1,721,022 research outputs found
Stereoelectroencephalographic (SEEG) study of multifocal epilepsy: A quantitative analysis of epileptic activity during spontaneous night sleep
No full textThe process of consensus building
No full textEvery day a large number of surgical procedures are carried out on an increasingly aging population. There is little evidence on how drugs and techniques used in the perioperative setting can affect mortality. Furthermore, due to the complexity and magnitude of the problem, this evidence is generally not readily available to physicians. Thus, the need for a Consensus Conference about perioperative medicine, debating only high-quality evidence from randomized controlled trials (RCTs), is evident
Neuropsychological and psychometric findings in a large Italian Family with the M239V mutation of the PSEN2 gene
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Long-term administration of butoctamide hydrogen succinate on nocturnal sleep of mentally retarded subjects: a polygraphic study versus placebo
No full textButoctamide hydrogen succinate (BAHS) has been proved to increase REM sleep in patients with reduced REM sleep. Following previous experiments on the effects of BAHS on nocturnal sleep of mentally retarded (MR) subjects, a polygraphic study was conducted on 20 MR subjects (age 8-14 years) to verify the effects of BAHS, 1) after long-term administration and 2) in different etiologies of MR. Subjects were divided into two balanced groups receiving placebo or 400 mg BAHS before sleep for a 6-month period. Basal sleep did not differ substantially in the two groups, both presenting reduced REM sleep. Low amounts of REM sleep were partially reversed by BAHS administration, which caused a significant increase in the REM sleep stage. Post-treatment sleep modifications found in the experimental group were not observed in the control group. BAHS produced its effects on REM sleep immediately after the first administration of the drug, but they became more apparent after long-term treatment. Our findings indicate that long-term administration of BAHS at low dosage maintains its effects on REM sleep of mentally retarded children, causing modifications similar to those previously obtained with single administration at higher dosages in cats, in healthy young and elderly volunteers and in Down's syndrome children. In addition, our observations demonstrate the effectiveness of BAHS on REM sleep, when utilized in mental retardation of etiologies other than Down's syndrome
Effetti della bromocriptina sul sonno notturno dei pazienti parkinsoniani: studio poligrafico
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