635 research outputs found
Membro Collegio Docenti Dottorato di Architettura degli Interni membro e Allestimento (coordinatore prof. M. Petreschi), presso il Dipartimento di Architettura e Costruzione (ArCos), Facoltà di Architettura Valle Giulia- Università degli Studi di Roma “La Sapienza”
No full textmembro del Collegio dei Docenti del Dottorato di ricerca in Architettura degli interni e Allestimento – dal XX ciclo (coordinatore prof. M. Petreschi), presso il Dipartimento di Architettura e Costruzione (ArCos), Facoltà di Architettura Valle Giulia- Università degli Studi di Roma “La Sapienza”, nell’ambito del qualeha svolto lezioni nei cicli di dottorato dal 2004 al 2008
The Development of Soil Science in Friuli Venezia Giulia
No full textThis chapter describes the long-standing tradition of soil science in Friuli Venezia Giulia, starting from the pioneers: Domenico Pecile, Domenico, Giuseppe and Egidio Feruglio. Their work laid the foundation for following activities, mainly due to the presence of Alvise Comel, most prominent figure in soil studies in the region. A broad description follows on the evolution of local soil studies from its historical roots in the two agricultural research structures founded around 1870 in Gorizia and Udine up to present days, where ERSA and CREA still maintain a soil branch in their institutional activity. The foundation of the University of Udine (1976) and ARPA (1998) enriched the regional scene of soil science research
Direct oral anticoagulants use in elderly patients with non valvular atrial fibrillation. state of evidence
No full textNon-valvular atrial fibrillation (NVAF) increases the risk of stroke by three-to five-fold, especially in elderly patients, creating a huge burden on medical system as well as a negative impact on patients' lives. Balancing efficacy and bleeding risk is a challenge when considering anticoagulation therapy in elderly patients, because of their frequent high risk of both stroke and bleeding. Real world data reveal the underuse of anticoagulation in the elderly, especially due to physicians' fear of bleeding, often neglecting the thromboembolic risk. Care of elderly patients with NVAF is often complicated by factors including adherence, cognitive impairment, health literacy, risk of falling, adverse effects, involvement of caregivers, and patient-physician relationship. Therefore, shared decision making and conversations between clinicians and patients are crucial. In addition, elderly patients often suffer from multiple comorbidities, requiring multiple concomitant medications, with an increased risk of drug interactions. Four non-Vitamin K antagonist oral anticoagulants, the so-called direct oral anticoagulants (DOACs) - dabigatran, rivaroxaban, apixaban and edoxaban - have been approved for reducing the risk of stroke and systemic embolism in patients with NVAF. Clinical trials and real-world data show the advantages of this class of drugs compared to conventional anticoagulation in the treatment of elderly patients with NVAF and identify subgroups of older patients who may be more suitable candidates for particular agents. However, there are conflicting opinions on the absolute benefit of DOACs use in elderly patients. A key factor to consider is that elderly patients frequently suffer from renal impairment and therefore dose adjustments according to creatinine clearance are mandatory for DOACs. As each DOAC comes with its own unique advantages and safety profile, a personalized case by case approach should be adopted to decide on the appropriate anticoagulation regimen for elderly patients after weighing the overall risks and benefits of therapy
Role of central endogenous opiate system in patients with sindrome x
No full textBACKGROUND: To evaluate the role of the endogenous opioid system (EOS) in abnormal pain perception in patients with syndrome X, we used a neuroendocrine approach, evaluating plasmatic luteinizing hormone (LH) changes after naloxone, a competitive antagonist of opioid receptors able to unblock tonic EOS inhibition on gonadotropin release. Thus LH response to naloxone test indicates the central EOS activity on hypothalamic luteinizing hormone-releasing hormone (LH-RH) inhibitory opioid receptors.
