92 research outputs found
Graph models of network behavior in environmental planning
No full textPolicies to protect the environment in Europe and in the rest of the world have been adjusted to take into account the network behavior of conglomerates of nature protection areas. Network behavior can emerge from the natural configuration of habitat patches, or be induced by the establishment of habitat corridors. Careful planning is required to protect and improve the network behavior in existing sites; this has prompted researchers to build graph models of ecological networks, and apply complex network analysis to improve the understanding of their features. However, the most common approach is to keep the focus on a single species, meant to be representative of most species within the area under analysis, or especially important with respect to conservation issues. In this paper, data pertaining to land use types found within sites making up the "Natura 2000" ecological network is used to provide a high-level view of the network, and propose a framework for study, in which similarity measures are used as a criterion to suggest guidelines for land management
A design pattern for multimodal and multidevice user interfaces
No full textIn this paper, we introduce the MVIC pattern for creating multidevice and multimodal interfaces. We discuss the advantages provided by introducing a new component to the MVC pattern for those interfaces which must adapt to different devices and modalities. The proposed solution is based on an input model defining equivalent and complementary sequence of inputs for the same interaction. In addition, we discuss Djestit, a javascript library which allows creating multidevice and multimodal input models for web applications, applying the aforementioned pattern. The library supports the integration of multiple devices (Kinect 2, Leap Motion, touchscreens) and different modalities (gestural, vocal and touch). Copyright is held by the owner/author(s)
Correction to: Long-term treatment of hereditary transthyretin amyloidosis with patisiran: multicentre, real-world experience in Italy(Neurological Sciences, (2024), 10.1007/s10072-024-07494-9)
No full textThe article “Long‐term treatment of hereditary transthyretin amyloidosis with patisiran: multicentre, real‐world experience in Italy”, written by Luca Gentile, Anna Mazzeo, Chiara Briani, Silvia Casagrande, Marcella De Luca1, Gian Maria Fabrizi, Christian Gagliardi, Chiara Gemelli, Francesca Forcina, Marina Grandis, Valeria Guglielmino, Giacomo Iabichella, Luca Leonardi, Alessandro Lozza, Fiore Manganelli, Roberta Mussinelli, Filomena My, Giuseppe Occhipinti, Silvia Fenu, Massimo Russo, Angela Romano, Alessandro Salvalaggio, Matteo Tagliapietra, Stefano Tozza, Giovanni Palladini, Laura Obici and Marco Luigetti, was originally published electronically on the publisher’s internet portal on 16 April 2024 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 27 July 2024 to © The Author(s) 2024 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0. The original article has been corrected
Socialist competition as an element of employee motivation in the era of «stagnation» (on the example of enterprises in Chelyabinsk)
No full textПетров Евгений Алексеевич, магистр, Южно-Уральский государственный университет (Челябинск,
Российская Федерация). E-mail: [email protected]. E. A. Petrov, [email protected]
South Ural State University, Chelyabinsk, Russian FederationВ статье на примере Челябинского тракторного завода и Челябинского электролитного
цинкового завода рассматривается влияние социалистического соревнования на мотивацию
труда работников. Автор приходит к выводу, о том, что стимулы, представлявшиеся участникам
соревнования, были недостаточны, а отношение к нему было формальным на всех уровнях. The article examines the influence of socialist competition on the motivation of workers using the
example of the Chelyabinsk Tractor Plant and the Chelyabinsk Electrolytic-Zinc Plant. The author
concludes that the incentives presented to the participants in the competition were insufficient, and
the attitude towards him was formal at all levels.Исследование выполнено при финансовой поддержке государственного задания Минобрнауки Российской Федерации, проект № FENU-2020-0021 «Изучение региона в контексте глобально-исторических связей с помощью методов цифровой гуманитаристики (на примере Челябинска и Челябинской области)». The research was carried out with the financial support of the state task of the Ministry of education and science
of the Russian Federation, project No FENU-2020-0021 «Studying the region in the context of global-historical
relations using digital Humanities methods (on the example of Chelyabinsk and the Chelyabinsk region)»
La donna che cammina. Incanto e mito della seduzione del passo femminile nella poesia italiana del primo Novecento
No full textThe role of cell-matrix interactions in connective tissue mechanics
