923 research outputs found

    Baclofen for the treatment of alcohol use disorder

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    Abstract Baclofen is the only GABA type-B (GABAB) receptor agonist available for use in clinical practice; it has been approved worldwide for the treatment of spasticity for more than 50 years. After the promising results of preclinical studies suggesting a potential role of baclofen in the treatment of alcohol use disorder (AUD), several randomized controlled trials (RCTs) have been conducted to evaluate its safety, tolerability, and efficacy in people with AUD. While the results of these RCTs are contrasting, the off-label use of baclofen in the treatment of AUD has spread, especially in some European countries and in specific settings (e.g., in liver settings). Globally, these efforts have led to the approval of baclofen for AUD in France. Systematic reviews and meta-analyses confirm its efficacy in helping people with AUD to abstain from alcohol, especially those with liver disease or high levels of anxiety. However, the lack of large RCTs limits the conclusions that may be drawn on the potential effecti

    Romain Rolland et L'Heroisme: une Perspective Musicale (Romain Rolland and Heroism: A Musical Perspective)

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    The importance of heroism in the life of Romain Rolland, French author, historian and musicologist has previously been investigated as has been his love of music. The fact that Rolland preferred composers he considered heroic such as Beethoven and Handel led the author of this thesis to believe that there may be a link, as yet unexplored, between Rolland's formulation of heroism and music. The aim of this thesis is to demonstrate that musical influences and the life of certain composers played a central role in the fashioning of Rolland's concept of heroism. The first chapter, Rolland's musical formation covers the formative years of Rolland's life, outlining the development of his musical taste and also his interest in heroism. The influence of his mentor, Malwida von Meysenbug is examined, as is his search for a role model heroic figure. Beethoven, the second chapter, discusses the influence of this composer in Rolland's life and enumerates the musician's heroic qualities which Rolland adapts for the formulation of his own fictional hero. The biography The Life of Beethoven written by the author is also examined. The third chapter, Other heroic musicians investigates Rolland's musicological works in order to highlight heroic qualities found in other composers admired by Rolland. In his most famous work Jean-Christophe, Rolland creates his own heroic figure based on characteristics gleaned from his study of musicians. The character of his protagonist is examined in detail in the fourth chapter, Jean-Christophe. Many composers are criticised by the author for lacking an heroic nature. In order to develop fully the concept of Rolland's hero, a close examination of these 'non-heroic' composers is made in the fifth chapter, The insincerity of musicians. So inspired was Rolland by Beethoven that in writing Jean-Christophe, the author endeavoured to write his own literary 'Heroic Symphony'. The sixth chapter, Rolland's heroic symphony investigates how the author 'musically' structured his novel. The final chapter, Romain Rolland, the hero-prophet discusses how Rolland absorbed many of the heroic qualities that he read about, believing that it was his mission to lead an heroic life and to write inspirational works for his readers

    Romain Rolland: sociologue et ecrivain

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    CHAPTER I:a survey of the life and works of Rolland, based, for the early years of his life, on the biographies of Seippel and Zweig, and for the post-war period, on material compiled from various periodicals. CHAPTER II: an attempt to elaborate Rolland's social philosophy, which is succinctly expressed in the preface to Compagnons de Route: - the concept of dynamic change together with the conflict between spirit and being, individualism and collectivism, and between contemplation and action. Section (i) deals with the study - pursued by Rolland in the spirit of the sociologists of knowledge - of the relation of the intellectual (including the philosophical and artistic) activities of man to the society in which he lives. Under the influence of the First World War and its consequences, the author arrived at the conclusion that knowledge has a class basis. Hence in so far as Rolland espoused the interests of the modern European proletariat, one can profit to examine his philosophy in the light of dialectical materialism. Section (ii) Although, in his ontological thinking, Rolland cast aside the doctrines of materialism and idealism as mere jugglerly of words, nevertheless, deeply impressed since his student days by the monism of Spinoza, he preached the necessity for regarding matter and spirit as an essential unity. He therefore attacked the "faux idéalisme" which tended to dissociate and isolate ideas from their setting in reality; he rejected the theory of "ideas for ideas' sake'’. This philosophy of realism is incorporated in Jean-Christophe and l’ Ame enchantée. In studying social development, Rolland approached the standpoint of historical materialism; he lent importance to the collective action of the masses as an instrument in forging the structure of society. At the same time, he extolled the creative abilities of individual great men who seemed to dominate their age. At first unable to reconcile the two principles of collectivism and individualism, the author finally evolved a new type of humanism in which the interests of the One and the Many were correlated. Section (iii) traces the historical basis for the dialectical philosophy of the author. In the works of Heraclitus, Empedocles, Rousseau and Goethe, Rolland found present the principle of universal movement and change, to which he gave expression in Jean-Christophe and other literary productions. He proceeded to attribute the evolution of the world to the conflict of opposites and thus considered love and hate as two important factors impelling the development of the universe. Section (IV) treats of the epistemological theory of the author. Rolland admired the degree to which the early Greek philosophers verified their knowledge by putting it into use. Consequently he was reluctant to accept a criterion of truth which was based solely on reason or faith, on rationalism or empiricism. He endorsed the logic of Faust: "In the beginning was the deed”, and adjured the intellectuals to test their ideas in the practical activity of the working class. CHAPTER III: the position of the author in the conflict of our age. Early in his career, Rolland had abandonned the nationalist tradition of the French Revolution and had set about to strengthen the cultural bonds between France and Germany. As a result of the first World War, he realized the interdependence not only of the countries of Europe but also of those throughout the world. To this doctrine of internationalism, Rolland joined that of socialism and, in his desire to further the interests of radical elements, was led to moral support of the experiment of the Soviet Union.Arts, Faculty ofFrench, Hispanic, and Italian Studies, Department ofGraduat

