1,355,251 research outputs found
Recording of Interview with Jurjen Beumer
No full textBeumer was Director and Pastor of Oecumenisch Diaconaal Centrum Stem in de Stad in the Netherlands, or Voice in the City, a religious-based welcoming house for people in distress. Beumer wrote the biography 'The Spirituality of Henri Nouwen' published in 1996. Beumer died on June 4, 2013.1 audio cassette (1 hr. 34 mins.)Title based on contents of the item. ; The interview is transcribed and is available electronically and in hard copy. All transcriptions and recordings are in Dutch. ; Located in audio cassettes box 10. ; Reference copies of the audio cassettes are available (located with original). ; No publication of this material, in whole or in part, without the permission of the Archivist. ; Digitized January 28, 2011.For more information please contact Special Collections, the University of St. Michael's College.Item consists of one cassette of an interview with Jurjen Beumer conducted by Peter Naus in Haarlam, The Netherlands
Listeria monocytogenes : detection and behaviour in food and in the environment
No full textIn this thesis, Listeria monocytogenes, a bacterial pathogen was studied, with emphasis on the detection and behaviour in food and environment.Epidemics of foodborne listeriosis have raised concern about the incidence of L. monocytogenes in foods. In the past 10-15 years listeriosis has emerged as a foodborne illness in a series of large outbreaks from contaminated milk, coleslaw, soft cheese and paté. The organism is ubiquitous in the environment and has been isolated from a variety of raw and ready-to-eat food products.As there is a lack of reliable enrichment procedures, factors influencing the isolation, confirmation and identification of L. monocytogenes were investigated. It was shown that the other (faster growing) listerias can mask the presence of this pathogen in enrichment media. The use of lithium chloride did not overcome this effect. It was also observed that the use of acriflavine in enrichment media affected the isolation of L. monocytogenes both directly and indirectly. Because these effects will lead to inferior detection of L. monocytogenes, it is worthwhile to introduce an isolation medium on which the pathogen can be differentiated from non-pathogenic listerias. On enhanced hemolysis agar (EHA), L. monocytogenes can be distinguished from other listerias on the basis of hemolysis.The traditional methods for the detection of L. monocytogenes are both time consuming and labour intensive. Therefore, rapid test kits for Listeria and L. monocytogenes have been developed. Differences among the various test kits may be contributed to the enrichment protocols, the detection limits of the tests and the concentration of Listeria cells in the samples.In the second part of this thesis, the behaviour of L. monocytogenes in food and environment was investigated.In the literature contradictory results on the growth of the organism on meat surfaces have been reported. In this study it was shown that growth on raw meat was strain dependent and mainly determined by initial pH and storage temperature. On cooked meat products the growth was not or only slightly affected by the storage atmosphere and the presence of lactic acid bacteria. At the end of shelf life, levels of 10 7cfu per g could be reached.Under osmotic stress conditions exogenously added proline, betaine and carntine significantly stimulate growth in laboratory media. Because these compounds are also present in foods, they can contribute to growth of L. monocytogenes in various foods at high osmolarities.In sporadic cases of listeriosis it is often difficult to link food products with this disease, unknown sources may also be responsible for illness. From an investigation in the domestic environment it became clear that L. monocytogenes may be present in high numbers.To be able to control the problems caused by L. monocytogenes, international microbiological criteria, based on 2L. monocytogenes cells per gram on sell-by-date should be established. Persons at risk (immuno-compromized, pregnant) should be strongly advised not to eat food products likely to contain the pathogen. Meanwhile, more attention should be given to challenge studies, factory ecology, cleaning and disinfection and both personal and domestic hygiene
FUNDAMENTALS OF IMPLANT DENTISTRY VOL II: SURGICAL PRINCIPLES
No full textSince the concept of osseointegration was introduced to the dental community more than 35 years ago by Professor P-I Brånemark, significant improvements have been achieved in patient evaluation, methods used to enhance the bone and soft tissues of potential implant sites, and surgical techniques to prepare the osteotomy sites and place the implants. These topics are thoroughly discussed from the perspective that an interdisciplinary approach will yield the most predictable outcomes for treatment of the dental implant patient. The authors address the sometimes controversial topic of immediate loading and provide useful insights regarding when this approach can achieve predictable outcomes and when it is to be avoided. The use of CAD/CAM technologies is emphasized throughout the text, and the latest developments and their use in this rapidly expanding arena are fully described
Phenotypic and genotypic characterization of sorbitol-negative of slow-fermenting (suspected O157) Escherichia coli isolated from milk samples in Lombardy region
