651 research outputs found
World War I record of service survey for Benjamin W. Gleason, signed 20 February 1926.
No full textQuestionnaire about Benjamin Whitney Gleason's service in World War I, 1917-1919, signed by Gleason on 20 February 1926.Questionnaire originally part of a survey of Norwich University alumni conducted by a “Norwich in the World War” committee consisting of Charles N. Barber (chairman), Carl V. Woodbury, K.R.B. Flint, and Gustaf A. Nelson. Data from these questionnaires may have been used in a chapter of "Vermont in the world war, 1917-1919" by Harold P. Sheldon (1928)
Adolescents Becoming Feminist on Twitter: New Literacies Practices, Commitments, and Identity Work
No full textThe author investigated the relation between young people's new literacies practices and identity development on Twitter and found that participants used three new literacies practices (live‐tweeting, hashtagging, and information sharing) in unique ways to develop feminist identities in this social media space. Participants mobilized popular culture to initiate dialogue about feminist issues, such as the wage gap, to participate in social activism (e.g., advocating for women's reproductive care), and to provide informal counsel to peers. Twitter can be a vital space for young people to become feminists, providing opportunities to learn, develop, and participate.This accepted article is published as Gleason, B. (2018). Adolescents becoming feminist on Twitter: New literacies practices, commitments, and identity work. Journal of Adolescent & Adult Literacy. 62(3); 281-289. DOI: 10.1002/jaal.889. Posted with permission. </p
The gleason distance РАССТОЯНИЕ ГЛИСОНА
No full textFirst, some basic concepts are considered in the paper, including the Mobius transformation, the unit ball in the space of related analytical functions in the unit circle, and the Gleason distance. The author proves a theorem (demonstrated without any proof) that makes it possible to calculate the Gleason distance between the two opposite points in the pre-set unit circle. The extremum feature appears in the calculation of the Gleason distance, which coincides with the identity map of the unit circle. The Gleason distance between the two points coincides with the regular Euclidean distance between these points. Further, the author considers the Gleason distance in the simply connected domain. The simply connected domain is conformally represented in the unit circle. The two points in the simply connected domain are represented as the corresponding points in the unit circle. The author has proven that the Gleason distance between the two points in the simply connected domain coincide with the Gleason distance between two corresponding points in the unit circle. Then, the author presents a lemma (a statement without proof). It is applied to the problem of the Gleason distance between the two points in the simply connected domain. Next, the author presents several special cases: the Gleason distance as calculated between the two points in the unit circle and between the two points in the upper half-space. The two points are located (with both points being positive numbers) in the unit circle.Приведена теорема для вычисления расстояния Глисона между двумя противоположными точками, лежащими в единичном круге, а также лемма о получении экстремальной функции в этой задаче. Разобраны частные случаи вычисления расстояния Глисона в единичном круге и в верхней полуплоскости
[Bill Gleason, St. Louis Browns, baseball card portrait]
No full textBaseball card title devised by Library staff.Issued by: D. Buchner & Company."Will Gleason"- - caption on card.Restricted access: Materials in this collection are extremely fragile and cannot be served.Forms part of: Baseball cards from the Benjamin K. Edwards Collection
Daily Reflections (Meditations) on the Scriptures from the Roman Catholic Lectionary.
No full textIn today's Gospel reading we see that Jesus' words are not enough to convince the skeptics that He is Christ. Jesus proclaims:|The works I do in my Father's name testify to me.|But you do not believe, because you are not among my sheep.|My sheep hear my voice|I am immediately drawn to the imagery of active listening. The Gospel reading illustrates how the skeptics are not listening carefully to Jesus' words, nor are they attentive to His works. Kay Lindahl, author of Listening: A Sacred Art and a Spiritual Practice, states: "to become a listening presence we need to prepare – not only to listen to others, but also to listen to ourselves and to listen to God." Let us believe in His works and embody Him as we journey through life.|Let us take time to recognize Jesus for all of his glory, and to listen carefully so that we may follow in his footsteps. "Listening is more than hearing words, and more than an act; it's an art. What do we mean by the word art? At-oneness. Those times when we are fully present with whatever we are doing are times of oneness. Some people call them holy moments." (Kay Lindahl) I encourage us all to be "at-oneness" with ourselves, with our neighbors, and most importantly with God.|As we begin our day, let us take a moment to reflect on today's readings. Let God grant us patience to listen intently and to understand his presence in our lives more fully. Let us not waiver in our faith, and let us express our faith lovingly to our brothers and sisters.|Ame
Ukrainian Higher Education in Transition: Perspective and Policy Implications
No full textThis article is written by William Gleason, is Chair of Advanced Polish & Ukrainian Area Studies and Coordinator of Eurasian Area Studies at the Foreign Service Institute of the U.S. Department of State. Dr. Gleason is a long time Russia and Eastern Europe expert who oversees a key training program for American diplomats preparing to serve in the region. Dr. Gleason served as Public Policy Scholar at the Woodrow Wilson International Center and as director of the Fulbright Program for Ukraine in 1998 – 2000. He lectured at numerous universities including the National University of Kyiv-Mohyla Academy. He is the author of numerous books and publications on history, culture and interactions on Russia and Ukraine
An oration, pronounced before the Republican citizens, of the town of Hingham, in commemoration of American independence. July 4th, 1807. By Benjamin Gleason, A. M. ...