    Annales Benjamin Constant, nos 20 et 21, 1997-1998

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    Fink Béatrice. Annales Benjamin Constant, nos 20 et 21, 1997-1998. In: Dix-huitième Siècle, n°31, 1999. Mouvement des sciences et esthétique(s) sous la direction de Christine Rolland, François Azouvi et Michel Baridon. p. 552

    Romain Rolland: Théatre de la Révolution

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    The Clamecy of nineteenth century France was a small, quiet city of Burgundy, no different from countless other French provincial cities. Yet in 1866 it could already boast of two illustrious sons, one, the sixteenth century apostle of liberty, Jean Rouvet, the other and better known, the pamphleteer and novelist of the early nineteenth century, author of Mon oncle Ben- jamin, Claude Tillier.But its most signal honor had yet to come. It was at Clamecy on January 29, 1866, that Romain Rolland was born, the son of maître Rolland, the respectable and well-to-do lawyer of the town. By the end of the century, Romain Rolland had embarked on a career which was to bring him into the limelight not only of the literary scene but of the political and international field as well

    Patrice Thompson : Les Écrits de Benjamin Constant sur la religion. Essai de liste chronologique. Préface et révision de Pierre Deguise avec la collaboration de Boris Anelli, (Coll. «Travaux et recherches de l'Institut Benjamin Constant ») 1998

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    Fink Béatrice. Patrice Thompson : Les Écrits de Benjamin Constant sur la religion. Essai de liste chronologique. Préface et révision de Pierre Deguise avec la collaboration de Boris Anelli, (Coll. «Travaux et recherches de l'Institut Benjamin Constant ») 1998. In: Dix-huitième Siècle, n°31, 1999. Mouvement des sciences et esthétique(s) sous la direction de Christine Rolland, François Azouvi et Michel Baridon. p. 650

    Correspondence Romain Rolland - Gaston Thiesson (1915-1919)

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    Romain Rolland et Gaston Thiesson se rencontrent en août 1912 en Suisse mais leur amitié se renforce lors des deux séjours du peintre dans ce pays durant la première Guerre mondiale, entre septembre 1915 et avril 1916. Sur les 166 lettres présentées ici, 86 lettres sont échangées durant cette période. La venue de Thiesson, au moment où Rolland décide de se retirer de la mêlée, est un réconfort pour l’écrivain attaqué par la presse nationaliste qui l’accuse de défaitisme à la suite de ses articles parus au Journal de Genève. Rolland voit en lui un homme courageux et dévoué qui, après la parution du libelle de Henri Massis Romain Rolland contre la France, veut recueillir avec l’aide des journalistes Jacques Mesnil et Georges Pioch des témoignages de soutien à paraître dans Les Hommes du Jour. L’engagement du peintre pour la défense des idées pacifistes de l’auteur de Au-dessus de la mêlée, est semée d’embûches (les réactions de P.-H. Loyson notamment) et la parution des témoignages est un succès en demi-teinte. Touché par cet homme au cœur tendre, dont les mésaventures le remplissent de compassion, Rolland exprime dans ses lettres sa foi dans les forces de l’art et de la bonté. Après son installation au bord du lac Léman, Thiesson séjourne à Montana avec le poète Pierre Jean Jouve. Après un voyage à travers la Suisse, il rentre en France où il meurt trois ans plus tard. Cette correspondance révèle la volonté exigeante de Romain Rolland de mettre en accord une pensée, une vie et un art pour mieux les opposer tous ensemble aux forces destructrices de la haine, dans la recherche héroïque et périlleuse d’une entente entre les êtres et d’une harmonie entre les peuples.Romain Rolland and Gaston Thiesson first met in August 1912 in Switzerland but their friendship got stronger when the painter happened to spend some time in that country, during World War I, twice between September 1915 and April 1916. Among the 166 letters presented here, 86 were exchanged during that period. Thiesson’s coming to support him, at the very time when Rolland decided to retire, was very comforting for the writer who was being attacked by the nationalist press that accused him of defeatism after he had published some leading articles in the Journal de Genève. Rolland saw him as a brave and devoted man who, after Henri Massis published his pamphlet Romain Rolland contre la France, wanted to gather, with the journalists Jacques Mesnil et Georges Pioch’s help, expressions of support to be published in Les Hommes du Jour. The painter’s commitment in favour of the author of Au-dessus de la mêlée, is full of ups and downs (P.-H. Loyson’s reactions particularly) and the publishing of the testimonies a half tone success. Moved by this soft-hearted man, whose misadventures fill him with compassion, Rolland expressed, in his letters, his faith in the strength of Art and kindness. After settling near the Lac Leman, Thiesson stayed in Montana for a while with poet Pierre Jean Jouve. After travelling around Switzerland, he went back to France, and died there three years later. This correspondence gives away Romain Rollands’s demanding will that a way of thinking has to match a way of living and a way of seeing Art but then he wants to oppose them all to the destroying forces of hatred, in the heroic and perilous search of meeting of minds between people and harmony between peoples

