44,092 research outputs found
Stellar disks and embedded bars in early-type galaxies
No full textWe present photometric disk-bulge
decompositions of 28 southern early-type galaxies with types in
either the
RC3 or ESO-Lauberts & Valentijn catalogues.
The
decomposition method applied here is based on that
developed by Scorza & Bender (1995) but the improved version allows
for arbitrary surface brightness profiles of the disk models.
We find three types of objects in this sample:
bulge-dominated systems, with fully embedded close to edge-on disks;
disk-dominated close to edge-on objects and
objects with barred disks being modestly inclined down to face-on.
Like in Scorza & Bender (1995), the analysis made here indicates
that the superposition of a thin disk and an elliptical bulge can give
good account for the morphology of most of the galaxies. We find the
disks to have a diversity of surface brightness profiles, the most
frequent case being that of a disk with an exponential profile, which
becomes steeper at small radii. After disk subtraction, the bulges
follow more closely the law.
Five of the galaxies show signatures of embedded bar components.
These have flat
surface brightness profiles at small radii and rectangular shape, which are
typical features of barred early-type galaxies.
We find that the properties of the galaxies, most notably the
disk-to-total ratio, correlates only modestly with the original
classification of the galaxies
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
Bender elements: bad source - good receiver
No full textShear wave velocity measurement in the laboratory, by means of Bender Elements is becoming more and more popular for geotechnical characterization. The reasons of the increasing popularity of such method are well known and among the many the “apparent” simplicity of the testing method should be mentioned. Anyway, several researchers have pointed out the difficulties in interpreting test results. Difficulties are mainly due to the fact that real test conditions mismatch the given assumptions.
The paper clearly shows, using laser measurements, that a source-bender, excited by a sine wave, oscillates non-symmetrically showing a waveform very different than the electrical input. This make questionable the possible use of cross-correlation (referring to the input waveform).
On the other hand the source-bender does not bend as a cantilever when using high input frequencies. Under such circumstances, deformation mode of the BE becomes very complex and a very complex wave field is generated. Numerical simulations clearly show what above indicated.
The authors conclude suggesting the use of BE only as receivers; generation of the wave motion should be accomplished with other means
C-structures and f-structures for the British national corpus
No full textWe describe how the British National Corpus (BNC), a one hundred million word balanced corpus of British English, was parsed into Lexical Functional Grammar (LFG) c-structures and f-structures, using a treebank-based
parsing architecture. The parsing architecture uses a state-of-the-art statistical parser and reranker trained on the Penn Treebank to produce context-free phrase structure trees, and an annotation algorithm to automatically annotate
these trees into LFG f-structures. We describe the pre-processing steps which were taken to accommodate the differences between the Penn Treebank and the BNC. Some of the issues encountered in applying the parsing
architecture on such a large scale are discussed. The process of annotating a gold standard set of 1,000 parse trees is described. We present evaluation results obtained by evaluating the c-structures produced by the statistical parser against the c-structure gold standard. We also present the results obtained by evaluating the f-structures produced by the annotation algorithm against an
automatically constructed f-structure gold standard. The c-structures achieve an f-score of 83.7% and the f-structures an f-score of 91.2%
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Zur praktisch trägerfreien C und F Markierung von Dibenzodiazepinen (Clozapin) und Analogen
No full textPharmacologically active dibenzodiazepines were labelled with carbon-11 and fluorine-18, in particular the atypical neuroleptic clozapine (8-C1-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]-diazepine) for pharmakokinetic studies with positron emission tomography (PET). N. c. a. [C]clozapine was synthesized by N-methylation of the desmethyl compound norclozapine, using []methyl iodide and [C]methyl triflate for comparison. Highest radiochemical yieldsfor both methylation agents were better than 90%, based on the trapped [C]methylation reagent. However, reaction conditions were milder when using [C]methyl triflate. The radiochemical purity of the isolated [C)clozapine exceeded 98%, and the specific activity was in the range of 92 - 130 GBq/mol (2.5 -3.5 Ci/mol). Selective [C]methylation of the second amino function, the dibenzodiazepine amino function, was achieved by using a BOC protected derivative of norclozapine as precursor. As [C]methylation reagent in situ prepared [C]methyl triflate was used. Methylation and subsequent removal of the protective group with iodotrimethylsilane were carried out in chloroform as a two step one-pot reaction. Radiochemical yields of about 40% of the desired product were obtained within 15 min. Subsequent oxidation of [C]clozapine with m-chloroperoxybenzoic acid yielded n. c. a. [C]clozapine-N-oxide, the major metabolite of clozapine, With [C]methyl triflate as methylation reagent the synthesis was carried out as a two step one-pot reaction. The oxidation was completed within 2 min at 2°C. A fluorine-18 labelled analogue of clozapine was synthesized by the reaction of norclozapine with the [F]fluoroethylation reagent 1- [F] Fluoro-2-tosyloxyethane. 