No full textLiving tissue is able to withstand large stresses in everyday life, yet it also actively adapts to dynamic loads. This remarkable mechanical behaviour emerges from the interplay between living cells and their non-living extracellular environment. Here we review recent insights into the biophysical mechanisms involved in the reciprocal interplay between cells and the extracellular matrix and how this interplay determines tissue mechanics, with a focus on connective tissues. We first describe the roles of the main macromolecular components of the extracellular matrix in regards to tissue mechanics. We then proceed to highlight the main routes via which cells sense and respond to their biochemical and mechanical extracellular environment. Next we introduce the three main routes via which cells can modify their extracellular environment: exertion of contractile forces, secretion and deposition of matrix components, and matrix degradation. Finally we discuss how recent insights in the mechanobiology of cell-matrix interactions are furthering our understanding of the pathophysiology of connective tissue diseases and cancer, and facilitating the design of novel strategies for tissue engineering.BN/Gijsje Koenderink LabBiomaterials & Tissue Biomechanic
Model-free tuning of plants with parasitic dynamics
No full textWe have recently considered the problem of tuning a static plant described by a differentiable input-output function, which is completely unknown, but whose Jacobian takes values in a known polytope of matrices: To drive the output to a given desired value, we have suggested an integral feedback scheme, whose convergence is ensured if the polytope of matrices is robustly full row rank. The suggested tuning scheme may fail in the presence of parasitic dynamics, which may destabilize the loop if the tuning action is too aggressive. Here we show that such tuning action can be applied to dynamic plants as well if it is sufficiently 'slow', a property that we can ensure by limiting the integral action. We provide robust bounds based on the exclusive knowledge of the largest time constant and of the matrix polytope to which the system Jacobian is known to belong. We also provide similar bounds in the presence of parasitic dynamics affecting the actuators.Team Tamas Keviczk
JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
No full textThe Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress. Dysregulation in this pathway can lead to severe immunodeficiencies and malignancies, and its role extends to neurotransduction and pro-inflammatory signaling mechanisms. Although JAK inhibitors (Jakinibs) have successfully treated immunological and inflammatory disorders, their application has generally been limited to diseases with similar pathogenic features. Despite the modest expression of JAK-STAT in the CNS, it is crucial for functions in the cortex, hippocampus, and cerebellum, making it relevant in conditions like Parkinson's disease and other neuroinflammatory disorders. Furthermore, the influence of the pathway on serotonin receptors and phospholipase C has implications for stress and mood disorders. This review expands the understanding of JAK-STAT, moving beyond traditional immunological contexts to explore its role in stress-related disorders and CNS function. Recent findings, such as the effectiveness of Jakinibs in chronic conditions such as rheumatoid arthritis, expand their therapeutic applicability. Advances in isoform-specific inhibitors, including filgotinib and upadacitinib, promise greater specificity with fewer off-target effects. Combination therapies, involving Jakinibs and monoclonal antibodies, aiming to enhance therapeutic specificity and efficacy also give great hope. Overall, this review bridges the gap between basic science and clinical application, elucidating the complex influence of the JAK-STAT pathway on human health and guiding future interventions. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s).122020900136–4, FENU-2023–0014This work was funded by South Ural State University, scientific theme No. FENU-2023–0014 and partly by the theme 122020900136–4 of Institute of Immunology and Physiology
INTERNATIONAL COMPONENT IN THE DEVELOPMENT OF UNIVERSITY CHINESE STUDIES IN THE 1990S: ON THE EXAMPLE OF FENU
No full textСтатья посвящена роле российско-китайского сотрудничества в развитии китаеведения Дальневосточного государственного университета в 1990-е годы. На основе использования разнообразных исторических источников автор анализирует факты международных контактов в Дальневосточном университете, как состав китайских делегаций, прибывавших в ДВГУ, стажировки студентов-китаистов ДВГУ в КНР и т.д.The article is devoted to the role of Russian-Chinese cooperation in the development of Sinology at the Far Eastern State University in the 1990s. Based on the use of various historical sources, the author analyzes the facts of international contacts at the Far Eastern University, such as the composition of the Chinese delegations arriving at the Far Eastern State University, internships for Chinese students of the Far Eastern State University in the PRC, etc.262-26
Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces
No full textLiving organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D-printed voxels from either hard or soft phase to decode this relationship. Combining micro/macroscale experiments and finite element simulations, a power law model emerges, linking voxel arrangement to composite properties. This model guides the creation of voxel-level FG structures, resulting in two biomimetic constructs mimicking specific bone-soft tissue interfaces with superior mechanical properties. Additionally, the model studies the FG influence on murine preosteoblast and human bone marrow-derived mesenchymal stromal cell (hBMSC) morphology and protein expression, driving rational design of soft-hard interfaces in biomedical applications.Biomaterials & Tissue BiomechanicsBN/Gijsje Koenderink LabMechatronic Desig
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