    Correspondance Romain Rolland - Gaston Thiesson (1915-1919)

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    Romain Rolland et Gaston Thiesson se rencontrent en août 1912 en Suisse mais leur amitié se renforce lors des deux séjours du peintre dans ce pays durant la première Guerre mondiale, entre septembre 1915 et avril 1916. Sur les 166 lettres présentées ici, 86 lettres sont échangées durant cette période. La venue de Thiesson, au moment où Rolland décide de se retirer de la mêlée, est un réconfort pour l écrivain attaqué par la presse nationaliste qui l accuse de défaitisme à la suite de ses articles parus au Journal de Genève. Rolland voit en lui un homme courageux et dévoué qui, après la parution du libelle de Henri Massis Romain Rolland contre la France, veut recueillir avec l aide des journalistes Jacques Mesnil et Georges Pioch des témoignages de soutien à paraître dans Les Hommes du Jour. L engagement du peintre pour la défense des idées pacifistes de l auteur de Au-dessus de la mêlée, est semée d embûches (les réactions de P.-H. Loyson notamment) et la parution des témoignages est un succès en demi-teinte. Touché par cet homme au cœur tendre, dont les mésaventures le remplissent de compassion, Rolland exprime dans ses lettres sa foi dans les forces de l art et de la bonté. Après son installation au bord du lac Léman, Thiesson séjourne à Montana avec le poète Pierre Jean Jouve. Après un voyage à travers la Suisse, il rentre en France où il meurt trois ans plus tard. Cette correspondance révèle la volonté exigeante de Romain Rolland de mettre en accord une pensée, une vie et un art pour mieux les opposer tous ensemble aux forces destructrices de la haine, dans la recherche héroïque et périlleuse d une entente entre les êtres et d une harmonie entre les peuples.Romain Rolland and Gaston Thiesson first met in August 1912 in Switzerland but their friendship got stronger when the painter happened to spend some time in that country, during World War I, twice between September 1915 and April 1916. Among the 166 letters presented here, 86 were exchanged during that period. Thiesson s coming to support him, at the very time when Rolland decided to retire, was very comforting for the writer who was being attacked by the nationalist press that accused him of defeatism after he had published some leading articles in the Journal de Genève. Rolland saw him as a brave and devoted man who, after Henri Massis published his pamphlet Romain Rolland contre la France, wanted to gather, with the journalists Jacques Mesnil et Georges Pioch s help, expressions of support to be published in Les Hommes du Jour. The painter s commitment in favour of the author of Au-dessus de la mêlée, is full of ups and downs (P.-H. Loyson s reactions particularly) and the publishing of the testimonies a half tone success. Moved by this soft-hearted man, whose misadventures fill him with compassion, Rolland expressed, in his letters, his faith in the strength of Art and kindness. After settling near the Lac Leman, Thiesson stayed in Montana for a while with poet Pierre Jean Jouve. After travelling around Switzerland, he went back to France, and died there three years later. This correspondence gives away Romain Rollands s demanding will that a way of thinking has to match a way of living and a way of seeing Art but then he wants to oppose them all to the destroying forces of hatred, in the heroic and perilous search of meeting of minds between people and harmony between peoples.MONTPELLIER-BU Lettres (341722103) / SudocSudocFranceF

    The thrie tailes of the thrie priests of Peblis [electronic resource] : Contayning manie notabill examples and sentences, and (that the paper should not be voide) supply it with sundrie merie tailes, verie pleasant to the reider, and mair exactlie corrected than the former impression.

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    Signatures: A-Ep4s[-E4].Attributed to John Rolland in Lowndes' Bibliographer's manual and the British Museum Catalogue.Printer's device (McKerrow 307) on title page.At bottom of title page: Cum privilegio regali."The text of "Thrie priests of Peblis" is printed on the inner two-thirds of each leaf; parallel to it, printed on the outer one-third of each leaf, is a text entitled "Mery tailes". This consists of 47 of "A C. mery tayles", moral tag lines omitted, selected from an undated edition described in Shakespeare jest-bookes, ed. by W. Carew Hazlitt, v. 1 (1864)."--DFo.Leaves B1, E2 and E3 lacking; replaced with handwritten leaves.Print faded; pages stained and torn.Reproduction of original in the Bodleian Library.STC (2nd ed.)Electronic reproduction
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