1- [F] Fluoro-2-tosyloxyethane was prepared by nucleophilic fluorination using 1,2-bistosyloxyethane, and tetramethylammonium hydrogen carbonate as an anion activator in acetonitrile. The [F]fluoroethylated product was obtained in radiochemical yields of about 70% within 20 min at 80°C
Six Overtures Composed by C. F. Abel. Adapted for the Harpsichord or Piano Forte : being Opera First / By the Author
No full textSIX OVERTURES COMPOSED BY C. F. ABEL. ADAPTED FOR THE HARPSICHORD OR PIANO FORTE : BEING OPERA FIRST / BY THE AUTHOR
Six Overtures Composed by C. F. Abel. Adapted for the Harpsichord or Piano Forte : being Opera First / By the Author (1)
Cover (1)
Titelseite (2)
Overture I. (3)
Overture II. (8)
Overture III. (12)
Overture IV. (16)
Overture V. (20)
Overture VI. (24
Lympha technique for primary and early secondary prevention of lymphedema following cancer treatment
No full textLYMPHA proved to be an effective preventive procedure that contributes in giving our oncological patients a good quality of life. In this presentation, the author will report indications, technical aspects and benefits of LYMPHA technique
Complex pattern of HTLV-2 splicing and expression in PBMCs from infected patients
No full textHTLV express multiple gene products from the same coding region by employing different strategies, including alternative splicing. Our investigations were focused on the analysis of the levels of expression of different HTLV-2 transcripts, to test their temporal expression at different stages of viral cycle and their quantitation by real time RT-PCR, in infected cell lines and in primary cultures of PBMCs from infected subjects.
An early transcription of tax/rex regulatory mRNA was observed, followed by a gradual and steady increase of gag/pol and env structural transcripts and of other accessory mRNAs. We identified a novel 3’ splice acceptor site, used by both HTLV-2 A and B subtypes to generate alternative doubly spliced mRNAs within the pX region and also a novel env isoform preferentially expressed in 2B subtypes and behaving as a late gene. Among the singly spliced mRNAs coding for other accessory proteins, the p28, p22/p20-II isoform was found to be highly expressed as compared to its alternative p28, p22/p20-I form. The APH-2 transcript from the negative strand behaved as a late gene in stably infected cells, while in ex-vivo PBMCs its kinetics appeared to be variable so that a clear pattern of expression was not yet assessed.
In conclusion, the temporal transcription of different HTLV-2 transcripts follows a distinct expression pattern: tax/rex is the first mRNA to be expressed, thus indicating that it is necessary at the beginning of the infection cycle to transactivate and regulate viral and cellular transcripts, while gag/pol and env structural genes are expressed later in the viral cycle
Time course of Human-T cell Leukemia Virus type 2 (HTLV-2) gene expression in PBMCs from infected patients
No full textThe analysis of HTLV expression during the infection process is essential to understand the influence of viral gene products in proliferation, cell cycle and signalling. Very little information has so far been obtained on the quantification and timing of HTLV-2 viral transcription, therefore the aim of the study was to further investigate the kinetics of different HTLV-2 transcripts.
The time course of transcription of the viral mRNAs, tax/rex, gag/pol, env, p28- p22/p20 rex-1 and -2, p10/p11 and p?, was evaluated using splice-junction-specific primers to quantify all HTLV-2 transcripts by real time RT-PCR. To this end, PBMCs from HTLV-2B infected patients were cultured with IL-2 and mRNA analysed at different time points: 0, 2, 4, 8, 21 and 48 hours. The results obtained showed an early transcription of tax/rex, followed by p28- p22/p20 rex-2 and by a gradual and steady increase of gag/pol and p28- p22/p20 rex-1. The level of expression of gag/pol and p28- p22/p20 rex-2 was about 103-104 fold higher than tax/rex and p28- p22/p20 rex-1.
These results indicate that the expression of different HTLV-2 genes follows a distinct timing in PBMCs isolated from infected patients. The regulatory transcripts are the first to be expressed whereas structural ones are expressed at a later time point. Moreover, the level of expression of accessory genes was significantly lower than that of structural viral genes.
In conclusion, distinct patterns of expression of HTLV-2 were found in infected PBMCs thus indicating that the control of gene transcription is highly regulated both in its kinetics and expression
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