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Learning with social media: Bringing popular platforms into the classroom to develop literacy, identity, and citizenship
No full textWalk into almost any secondary school today and you’ll see students seemingly glued to their phones. A study from 2018 revealed that almost 50% of youth are online “almost constantly” and they’re often engaging with social media, whether watching videos on YouTube, participating in the latest dance craze on TikTok, checking Facebook, or making videos on Snapchat. Through these sites, young people are creating sophisticated digital stories, finding and sharing relevant information, contributing to current discussions and, in short, developing digital literacy, digital citizenship, language, and other valuable 21st-century skills.This article is published as Gleason, B., Learning with social media: Bringing popular platforms into the classroom to develop literacy, identity, and citizenship. Literacy Today, Nov/Dec 2019; 26-28. Posted with permission.</p
The best of all worlds: Combining the flipped classroom, game-based learning, and learning communities in a large technology integration course.
No full textThis paper presents the use of a combination of pedagogical strategies in teaching a large undergraduate technology integration course. Course revisions include a motivating game-based learning structure, practitioner-focused design, and the flipped classroom model. Students perceived each course change positively with suggestions for refinement.This conference paper is published as Nadolny, L. and Gleason, B. (2018). The best of both worlds: Combining the flipped classroom, gamebased learning, and smaller breakout sessions in a large technology integration course. Paper presented at Annual Conference of Society for Information Technology and Teacher Education, Washington, D.C., March 26-30.Posted with permission.</p
Design, synthesis and evaluation of selective estrogen receptor modulator/histone deacetylase inhibitor merged bifunctional ligands
No full textBreast cancer remains one of the most persistent threats to women's health in the Western world. The selective estrogen receptor modulator (SERM) tamoxifen is a front-line treatment for the disease, but suffers from a high rate of acquired resistance and an increased risk of endometrial cancer. As such, improved small molecule inhibitors with the ability to overcome antiestrogen resistance while limiting adverse side effects are valuable pharmaceutical targets. Histone deacetylase inhibitors (HDACi) have recently emerged as versatile anticancer agents with antiproliferative activity in breast cancer cells. Combination therapy of SERMs and HDACi has demonstrated enhanced cytotoxicity and the ability to restore tamoxifen sensitivity to antiestrogen-resistant cancer cell lines. This research project describes a novel approach to overcoming antiestrogen resistance by combining the anticancer properties and cooperative activity of SERMs and HDACi into compact, merged bifunctional ligands. Previous research by the Gleason laboratory indicated that HDACi functionality, in the form of zinc-chelating hydroxamic acids, could be integrated into the polar side chain of SERMs while maintaining antiestrogenicity at micromolar concentrations. Building from these preliminary results, a series of novel hybrid molecules was designed with zinc-binding groups incorporated into the aliphatic side chain or the triphenylethylene core structure of the active tamoxifen metabolite 4-hydroxytamoxifen (4-OHT). The resulting structures were investigated in silico using the molecular docking program FITTED. Twelve hybrid compounds were then synthesized by geminal Suzuki coupling and McMurry coupling procedures. Despite the propensity of the compounds to isomerize around the central double bond, the majority of the syntheses proceeded diastereoselectively and HPLC purification furnished the final products as a single isomer or in good diastereomeric excess. The HDAC inhibition and ER antagonism of the bifunctional molecules were evaluated in collaboration with the Mader laboratory of the Université de Montréal. Side chain-substituted hybrid compounds demonstrated good affinity for the ER binding pocket and nanomolar ER inhibitory activity. In addition, long-chain chimeric ligands possessing amide linkers exhibited significant HDAC 6 inhibition, with one compound displaying inhibitory activity at sub-micromolar concentrations. However, these side-chain substituted hybrids also exhibited substantial ER agonism in the absence of estradiol, which limited their effectiveness as antiestrogens. Conversely, a compound containing a phenyl hydroxamic acid in the aromatic core of 4-OHT acted as a full antagonist at micromolar concentrations and displayed no estrogenic behaviour. The core-substituted hybrid also exhibited modest HDAC inhibition, though it lacked the strong activity of its side chain counterparts. The synthesized