36,807 research outputs found
Michael Rodriguez interviews fiction writer Michael Kimball
No full textAuthor Michael Kimball talks about moving away from Michigan to become a successful writer, his education, the fiction reading series he has started in Baltimore, the life-story-on-postcard project, and his book "Dear everybody." Kimball is interviewed by Michigan State University Librarian Michael Rodriguez for the Michigan State University Libraries' Michigan Writers Series
Detection and diagnosis of acute viral encephalitis
Full text linkIntroduction
Acute viral encephalitis is a severe form of brain inflammation due to sporadic infection, typically with herpes simplex virus, or epidemic/pandemic infections. Epidemiological data are particularly important for pandemic viruses. Although new reporting approaches are often considered, no real-time clinical data collection tool has been developed. These data are dependent on diagnosis of individual cases. However, the aspects of management that result in delays and missed diagnoses are not clear and it is not known if interventions can improve sample collection and diagnosis. Whilst the importance of cytokines and associated mediators is increasingly recognised, signatures associated with specific aetiologies have not been established. Also, it is not known whether these mediators correlate with clinical severity and outcome, or their impact on blood-brain barrier permeability.
Methods
I undertook a national surveillance study through neurology networks, and investigated alternative notification approaches. I undertook a multicentre cross-sectional study of clinical investigation, studied viral load and assessed the impact of a lumbar puncture pack. I used bead array to assess mediator profiles and assessed the albumin ratio and viral load, in samples from a Health Protection Agency study. I examined profiles with respect to aetiology, disease severity and outcome and compared this with histopathology tissue and a blood-brain barrier model.
Results
In the context of a pandemic influenza virus, existing mechanisms identified limited cases, and a smartphone application was developed to collect real-time data. Delays in lumbar puncture and sub-optimal sample collection were identified, in association with a lower viral load. A lumbar puncture pack improved sample collection. Mediator profiles differed between those with an infectious versus immune-mediated aetiology, and those of unknown aetiology best reflected infectious; particularly myeloperoxidase, in part relating to neutrophils in cerebrospinal fluid and parenchyma. The interleukin1 antagonists, IL1RA and IL10, were associated with coma and outcome; and IL10 with reduced blood-brain barrier permeability. Adhesion molecules may counteract this, in both clinical samples and the model.
Conclusions
Current limitations of detection may be augmented with novel real-time technologies. Diagnosis is limited by delayed and sub-optimal sample collection, which can be improved with a simple pack. Mediators profiles may assist in the distinction of infectious from immune-mediated encephalitis, and cytokines that act against IL1 correlated with clinical severity and outcome. This may be more closely associated with outcome than viral load, although this may reflect sample timing. These findings should direct future research to develop approaches for improved diagnostics and adjunctive therapies
Michael Rodriguez interviews author Paul Clemens
No full textAuthor Paul Clemens talks about his book "Made in Detroit," the genre of memoir, and writing about race. Clemens is interviewed by Michigan State University Librarian Michael Rodriguez for the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
An Anthropologist at Work: Ruth Benedict's Poetry
Full text linkRuth Benedict, an influential twentieth-century anthropologist best known for her Patterns of Culture (1934), has written a considerable range of poems, a good number of which have been published in distinguished poetry journals such as Monroe's Poetry. Considering her double interest in poetry and anthropology and her use of modernist poetic techniques, this writer's works are privileged sites for an interrogation of the complex relations between cultural alterity (ethnic otherness) and poetic alterity (poeticity, literariness). Benedict emerges as a modernist poet of a different sort. Her rhymes and religious subject matter testify to her rootedness in nineteenth-century aesthetics, but her complex interweaving of cultural and poetic forms of alterity place her at the heart of a modernist enterprise, whose frantic search for new forms of artistic expression has from its beginnings been bound up with a sustained interest in the language and practices of cultural others
Michael Rodriguez interviews author Tom Springer
No full textAuthor Tom Springer is interviewed about his writing career and his newest book "Looking for hickories". Springer talks about his career following after earning an Environmental Journalism degree from Michigan State University. He calls his genre "creative non-fiction" and explains how he weaves his memories into his books about life in rural and wild Michigan. Part of the Michigan State University Libraries' Michigan Writers Series. Springer is interviewed by Librarian Michael Rodriguez
Michael Rodriguez interviews author Gary Gildner
No full textAuthor Gary Gildner explains why he left his tenured teaching position to move to Idaho to became a full-time writer of poetry. Gildner talks about donating his personal papers to Michigan State University Libraries' Special Collections, his writing style and how he approaches writing. Gildner is interviewed by MSU Librarian Michael Rodriguez for the MSU Libraries' Michigan Writer Series. Held at the MSU Main Library
Michael Keaton, Keira Knightley, Benedict Cumberbatch, and Mark Ruffalo at the 2014 (87th) Governors Awards presentation
No full textFrom left: Michael Keaton, Keira Knightley, Benedict Cumberbatch, and Mark Ruffalo at the 2014 (87th) Governors Awards presentation. Color tiff
Gold standard of UK degrees is lost in translation
No full textInflated marks, overworked staff and politically compromised courses are the price of exploiting offshore UK registered students, says Michael Day
Michael Rodriguez interviews historian and author Keith Widder
No full textHistorian and author Keith Widder talks about his move to Michigan from Wisconsin, his career as Curator of History for the Mackinac Island State Park Commission, his research interests, his book "Michigan Agricultural College", and his current projects. Widder is interviewed by Michigan State University Librarian Michael Rodriguez for the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
Benedict Anderson (1936-2015)
No full textFil: Goebel, Michael. Freie Universität Berlin; Alemania.El 13 de diciembre del año pasado falleció en Java Oriental Benedict Anderson, uno de los historiadores más conocidos e influyentes del último medio siglo. Mundialmente su fama se debió principalmente a un gran pequeño libro publicado en 1983: Comunidades imaginadas, que refundó los términos de debate sobre nacionalismos y estados-nación, creando casi un nuevo campo de estudio. En América Latina, en cambio, la reputación del libro en parte se basó en su argumento de que el nacionalismo se había originado no en Europa, sino en la América española, validando de este modo el interés por la historia latinoamericana como pocos otros libros
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