2,020 research outputs found
Fostering innovation across aerospace supplier networks
No full textThesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering; and, (S.M.)--Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2002.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections."June 2002." Page 187 blank.Includes bibliographical references (p. 180-184).by Aaron L. Kirtley.S.M
Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
No full textCorrection to: Nature Genetics https://doi.org/10.1038/ng.3668, published online 26 September 2016.
In the version of the article published, the surname of author Aaron Isaacs is misspelled as Issacs
Harvest of thoughts. By Aaron Belford Thompson ... With an introduction by James Whitcomb Riley. Illustrated by G.T. Haywood.
No full text[3] l., 110 p
Co-opting disease pathology for personalized medicine; utilizing endogenous biomaterials to generate theranostic nanoparticles
No full textVarious biomolecules and cell types have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid (HAuCl4) is introduced.We have demonstrated the capacity and utility of nanoparticles generated from endogenous biomolecules through three examples which can potentially be applied to multitudes of applications (1) Through a point of care reactive gel, acting as a scaffold for ionic gold (Au3+) capable of sensing reductive biomolecules presented in high concentrations during eye injury; (2) The generation of gold nanoparticles intrecellularly for enhanced phenotype observation of the cell combined with therapeutic potential; and (3) A simplistic, single-step means of generating gold nanoparticles functionalized with whole cell membrane which imparts minimal impact on biomolecule integrity. From this body of works we have demonstrated that multitudes of endogenous biomaterials have the capacity to reduce and form nanoparticles by variety of mechanisms which can directly be applied to sensing pathological states, applying therapy, as well as a means for improvement on previous biomimetic theranostics.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01The student, Aaron Schwartz-Duval, accepted the attached license on 2018-12-14 at 15:30.The student, Aaron Schwartz-Duval, submitted this Dissertation for approval on 2018-12-14 at 15:36.This Dissertation was approved for publication on 2019-01-02 at 11:26.DSpace SAF Submission Ingestion Package generated from Vireo submission #13333 on 2019-08-22 at 16:18:18Made available in DSpace on 2019-08-23T20:44:21Z (GMT). No. of bitstreams: 3
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Single- and Multi-carrier Quadrature Amplitude Modulation: Principles and Applications for Personal Communications, WATM and Broadcasting: 2nd
No full textSingle- and Multi-carrier Quadrature Amplitude Modulation Principles and Applications for Personal Communications, WLANs and Broadcasting L. Hanzo Department of Electronics and Computer Science, University of Southampton, UK W. Webb Motorola, Arlington Heights, USA formerly at Multiple Access Communications Ltd, Southampton, UK T. Keller Ubinetics, Cambridge Technology Centre, Melbourn, UK formerly at Department of Electronics and Computer Science, University of Southampton, UK Motivated by the rapid evolution of wireless communication systems, this expanded second edition provides an overview of most major single- and multi-carrier Quadrature Amplitude Modulation (QAM) techniques commencing with simple QAM schemes for the uninitiated through to complex, rapidly-evolving areas, such as arrangements for wide-band mobile channels. Targeted at the more advanced reader, the multi-carrier modulation based second half of the book presents a research-orientated outlook using a variety of novel QAM-based arrangements. * Features six new chapters dealing with the complexities of multi-carrier modulation which has found applications ranging from Wireless Local Area Networks (WLAN) to Digital Video Broadcasting (DVB) * Provides a rudimentary introduction for readers requiring a background in the field of modulation and radio wave propagation * Discusses classic QAM transmission issues relevant to Gaussian channels * Examines QAM-based transmissions over mobile radio channels * Incorporates QAM-related orthogonal techniques, considers the spectral efficiency of QAM in cellular frequency re-use structures and presents a QAM-based speech communications system design study * Introduces Orthogonal Frequency Division Multiplexing (OFDM) over both Gaussian and wideband fading channels By providing an all-encompassing self-contained treatment of single- and multi- carrier QAM based communications, a wide range of readers including senior undergraduate and postgraduate students, practising engineers and researchers alike will all find the coverage of this book attractive
