1,721,044 research outputs found
Sex differences in ICD benefit
No full textBackground: Implantable cardioverter defibrillators (ICD) have been demonstrated to improve survival, but a considerable number of patients never receive appropriate therapy. The influence of sex on ICD effectiveness in primary prophylactic ICD therapy is unclear. Summary: Until now, guideline recommendations are equal for men and women, yet only an average of 20% of enrolled patients in large randomized ICD studies were women. Epidemiological data from the Framingham Heart Study exhibit lower incidences of SCD in women (approximate to 50%). This difference is in only in part owed to less severe underlying cardiac disease or comorbidities but it persists after correction of confounding factors. Several of the large randomized studies have conducted gender substudies. In MADIT-II, the survival benefit for women was similar as for men, although the risk of appropriate ICD therapy was lower for women. In SCD-HeFT and DEFINITE, the survival benefits for women were less compared to men, or not existent Trends were contradictingly summarized by two meta-analyses. By this important post-hoc research, important hypotheses for prospective work in the ICD subgroup of women are generated. At the same time, it is undisputed that the complication rate of ICD implantations is higher in women. The largest ICD registry to date Ontario (Canada) confirms the lower appropriate shock rate in women but found no differences in total mortality. Conclusions: Further subgroup analyses of large ICD cohorts by sex are needed, as well as studies investigating the influence of sex on ICD treatment and potentially ICD indication prospectively. (C) 2014 Elsevier Inc. All rights reserved.European Community under EU-CERT-ICD [602299
Prevalence of noncardiac findings in computed tomography angiography before transcatheter aortic valve replacement
No full text
Flowerpower: pulsed field ablation of ventricular tachycardia in a patient with Ebstein’s anomaly
No full textOpen-Access-Publikationsfonds 202
First experience with a new tool for automatic mapping of fragmented signals in a case report of cardioneuroablation
No full textCurrent role and future potential of magnetic resonance cholangiopancreatography with an emphasis on incidental findings
No full textPurpose: Aim of this study was to investigate the incidence of relevant biliary and extrabiliary findings in patients undergoing magnetic resonance cholangiopancreatography (MRCP). Materials and Methods: Three hundred eighty-four patients underwent 1.5-Tesla MRCP, and relevant biliary and extra-biliary findings were identified. Results: Four hundred twenty-two biliary findings were identified in 384 patients (75%; 1.1 per patient). Ninety-five patients were free of any relevant biliary finding (25%). Incidental extrabiliaiy findings were observed in 763 patients (1.98/patient). Conclusion: Most of the findings can be diagnosed by MRCP, while others require further examination. Interdisciplinary involvement is recommended to optimize clinical categorization, management, and treatment of these incidental findings. (C) 2014 Elsevier Inc. All rights reserved
Submuscular implantation of insertable cardiac monitors improves the reliability of detection of atrial fibrillation
No full textDiagnosing atrial fibrillation (AF) is highly relevant, as specific secondary prevention is of high importance. Recently, insertable cardiac monitors (ICMs) have been introduced for continuous monitoring to detect asymptomatic episodes of AF. The detection of AF remains challenging due to a relevant incidence of artifacts. This study aimed to compare the effectivity of ICM when placed in a subcutaneous or in a submuscular localization, respectively. We retrospectively analyzed data from 30 patients undergoing pulmonary vein isolation (PVI) for AF and consecutive ICM implantation. ICMs were implanted in two locations: either subcutaneously and parasternally (SC) or under the left major pectoral muscle (SP). Interrogations were continuously retrieved using remote monitoring and during repeated visits in our outpatient clinic. The transmission protocols were scanned for detected AF, and it was ruled by two blinded investigators, if detection was correct or incorrect. Mean age was 67 +/- 10 years, 56 % men, 50 % paroxysmal AF. In 14 of the patients, the ICM was implanted at a SC localization and in 16 patients subpectorally. R-wave amplitude was significantly higher in patents with SP implantation. There were 670 transmitted protocols including 1024 episodes detected as AF. Of these, 54 % were correctly recognized as AF in the SC group. In the SP group, 85 % of the recorded episodes were correctly recognized as AF (p = 0.03). The remaining episodes in both groups showed sinus rhythm with misinterpreted artifacts. To improve effectiveness of detecting AF episodes, it is useful to implant subpectorally
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