1,721,134 research outputs found
PRGF in the cartilage defects in the knee joint
No full textIn the last few years the improvements of biotechnology allowed the development of new techniques for the stimulation and the acceleration of tissue healing and bone regeneration, particularly of platelet-rich therapies. The progressive knowledge of the tissuetal phases after a traumatic injury showed the role of a range of growth factors and cytokines, secreted by serum and degranulating platelets, in the repair process. Every growth factor such as PDGF, TGF-beta, IGF-1 and VEGF has a specific function, but for the healing of the tissue the release of the pool of these growth factors is important. The platelets may be considered like a reservoir of growth factors; among the platelet-rich preparations, the importance of platelet release growth factor (PRGF) was given by their versatility. The effect of these preparations is not only mytogenic, but also an angiogenic effect, antibacterial and anti-inflammatory. In clinical fields, PRGF, often associated to some biomaterials, can be used for the treatment of chronic ulcers and for bone and soft tissue regeneration. Particularly in orthopaedic field, PRGF accelerate healing process and avoid further degeneration of the bone, the cartilage, the tendons and the ligaments. For example, platelet-rich preparations can be used during a tendon suture or a ligament reconstruction (ACL) or, finally, for the treatment of tissue avascular like the cartilage with the purpose of an acceleration in functional recovery. The arthroscopic repair of chondral lacerations or meniscus tears represents the future step of these versatile preparations. Symptomatic cartilage defects in the knee joint have aroused attention and clinical interest in recent years because these lesions can be difficult to treat. Despite the fact that, biological surgery of the past had poor consistent results, now there is a new interest for these techniques, particularly for platelet-related-growth-factors (PRGF). The recent improvement of tissue engineering and the biological innovation of biomechanical properties of the materials used (matrix scaffolds, cartilage grafts, growth factors and genetic engineering) have increased the research in the cartilage resurfacing and hyaline tissue regeneration
Proteoglycan and alcyan blue complexes on thin sections and on freeze-etching and shadow-casting replicas
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Biocompatibilità e osteoconduzione di superfici accoppiate Idrossiapatite e Titanio:Studio sperimentale.
No full textCase report 381: Membranous lipodystrophy (MLD).
No full textThis disease was recognized for the first time by Jarvi in 1964
and named "Hereditary Folycystic Osteodysplasia (HPO)" [5].
In 1973, Nasu et al. [6] reported an autopsied case that pre-
sented the same features as HPO and because of the histological
findings, the authors of that manuscript called the entity
"Membranous Lipodystrophy". Up to the present time only
27 cases have been reported in the world literature, exclusively
in four countries - Finland, Japan, Norway and the USA [1-7].
Mental changes and corresponding lesions of the central
nervous system have been associated often with MLD [1, 3,
6], but the relationship between pathological changes in the
skeleton and brain remains unclear. The etiology of the disease
is unknown. Hakola [3] reported three affected members in
the same family, but this observation was not confirmed in
other reports.
In summary, a fascinating case of an entity called "mem-
branous lipodystrophy" has been described in a 35-year-old
woman. Multiple, cyst-like disseminated, skeletal lesions were
present throughout (except for the spine, innominate bones,
ribs and skull). In addition, resorption of bone and a very
thin periosteum were identified. Coarse and irregular trabeculae
also were noted. Associated with the skeletal lesions in this
instance, were hydrocephalus, cerebral cortical atrophy and
multiple calcifications in the basal ganglia bilaterally.
The development of mental changes and lesions of the cen-
tral nervous system as indicated are said to be associated con-
sistently with MLD. The cause of the disorder is considered
to be unknown.
The pathological studies were described in depth and the
differential diagnosis was considered.
It is believed by the editor that this case report, describing
this entity, is a significant contribution to the literature on a
disease of great interest, probably unknown to many pphysicians
L’epidermo-fascio-osteoplastica nel trattamento delle gravi pseudoartrosi infette di gamba con perdita di sostanza ossea e delle parti molli
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