54 research outputs found
sj-pdf-1-neu-10.1177_19714009211049080 - Supplemental material for Acquired pial arteriovenous fistula secondary to cerebral cortical vein thrombosis: A case report and review of the literature
No full textSupplemental material, sj-pdf-1-neu-10.1177_19714009211049080 for Acquired pial arteriovenous fistula secondary to cerebral cortical vein thrombosis: A case report and review of the literature by Skander Sammoud, Nadia Hammami, Dhaker Turki, Fatma Nabli, Samia Ben Sassi, Samir Belal, Cyrine Drissi and Mohamed Ben Hamouda in The Neuroradiology Journal</p
Supplemental material for Stroke in the Middle-East and North Africa: A 2-year prospective observational study of stroke characteristics in the region—Results from the Safe Implementation of Treatments in Stroke (SITS)–Middle-East and North African (MENA)
No full textSupplemental Material for Stroke in the Middle-East and North Africa: A 2-year prospective observational study of stroke characteristics in the region—Results from the Safe Implementation of Treatments in Stroke (SITS)–Middle-East and North African (MENA) by Suhail Al Rukn, Michael V Mazya, Faycal Hentati, Samia Ben Sassi, Fatma Nabli, Zakharia Said, Belahsen Faouzi, Husnain Hashim, Foad Abd-Allah, Benhan Mansouri, Selma Kesraoui, Souheil Gebeily, Husen Abdulrahman, Naveed Akhtar, Niaz Ahmed, Nils Wahlgren, Hany Aref, Mohammed Almekhlafi and Tiago Moreira: for the Stroke Emergency Mobile (STEMO) Consortium in International Journal of Stroke</p
Increased T-bet/GATA-3 and ROR-γt /Foxp3 Ratios in Cerebrospinal Fluid as Potential Criteria for Definite Neuro-Behçet’s Disease
No full textWhen the central nervous system (CNS) is the primary affected site in an initial attack of Behçet’s disease (BD), the differential diagnosis is particularly challenging. Some cases remain unclassified or qualified as probable neuro-Behçet’s disease (NBD). Several cytokines are involved in the immunopathogenesis of this disease; however, studies establishing the differential cytokine pattern between probable and definite NBD are scarce. Twenty-eight parenchymal NBD patients, diagnosed according to the International Consensus Recommendation (ICR) criteria and classified into definite (D-NBD; n = 17) and probable (P-NBD; n = 11), were sampled at their first neurological symptoms, and compared with healthy control subjects (n = 20). Oligoclonal bands (OCB) of IgG were detected by isoelectric focusing on agarose, and immunoblotting of matched serum and cerebrospinal fluid (CSF) sample pairs. T cell cytokines (INF-γ, IL-4, IL-17, and IL-10) and transcription factors related to Th1, Th2, Th17, and T regulatory populations (respectively T-bet, GATA-3, ROR-γt, and Foxp3) were studied by quantitative RT-PCR in peripheral blood mononuclear cells (PBMCs) and CSF cells. Inflammatory cytokines such as IL-6, TNF-α, and IL-1β were also analyzed. CSF OCB pattern 2 was present in only 1 out of 28 neuro-Behçet’s patients who belonged to the P-NBD group. Two D-NBD patients had OCB in CSF showing pattern 4. In the D-NBD CSF samples, IL-17 and IL-10 expressions were significantly elevated compared to P-NBD. Moreover, D-NBD patients had increased levels of T-bet/GATA-3 and ROR-γt/Foxp3 ratios compared to P-NBD. Furthermore, a significant increase of CSF IL-6 in D-NBD, compared to P-NBD and the controls, was found. In addition to the increased IL-6 level, the data obtained suggest the existence in D-NBD patients of a significantly disrupted balance between Th17 effector and T regulatory cells, as reflected by the enhanced ROR-γt/Foxp3 ratio. This could be considered as an additional criterion for definite neuro-Behçet’s disease
Extending brainstem and capsule-thalamic lesions in a patient with parenchymal neuro-Behçet disease
No full text
The Evolution of Genetic Variability at the LRRK2 Locus
No full textLeucine-rich repeat kinase 2 (LRRK2) c.6055G>A (p.G2019S) is a frequent cause of Parkinson’s disease (PD), accounting for >30% of Tunisian Arab-Berber patients. LRRK2 is widely expressed in the immune system and its kinase activity confers a survival advantage against infection in animal models. Here, we assess haplotype variability in cis and in trans of the LRRK2 c.6055G>A mutation, define the age of the pathogenic allele, explore its relationship to the age of disease onset (AOO), and provide evidence for its positive selection
L’accident vasculaire cérébral secondaire à une dissection artérielle vertébrale : complication rare de l’éclampsie
No full textNeuromyélitie optique (NMO) et spectre NMO (SNMO) : caractéristiques cliniques, radiologiques et évolutives d’une série Tunisienne
No full textÉtude comparative entre les ataxies de type AOA1 et AOA2 : à propos d’une cohorte tunisienne
No full text- …