METHODS: Ten patients with syndrome X, 10 age-matched male patients with coronary artery disease (CAD), and 10 normal subjects were analyzed. Naloxone tests were performed between 8 and 9 am. Basal beta-endorphin and LH levels were determined on 4 blood samples at 20-minute intervals; after naloxone (0.1 mg/kg intravenously in 4 minutes), LH was measured on 8 samples at 15-minute intervals. In all patients the test was also performed after LH-RH administration. Anginal pain on exercise testing was subjectively scored on a 1 to 10 analogic scale and wall motion abnormalities were quantified by a wall motion score index.
RESULTS: Significant differences were found in LH release after naloxone (CAD 260.3 +/- 42.6 vs syndrome X 151.6 +/- 48.5 mIU/mL, P <.05), angina score (CAD 5.5 +/- 1.3 vs syndrome X 7.2 +/- 1.7, P <.05), and wall motion abnormalities (CAD 3.6 +/- 1. 2 vs syndrome X 2.8 +/- 1.9, P <.05).
CONCLUSIONS: The reduced LH release after naloxone in syndrome X, with a normal LH-RH response, suggests a lower central EOS activity, which may be related to the higher anginal pain perception
Personal Care Products as a Contributing Factor to Antimicrobial Resistance: Current State and Novel Approach to Investigation
No full textAntimicrobial resistance (AMR) is one of the world’s industrialized nations’ biggest issues. It has a significant influence on the ecosystem and negatively affects human health. The overuse of antibiotics in the healthcare and agri-food industries has historically been defined as a leading factor, although the use of antimicrobial-containing personal care products plays a significant role in the spread of AMR. Lotions, creams, shampoos, soaps, shower gels, toothpaste, fragrances, and other items are used for everyday grooming and hygiene. However, in addition to the primary ingredients, additives are included to help preserve the product by lowering its microbial load and provide disinfection properties. These same substances are released into the environment, escaping traditional wastewater treatment methods and remaining in ecosystems where they contact microbial communities and promote the spread of resistance. The study of antimicrobial compounds, which are often solely researched from a toxicological point of view, must be resumed considering the recent discoveries, to highlight their contribution to AMR. Parabens, triclocarban, and triclosan are among the most worrying chemicals. To investigate this issue, more effective models must be chosen. Among them, zebrafish is a crucial study system because it allows for the assessment of both the risks associated with exposure to these substances as well as environmental monitoring. Furthermore, artificial intelligence-based computer systems are useful in simplifying the handling of antibiotic resistance data and speeding up drug discovery processes
Agrobacterium tumefaciens-mediated introduction of polygalacturonase inhibiting protein 2 gene (pvpgip2) from Phaseolus vulgaris into sugar beet (Beta vulgaris L.)
No full textSugar beet (Beta vulgaris L.) is an important industrial crop, the yield of which is strongly affected by numerous diseases caused by fungal pathogens. To the aim of developing transgenic plants resistant to fungi, two transgenic diploid sugar beet genotypes expressing the gene encoding the polygalacturonase inhibiting protein 2 of Phaseolus vulgaris (PvPGIP2) were generated by Agrobacterium tumefaciens-mediated transformation. PGIPs are plant cell wall leucine-rich repeat (LRR) proteins that bind to and inhibit fungal polygalacturonase (PG), thus slowing down the plant cell wall degradation and limiting fungal colonization of the plant tissues. Leaf blade explants carrying the bases of regenerated shoots, a highly regenerative tissue, were used for transformation. PCR screening using specific primers showed the presence of the transgene in more than 40% of the regenerated kanamycin-resistant plants. A transformation rate of 4.4-4.2% (depending on the genotype) was achieved as revealed by agarose diffusion assay of the PvPGIP2 activity in the crude protein extracts of shoot tissues. The intact integration of the transgene cassette into the genome was confirmed by Southern blot analysis. The inhibitory activity against Fusarium phyllophilum polygalacturonase (FpPG) was found at various levels in several transgenic plants. No alterations of growth and development of the transgenic plants were observed
Agrobacterium tumefaciens-mediated introduction of polygalacturonase inhibiting protein 2 gene (pvpgip2) from Phaseolus vulgaris into sugar beet (Beta vulgaris L.)
