2,816 research outputs found
Human fibroblast and human bone marrow cell response to lithographically nanopatterned adhesive domains on protein rejecting substrates
No full textThe separate influence of topographical and chemical cues on cell attachment and spreading are well documented; however, that of duel-cue substrates is less so. In this study graft copolymers that sterically stabilize biological surfaces were employed alongside nanotopographical features fabricated by colloidal lithography. This resulted in the production of a range of substrates whereby the effect of chemistry and or topography on both on human fibroblast and bone marrow cell adhesion and spreading could be observed. The current studies indicate an enhancement of cell response as a consequence of modifications in material topography, whereas the current selected chemical cues inhibited cell function. Critically, in combination, topography modulated the effects of chemical environment
FellWalker - a clump identification algorithm
No full textAbstractThis paper describes the FellWalker algorithm, a watershed algorithm that segments a 1-, 2- or 3-dimensional array of data values into a set of disjoint clumps of emission, each containing a single significant peak. Pixels below a nominated constant data level are assumed to be background pixels and are not assigned to any clump. FellWalker is thus equivalent in purpose to the CLUMPFIND algorithm. However, unlike CLUMPFIND, which segments the array on the basis of a set of evenly-spaced contours and thus uses only a small fraction of the available data values, the FellWalker algorithm is based on a gradient-tracing scheme which uses all available data values. Comparisons of CLUMPFIND and FellWalker using a crowded field of artificial Gaussian clumps, all of equal peak value and width, suggest that the results produced by FellWalker are less dependent on specific parameter settings than are those of CLUMPFIND
New (Probabilistic) Derivation of Diaz-Metcalf and Pólya-Szegő Inequalities and Consequences
No full textClassical inequalities of Diaz - Metcalf and Pólya - Szegő are generalized to
probabilistic setting which covers the initial deterministic (both discrete and integral) variants.
From these two inequalities, by the probabilistic derivation method further well -
known inequalities are obtained (that ones by Kantorovich, Rennie and Schweitzer)
Mouvance and the medieval author: re-editing Ancrene Wisse
No full textThe paper discusses the theoretical and practical problems of editing the early thirteenth-century guide for anchoresses, Ancrene Wisse, which (in Paul Zumthor's phrase) is an 'oeuvre mouvante', modified repeatedly from an early stage by its author and others
Tele-operated climbing and mobile service robots for remote inspection and maintenance in nuclear industry
No full textD.S. Merezhkovsky and C.G. Jung: General and Special
No full textВ статье рассмотрены особенности трактовки символа в творчестве Д.С. Мережковского и К.Г. Юнга. Показано влияние идей Мережковского на формирование воззрений К.Г. Юнга, проведен сопоставительный анализ их концепций символа как многозначной и универсальной категории, подчеркнуто значение творчества мыслителей для интерпретации исторических событий и осмысления современной общественной ситуации.The article describes the features of the interpretation of the symbol in the works of D.S. Merezhkovsky and K.G. Jung. The author focuses the attention on the influence Merezhkovsky's ideas on the formation of views of Jung, conducted a comparative analysis their conceptions of symbolism as a multi–valued and universal category, stressed the importance thinkers’ works for the interpret historical events and understanding the contemporary social situation
Fully localised edge states in boundary layers
No full textInvestigation of the laminar-turbulent boundary is performed in a boundary-layer flow. Constant homogeneous suction is applied at the wall in order to prevent the spatial growth of the layer, leading to the parallel Asymptotic Suction Boundary Layer (ASBL). Edge tracking is performed in a large computational domain allowing for full spatial localisation of the structures on the laminar-turbulent separatrix. The obtained dynamics of the state goes through calm and bursting phases. During the latter the structure grows in size, shedding vortices downstream of its core which viscously decay during the calm phases. Comparison with the computation in spatially growing boundary layer is made. The influence of the Reynolds number and the path leading from the edge state to turbulent flow are considered
Bypass transition in boundary layers as an activated process
No full textWe consider the spatio-temporal aspects of the transition to turbulence in a boundary layer above a flat plate exposed to free-stream turbulence. Combining results from the receptivity to free-stream turbulence with the observation of a double threshold from transition studies in e.g. pipe flow we arrive at a physically motivated prediction for the spatial distribution of nucleation events in boundary layers. We use a cellular automaton to implement a complete model for the spatial and temporal evolution of turbulent patches and show that the model reproduces the statistical features of the boundary layer remarkably well. The success of the modeling shows that bypass transition occurs as a spatiotemporally activated process, where transition is triggered by critical fluctuations imported from the free-stream turbulence
A regional, multi-sectoral and integrated assessment of the impacts of climate and socio-economic change in the UK: Part I. Methodology
No full textPolicy makers and stakeholders are increasingly demanding impact assessments
which produce policy-relevant guidance on the local impacts of global climate
change. The 'Regional Climate Change Impact and Response Studies in East Anglia
and North West England' (RegIS) study developed a methodology for stakeholder-
led, regional climate change impact assessment that explicitly evaluated local
and regional (sub-national) scale impacts and adaptation options, and cross-
sectoral interactions between four major sectors driving landscape change
(agriculture, biodiversity, coasts and floodplains and water resources). The
'Drivers-Pressure-State-Impact-Response' (DPSIR) approach provided a structure
for linking the modelling and scenario techniques. A 5x5 km grid was chosen for
numerical modelling input (climate and socio-economic scenarios) and output, as
a compromise between the climate scenario resolution (10x10 km) and the detailed
spatial resolution output desired by stakeholders. Fundamental methodological
issues have been raised by RegIS which reflect the difficulty of multi-sectoral
modelling studies at local scales. In particular, the role of scenarios, error
propagation in linked models, model validity, transparency and transportability
as well as the use of integrated assessment to evaluate adaptation options to
climate change are examined. Integrated assessments will provide new insights
which will compliment those derived by more detailed sectoral assessments
[Interview Minutes with D.S. Myer, WRA National Director, March 18, 1944]
No full textMeeting minutes between incarceree-led Tule Lake Camp government and War Relocation Authority Director D.S. [Dillon Seymour] Myer. Question-answer session between Co-ordinating Committee and Myer. Includes questions about legitimacy and self-governance of Co-ordinating Committee, concerns about camp food, employment, and martial law in the camp.The Willard Schmidt collection, documents some of the administrative duties of Willard Schmidt, the Chief of Internal Security for the War Relocation Authority and the Tule Lake incarceration/segregation camp. This collection contains administrative records and photos documenting the Tule Lake camp, the largest incarceration camp with a peak population of 18,789 and with the most turbulent history. In 1943, the camp was turned into a segregation center to house "disloyal" Japanese Americans relocated from other camps based on their answers to a confusing loyalty questionnaire. The camp endured martial law from November 1943- Jan 1944 after escalating protests and unrest. The hostile environment of the camp lead to many incarcerees renouncing their American citizenship upon the end of incarceration, a process which took 14 years to reverse if they did not wish to be deported to Japan
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