119,986 research outputs found
Assemblée dans le désert : Bienhereux sont ceux qui écoutent la parole de Dieu, et qui la pratiquent J.C. en S. Luc chapitre XI. verset 28
No full textAn einem geheimen Versammlungsort ausserhalb von Ortschaften (au désert) predigt ein Wanderprediger auf einer improvisierten Kanzel zu einer Gruppe Hugenotten. Im Hintergrund sind an Bäumen festgemachte Pferde erkennbarJ.J. Storni invenit & p. ; L. Bellotti sculpsi
Forecasting and Stress Testing Credit Card Default with Dynamic Models
No full textTypically models of credit card default are built on static data, often collected at timeof application. We consider alternative models that also include behavioural dataabout credit card holders and macroeconomic conditions across the credit cardlifetime, using a discrete survival analysis framework. We find that dynamic modelsthat include these behavioural and macroeconomic variables give statisticallysignificant improvements in model fit which translates into better forecasts of defaultat both account and portfolio level when applied to an out-of-sample dataset. Additionally, by simulating extreme economic conditions, we show how thesemodels can be used to stress test credit card portfolios
La logica matematica in Unione Sovietica (1917-1947)
No full textSi presentano i punti salienti della prima fase (1917-1947) della storia della logica matematica sovietica, mostrando le difficoltà dell'affermarsi di questa disciplina in quel contesto storico
"Tailored" step test for a rapid, accurate and safe VO2max determination in healthy elderly
No full text“Tailored” step test for rapid, accurate and safe VO2max determination in healthy elderly.
Ceciclia Bellotti, Lorenzo Casiello, Silvia Pogliaghi
Faculty of Kinesiology, University of Verona, Italy
PURPOSE: The study aimed at developing and validating a “tailored” version of the Åstrand step test, suitable for VO2max determination in healthy elderly. Furthermore, we tested the hypothesis that a direct measure (compared to estimation) of the step test VO2, adds accuracy to VO2max determination in this population, characterized by low fitness and muscle strength and reduced coordiantive ability.
METHODS: In 27 healthy elderly (age 68+5, 14 ♂, 13 ♀) a target VO2 (tVO2) for the step test was calculated as 60% of the VO2max (predicted based on their referred activity pattern). Thereafter, subjects performed a 5-min test, on a 30 cm step, with a stepping rate (10-25 steps*min-1) “tailored” based on tVO2 and the predicted cost of stepping. Heart rate (HR) and VO2 were measured using a portable, hand-held, metabolic analyzer. VO2max was estimated based on Åstrand equation and age correction using either tVO2 (t-estVO2max) or measured VO2 (m estVO2max). Finally, VO2max was measured directly (dVO2max) during an incremental cycling test to exhaustion with breath by breath determination of cardiorespiratory variables, with a traditional metabolic chart. Agreement among t estVO2max, m estVO2max and dVO2max was evaluated by Bland Altman analysis. RESULTS: All the subjects completed the incremental exercise to exhaustion (maximal HR 98±7% of age-predicted value, maximal respiratory quotient 1.1±0.04). Mean ± standard deviation dVO2max was 27±5 ml*kg-1*min-1. All the subjects were also able to complete the “tailored” step test with no difficulty. m estVO2max was not significantly different from dVO2max (bias -0.3, not different from 0; precision 4.1 ml*kg-1*min-1). On the contrary, t-estVO2max was significantly underestimated compared to dVO2max (bias -2.3, ≠ 0; precision 4.6 ml*kg-1*min-1).
CONCLUSION: The study developed and validated a “tailored” version of the Åstrand step test, suitable for a rapid (5 min duration), safe (submaximal test) and accurate (unbiased) VO2max determination in healthy elderly individuals. In this population, estimation of the step test VO2 leads to a small (9%) yet significant error in VO2max estimation. Therefore, our data suggest that a direct measure of the step test VO2 should be performed to assure accuracy to VO2max.estimation.
The study was supported by Cosmed, Italy
AA amyloidosis without systemic inflammation: when clinical evidence validates predictions of experimental medicine
No full textAmyloid A (AA) amyloidosis is a well-known consequence of chronic inflammatory diseases in which elevated plasma concentrations of serum amyloid A result in amyloid aggregation and organ damage. In this issue, Sikora et al. report, for the first time, an inherited form of AA amyloidosis occurring in the absence of systemic inflammation. This finding may provide novel insights into the pathogenesis of AA amyloidosis, allowing researchers to further dissect the role of inflammation from that of serum amyloid A
Support Vector Machines for Credit Scoring and discovery of significant features
No full textThe assessment of risk of default on credit is important for financial institutions. Logistic regression and discriminant analysis are techniques traditionally used in credit scoring for determining likelihood to default based on consumer application and credit reference agency data. We test support vector machines against these traditional methods on a large credit card database. We find that they are competitive and can be used as the basis of a feature selection method to discover those features that are most significant in determining risk of default
Sintesi e numero nell'ultimo Cassirer
No full textIn questa breve nota discutiamo alcuni aspetti di una nozione in senso lato kantiana di sintesi, evidenziati da Ernst Cassirer nella fase finale del suo pensiero specificamente in rapporto alla questione della definizione del concetto di numero, mostrando quali conseguenze ne tragga l’autore, ad esempio limitando decisamente il ruolo logico della sussunzione nelle proposizioni matematiche
The second-order alternative in set theory
No full textThe paper discusses the natural second-order alternative to the 'weak' first-order formal systems of axiomatic set theory by focusing on the entangled relationship between second-order theories and first-order set theory. On the basis of a survey of some classical disputes on the problem, I argue that second-order logic is actually set theory in disguise, unless one has an independent notion of 'collection' or of 'property'. Moreover, I argue that if one does not have at one's disposal such independent notions then second-order logic may still be significant for set theory only if one presupposes that the powerset operation is completely determined independently of any axiomatization. I maintain that the philosophical price of both these options is too high
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