 89.79 % and 88.38% drug lease and permeation respectively.Conclusion: The drug release and ex-vivo permeation studies revealed enhanced permeation of drug, as desired, indicating its potential for an attempt towards successful nano crystal formulation
A REVIEW ON FORMULATION APPROACHES IN IMMEDIATE RELEASE TABLET
No full textSometimes immediate onset of action is required than conventional treatment in many patients. Among all dosage forms tablet is the most popular dosage form existing today because of its convenience of self-administration, compactness and easy manufacturing. to overcome these drawbacks, immediate release dosage form has emerged as alternative oral dosage forms. Immediate drug release dosage forms disintegrate quickly after administration with enhanced rate of dissolution. The basic approach used in development tablets is the use of superdisintegrants like Cross linked Polyvinylpyrrolidone or crospovidone (Polyplasdone), Sodium starch glycolate (Primogel, Explotab), carboxymethylcellulose (Croscarmellose) etc. In this field immediate release liquid dosage forms and parenteral dosage form have also been introduced for treating patients. The development of immediate release therapy also provides an opportunity for a line extension in the marketplace, a wide range of drugs e.g., anticoagulant and other drugs can be considered candidates for this dosage form. The development of immediate release therapy also provides an opportunity for a line extension in the marketplace, a wide range of drugs e.g., anticoagulant and other drugs can be considered candidates for this dosage form. Keywords: Immediate release, super disintegrates, direct compression, wet GranulationÂ
LIQUID CRYSTALLINE DRUG DELIVERY SYSTEM FOR SUSTAINED RELEASE LOADED WITH AN ANTITUBERCULAR DRUG
No full textIn present study, LCs were formulated and evaluate for desirable properties, Sonication conditions were firstly investigated to determine their effects on the morphological and dimensional characteristics of liquid crystals and optimized according probe sonication condition (Ultra Tarrux T25), liquid crystals with reproducible narrow particle size distribution and mean particle size of 168.0 ± 2.1 nm were obtained. The structure of the dispersed cubosomes was revealed by XRD (X-ray diffraction) and SEM (scanning electron microscopy) as a liquid crystalline phase. To overcome the dose frequency and increase drug loading rate, in vitro-dissolution, method, ultracentrifuge be firstly develop liquid crystals containing Rifampicin. The encapsulation efficiency determined by UV spectroscopy was 93.86 ± 0.11% and stability studies in pH 6.8 phosphate buffer solutions further confirmed that Rifampicin was successfully encapsulated in liquid crystals. Keywords: Cubic phases, liquid crystals, GMO, Rifampicin, high speed homogenization (Ultra Tarrux T25), probe sonication
DISPERSION PROCESS: ROLE IN THE FORMULATION OF PARTICULATE DISPERSE SYSTEM OF POORLY SOLUBLE DRUGS
No full textAs significant number of products manufactured for personal care/health care, either in the final stage or at some stage of their production, dispersion of particulate materials dispersed into liquid or solid vehicles, often at high volume fraction. The vast array of cosmetics/personal care and pharmaceutical products reveal the importance of adequate dispersion. With active pharmaceutical ingredients possessing poor aqueous solubility, optimal dispersion is necessary for maximizing the bioavailability and uniformity of dose. Fine particulate dry powders always contain agglomerates that require de-agglomeration and stabilization to obtain optimal dispersion. All particulate dispersion systems are inherently thermodynamically unstable. Unless properly stabilized, through the random motion of the particles over time, they will get aggregate due to the natural and dominant tendency to decrease the large specific surface area and excess surface energy. Adequate concentrations of wetting agents, de-agglomerating agents and stabilizers are required to produce stable particulate dispersions. The dispersion process is accomplished via three distinct steps: wetting the particulate material, de-agglomeration of the particles and stabilization of the same, and these steps should be performed in the correct order to get a stable product. Key words: de-agglomeration, stabilization, Ostwald ripening, particulate dispersion, aggregates
ROLE OF STABILIZERS IN NANOSUSPENSION – A REVIEW
No full textThe Main goal of surfactants in the formation of nanoparticles is due to its high effect on the dispersion. Nano-suspension, as non- crystal systems, present characteristics and properties which depend not only on composition but also on the preparation method. Although interest in nano-Suspension was developed since about 20 years ago, mainly for nanoparticle preparation, it is in the last years that direct applications of nano-suspension in consumer products are being developed, mainly in pharmacy, drugs, personal care, health care, agrochemicals and cosmetics. These recent applications have made that studies on optimization methods for nano- suspension preparation be a requirement. This review is focused on the most recent literature on developments of nano-suspension as final application products and on the optimization of their preparation.
Keywords: Nano-suspension, Stabilizers, Role, Techniques, Advantages, Disadvantage
BIOANALYTICAL METHOD DEVELOPMENT AND METHOD VALIDATION IN HUMAN PLASMA BY USING LC MS/MS
No full textBioanalytical method development plays importance role in the pre-clinical and clinical studies. Pharmacokinetics of any drug and its metabolite can be recognized by bioanalytical studies. The quantitative analysis of drugs and their metabolite sin the biological media is done by bioanalytical studies. Physical-chemical and biological techniques are used for these studies. Every bioanalytical method should be selective, sensitive and reliable for the quantitative estimation in drug discovery process. Bioanalytical method development consists of sample preparation, chromatographic separation and detection by using proper analytical method. Each developed method should be validated as per the regulatory authorities, so as to give reliable and reproducible method for the intended use. Many analytical techniques can be used for bioanalysis; LCMS/MS is one of them. In Liquid chromatography-mass spectrometry [LC-MS/MS] the separation of analyte is done by LC and detection is carried out by MS. LC-MS/MS obviously used in estimation and understanding of bioavailability, bioequivalence and pharmacokinetic data. This review additionally centered on different validation parameters such as: accuracy, precision, sensitivity, selectivity, standard curve, limits of quantification, range, recovery stability, etc.
Keyword: Solid phase extraction, Liquid-Liquid Extraction, cartridge, LC MS/MS, Bioanalysis, Validation
The Evolution of Nanocrystalline Drug Delivery System
No full textDeveloping nanocrystalline drug delivery technologies is a noteworthy advancement in pharmaceutical science. The nanocrystalline formulations aim to improve therapeutic efficacy, pharmaceutical solubility, and bioavailability. We develop many methods for their fabrication, with top-down, bottom-up, and combination procedures, beginning with reasoning behind nanocrystalline approaches. In this type of review, we focused on the progress of nanocrystalline drug delivery systems in various years by applying different techniques which started in 1990 and what dosage forms are still made by this technology. It is found that various other techniques are also there manufacturing of drug Nanocrystals through years of investigation made by specialists. The researchers found methods such as Top-down, bottom-up, combination, solvent displacement technology, fluidised bed technology, freeze drying, spray drying, electrodynamic technique, and melt emulsification. Every process has advantages and disadvantages, therefore selecting the proper technology is critical to produce drug nanocrystals successfully.
Keywords: Nanocrysyals, CT, Bottom-up, Top-Down, HPH, Nanocarrier