SERM/HDACi molecules therefore displayed encouraging results and provided important structural insight into the future creation of bifunctional ligands.A brief side project is also described as a contribution towards the total synthesis of (R)-puraquinonic acid. The enantioselective synthesis of this natural product was previously accomplished by the Gleason group using a novel lactam auxiliary alkylation sequence to set the molecule's sole stereocenter. However, the specific rotation of the final product was opposite that expected and contradicted previous stereochemical assignments of the alkylation sequence. To address this inconsistency, a convergent stereochemical proof was completed which allowed direct comparison of alkylation products to auxiliary-based Mannich addition products that could be characterized by X-ray diffraction. The absolute stereochemistry of the sequence was thereby unambiguously assigned and strongly supported the conclusion that our group had successfully synthesized (R)-puraquinonic acid.Le modulateur sélectif des récepteurs des œstrogènes (SERM) tamoxifène est le traitement principal pour le cancer du sein, mais souffre d'un taux élevé de résistance acquise et augmente le risque de developer un cancer de l'endomètre. Par conséquence, de nouvelles molécules antiestrogénique avec la capacité de surmonter la résistance aux antioestrogènes et de limiter les effets secondaires indésirables sont nécessaires. Les inhibiteurs d'histones déacétylase (HDACi) ont récemment emergés comme des agents possédant une activité antiproliférative contre les cellules du sein cancéreuse. La thérapie combinatoire des SERMs et HDACi démontre non seulement une cytotoxicité améliorée, mais aussi la capacité de restaurer la sensibilité envers tamoxifène dans les lignées cellulaires de cancer résistantes aux antioestrogènes. Ce projet décrit une nouvelle stratégie pour combattre la résistance antioestrogène en combinant l'activité des SERMs et des HDACi par la fusion des pharmacophores pour produire des ligands bifonctionnels.Les recherches précédentes par le laboratoire du Dr. Gleason ont indiqué que la fonctionnalité HDACi - sous la forme d'acides hydroxamiques - peut être intégrée dans la chaîne polaire des SERMs tout en conservant une antiestrogenicité modérée. Basé sur ces résultats préliminaires, une série de nouvelles molécules hybrides a été conçue avec des groupes se liant au zinc incorporés soit dans la chaîne latérale ou dans la structure centrale triphényléthylène du métabolite actif de tamoxifène, 4-hydroxytamoxifène (4 -OHT). Ces molécules ont été étudiés in silico à l'aide de FITTED, un programme de modélisation moléculaire. Douze molécules hybrides ont été synthétisées par des reactions de Suzuki et des réactions de McMurry. La majorité des synthèses ont pu être accomplies d'une manière diastéréosélective et la purification par CLHP a fourni les produits finaux sous forme d'isomère pure ou dans de bons excès diastéréoisomèriques.Les molecules bifonctionnelles ont été évaluées pour l'inhibition des HDACs et l'antagonisme envers le recepteur d'oestrogens (ER) en collaboration avec le laboratoire du Dr. Mader à l'Université de Montréal. Les hybrides possédant une acide hydroxamique sur la chaîne laterale ont démontré une bonne affinité pour ER de l'ordre nanomolaire. De plus, les ligands chimériques à longue chaîne possédant un amide ont démontré une inhibition importante envers HDAC 6 à une concentration micromolaire. Cependant, ces hybrides ont également démontré une activité agoniste substantielle de ER, qui limité leur efficacité comme antioestrogènes. Par contre, un hybride contenant un acide hydroxamique dans la structure centrale aromatique de 4-OHT a agi comme une antagoniste à des concentrations micromolaires, sans comportement oestrogénique. Les molécules ciblant SERM/HDACi offrent donc des résultats initiaux encourageants et des leçons importantes pour la création de nouveaux ligands bifonctionnels.Un bref projet contribuant à la synthèse totale de l'acide (R)-puraquinonique est aussi décrit. La synthèse énantiosélective de ce produit naturel a été accompli par le groupe Gleason avec l'aide d'une séquence d'alkylation utilisant un auxiliaire chirale bicyclique pour établir l'unique stéréocentre de la molécule. Toutefois, le pouvoir rotatoire spécifique du produit final était l'inverse de ce qui était attendu, et en contradiction avec la stéréochimie précédente de la séquence d'alkylation. Pour prouver la stéréochimie de notre processus d'alkylation, une voie de synthèse convergente a été accomplie qui a permis une comparaison directe des produits d'alkylation avec des produits d'addition de Mannich dont on était capable de caractériser par diffraction aux rayons X. La stéréochimie absolue de la séquence a été ainsi assignée sans ambiguïté et procure une confirmation que notre groupe avait réussi à synthétiser l'acide (R)-puraquinonique
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