No full textSugar beet (Beta vulgaris L.) is an important industrial crop, the yield of which is strongly affected by numerous diseases caused by fungal pathogens. To the aim of developing transgenic plants resistant to fungi, two transgenic diploid sugar beet genotypes expressing the gene encoding the polygalacturonase inhibiting protein 2 of Phaseolus vulgaris (PvPGIP2) were generated by Agrobacterium tumefaciens-mediated transformation. PGIPs are plant cell wall leucine-rich repeat (LRR) proteins that bind to and inhibit fungal polygalacturonase (PG), thus slowing down the plant cell wall degradation and limiting fungal colonization of the plant tissues. Leaf blade explants carrying the bases of regenerated shoots, a highly regenerative tissue, were used for transformation. PCR screening using specific primers showed the presence of the transgene in more than 40% of the regenerated kanamycin-resistant plants. A transformation rate of 4.4-4.2% (depending on the genotype) was achieved as revealed by agarose diffusion assay of the PvPGIP2 activity in the crude protein extracts of shoot tissues. The intact integration of the transgene cassette into the genome was confirmed by Southern blot analysis. The inhibitory activity against Fusarium phyllophilum polygalacturonase (FpPG) was found at various levels in several transgenic plants. No alterations of growth and development of the transgenic plants were observed
Correction to: Safety and Psychological Outcomes of Tandem t:Slim X2 Insulin Pump with Control-IQ Technology in Children, Adolescents, and Young Adults with Type 1 Diabetes: A Systematic Review
No full textThe second author name was incorrectly published as Giula Maria Smylie. The correct name is Giulia Marie Smylie. The original article has been corrected
Mediterranean Diet and Metabolic Syndrome: a dietary intervention study to reduce metabolic syndrome risk after heart transplantation.
No full textBackground: heart-transplanted (HTx) patients are inclined to develop the Metabolic Syndrome (MetS), mainly due to the side effects of immunosuppressive therapy. The Mediterranean Diet (MD) has proven effective preventing MetS in general population.
Aim: to assess the impact of a dietary intervention based on MD in HTx patients with high risk of MetS.
Methods: 21 HTx patients were enrolled and randomly assigned in an intervention (IG) or in a control group (CG). IG received personalised dietary advices based on MD along 3 meetings (baseline, at 6 and 12 months). CG received general dietary indications based on Italian guidelines for a healthy nutrition at baseline (1). A validated 15-item questionnaire (2) was administered to assess the MD adherence, at each timepoint to IG and at baseline and after 6 months to CG. The MD score ranged from 0 to 9 (minimal-maximal adherence). Data on MetS criteria were collected from clinical informatic system (study approved by the Ethics Committee of Friuli Venezia Giulia Region).
Results: 11 patients were included in IG and 10 in CG. At baseline, 46% patients of the IG resulted affected by MetS vs 20% of the CG (p=0.221). IG patients showed more hypertriglyceridemia (100% vs 70%, p=0.09), while the other MetS criteria were comparable. MD score was low and similar between groups (4±2 vs 4±2, p=0.918). At 6 months, MD score of IG become higher than CG (5±2 vs 4±1, p=0.169) and blood pressure (BP) expressed in mmHg (median, 25th-75th) resulted significantly lower (systolic BP 130, 120–130 vs 145, 130–147, p=0.020; diastolic BP 80, 75–80 vs 86, 83–90, p=0.004). In addition, fasting glucose (84±10mg/dL vs 94±18mg/dL, p=0.133) and triglycerides (87±38mg/dL vs 113±41mg/dL, p=0.153) were found lower in IG. At 12 months, in IG adherence to MD increased significantly compared with the baseline (7±1.3 vs 4±1.5, p=0.001) and waist circumference was reduced on average of 1.3±2.6 cm.
Conclusions: despite the small sample size due to COVID-19, the dietary intervention providing specific dietary advices based on MD principles, may exert many beneficial effects on MD adherence and MetS criteria of HTx patients.
1. CREA, 2018.
2. Gnagnarella P., Nutr. Metab. Cardiovasc., 2018, 28: 1140-1147
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