No full textAims: To investigate phenotypic and genotypic aspects of sorbitol-negative or slow-fermenting Escherichia coli, suspected to belong to O157 serogroup, isolated in Italy. Methods and Results: Milk samples originating from goats and cows were screened for the presence of E. coli O157 with cultural methods. Sorbitol-negative or slow-fermenting strains were subjected to phenotypic characterization, antibiotic resistance profiles, PCR reactions for detection of toxins (stx(1) and stx(2)) and intimin (eae(GEN) and eae(O157)) genes and clustering by pulsed field gel electrophoresis (PFGE). Only one strain revealed to be O157. Susceptibility to 11 antibiotics highlighted the high resistance to tetracycline (50%), sulfonamide and streptomycin (33%). The stx(2) gene was detected in two strains; only the strain identified as O157 exhibited an amplicon for both eae genes. PFGE identified seven distinct XbaI macrorestriction patterns at a similarity level of 41%. Conclusions: The use of sorbitol fermentation as cultural method is not sufficient for STEC discrimination while PCR assay proved to be a valuable method. Significance and Impact of the Study: The study reports presence of Shiga toxin-producing E. coli in raw milk, signalling a potential risk for humans
Hygieia. Identity, Cult and Reception
No full textThis article examines the Greek goddess Hygieia by looking at her identity, cult status in the ancient world and subsequent scholarly reception. Should she be viewed as a goddess or a personification? By studying Hygieia primarily as a concept of health within ancient medicine, as well as a personification and a goddess, it will be argued that religious and mythological figures should be viewed as deities within ancient Greek culture, rather than personifications. The article will consider Hygieia’s role in the cult of Asklepios and examine whether she is of greater importance because of her function as a goddess of healing, as well as discussing her role within emergent Christianity
Gerard Lukken herzien. Van inculturatie naar culturatie en weer terug. Een pleidooi voor een Lukken-Hoondert model
No full textThis article argues for a critical evaluation of Gerard Lukken’s concept of inculturation, which he tried to adapt to culturation, but still returned to inculturation asdominant concept. Further it will be argued that Lukkens' model is obsolete and sould therefore be adapted into a new concept: the Lukken-Hoondert model
Unusual cause of gastrointestinal bleeding: multiple small bowel carcinoid tumours
No full textImages for SurgeonsAaron M. Thomas, Jesse D. Beumer, Aravind Suppiah and Peter G. Devit
BluePrInt study: Unintended pregnancy and mental health
No full textThe baseline cohort of the BluePrInt study consists of around 1031 people who experienced an unintended pregnancy in the Netherlands: 638 womxn (382 continued the pregnancy (CT), 256 had an abortion ((AB)) and 273 partners CTgroup: 142, AB-group: 131). CT participants completed the questionnaire around 14 weeks gestation. The majority of AB participants had a first trimester abortion (89.8%), and filled out the questionnaire afterwards. A second questionnaire was administred one year later, and was filled out by 55% of participants. Further, additional in-depth interviews were conducted with 60 participants.
The BluePrInt study was designed to investigate mental health consequences of unintended pregnancy. Data contains info on the degree of pregnancy unintendedness, mental health, social support, partner involvement, items related to the decision-making process, contraceptive behavior, care experiences and child development (in the case the unintended pregnancy was carried to term)
Pharmacology and pharmacokinetics of tazemetostat
No full textTazemetostat, a novel oral selective inhibitor of enhancer of zeste homolog 2 (EZH2), was approved by the Food and Drug Administration (FDA) in 2020 for use in patients with advanced epithelioid sarcoma or relapsed/refractory (R/R) EZH2-mutated follicular lymphoma. These indications were approved by the FDA trough accelerated approval based on objective response rate and duration of response that resulted from phase 2 clinical trials. Tazemetostat competes with S-adenosylmethionine (SAM) cofactor to inhibit EZH2, reducing the levels of trimethylated lysine 27 of histone 3 (H3K27me3), considered as pharmacodynamic marker. Tazemetostat is orally bioavailable, characterized by rapid absorption and dose-proportional exposure, which is not influenced by coadministration with food or gastric acid reducing agents. It highly distributes in tissues, but with limited access to central nervous system. Tazemetostat is metabolized by CYP3A in the liver to 3 major inactive metabolites (M1, M3, and M5), has a short half-life and is mainly excreted in feces. Drug-drug interactions were shown with moderate CYP3A inhibitors as fluconazole, leading the FDA to recommend a 50% dose reduction, while studies investigating coadministration of tazemetostat with strong inhibitors/inducers are ongoing. No dosage modifications are recommended based on renal or hepatic dysfunctions. Overall, tazemetostat is the first-in-class EZH2 inhibitor approved by the FDA for cancer treatment. Current clinical studies are evaluating combination therapies in patients with several malignancies
A MAP approach to landmarking
No full textLandmarking can be seen as calculating the maximum a posteriori probability of a certain set of landmarks given a certain image (texture) which contains a face. The MLLL plus BILBO algorithm by Beumer et al [1] is one method. An improvement to this existing landmarking algorithm, MLLL in combination with BILBO, is presented. MLLL uses a likelihood ratio based similarity score to mark candidate landmark locations. BILBO uses a statistical method on the shape to correct outliers. A theoretical analysis of this intuitive approach shows new insight. In order to verify this theory we performed a simple experiment. The results show that using the new method performs significantly better than when only using the similarity score method (MLLL) in combination with outlier removal (BILBO)
- …