Economics of yellow mustard in the Pacific Northwest
No full textBulletin no. 826 Moscow, Idaho :University of Idaho, College of Agriculture, Cooperative Extension System, 2000-06-01. Author(s): Withers, Russell; Berglund, Steve; Esser, Aaron; Brown, Jack; Smathers, Bo
Richardson, Barbauld, and the construction of an early modern fan club
No full textMPhilMuch has been written about the life and long works of the eighteenth century epistolary novelist, Samuel Richardson, but the prospect of his position as the first celebrity novelist – responsible for courting his own fame as well as initiating his own fan club – has largely been ignored. The body of manuscripts housed at the National Art Library in the Victoria and Albert Museum in London provides the modern scholar with evidence of the skeletal beginnings of an early fan club. This thesis aims to show how these manuscripts were turned into a saleable commodity by the publisher and entrepreneur Richard Phillips, while under the guiding hand of another, slightly later, literary celebrity, Anna Laetitia Barbauld. In order to restore Richardson’s reputation amongst a new nineteenth century audience, Barbauld was required to construct her own idea of him as an eighteenth century celebrity author, and in doing so the insecurities of a self-professed, apparently diffident man, are revealed. Barbauld’s capacious, but heavily edited selection of letters is analyzed in this thesis, providing ample evidence that Richardson’s correspondents were more than just eager letter writers. By using Barbauld’s biography of Richardson this thesis aims to show how she manipulates the genre of life writing in her construction of him.
This thesis offers an alternative reading of how the Richardson manuscripts are viewed, redefining them as not simply a collection of letters, but as a collective entity, deliberately selected and archived as evidence of an early modern fan club, and its celebrity managing director
Using a classic paper by Bell as a platform for discussing the role of corollary discharge-like signals in sensory perception and movement control
No full textDecades of behavioral observations have shown that invertebrate and vertebrate species have the ability to distinguish between self-generated afferent inputs versus those that are generated externally. In the present article, I describe activities focused around the discussion of a classic American Physiological Society paper by Curtis C. Bell that lays the foundation for students to investigate the neural substrate underlying this ability. Students will leave this activity being able to 1) describe the technical aspects and limitations of an electric fish preparation commonly used to acquire single unit (extracellular) neurophysiological data, 2) provide physiological evidence showing that the activity of principal cells in the posterior lateral line lobe of the electric fish brain reflects that of a reafference comparator that could be used in dissociating self-generated versus externally generated sensory signals, and 3) knowledgeably discuss hypotheses concerning the role of corollary discharge and cerebellar-like structures in vertebrate and invertebrate species. The skills and background knowledge gained in this activity lay the platform for advanced study of scientific investigations into sensory, motor, and cognitive processes in undergraduate, graduate, or medical school curricula. © 2014 The American Physiological Society
Open-label dose-finding trial of buprenorphine implants (Probuphine)(R) for treatment of heroin dependence
No full textData source: Figures, https://doi.org/10.1016/j.drugalcdep.2009.03.008Buprenorphine, a -opioid receptor partial agonist, has been shown to be safe and effective for treatment of opioid dependence. A novel implantable formulation of buprenorphine (Probuphine®), using a polymer matrix sustained-release technology, has been developed to offer treatment for opioid dependence while minimizing risks of patient noncompliance and illicit diversion. The goal of the current study was to conduct an initial, open-label, evaluation of the safety, pharmacokinetics, and efficacy of two doses of Probuphine in subjects with opioid dependence maintained on sublingual buprenorphine. Two doses of Probuphine were evaluated in 12 heroin-dependent volunteers switched from daily sublingual buprenorphine dosing to either two or four Probuphine implants based upon their buprenorphine daily maintenance dose of 8mg or 16mg respectively, and were monitored for 6 months.
Probuphine implants provided continuous steady state delivery of buprenorphine until their removal at 6 months. Withdrawal symptoms and craving remained low throughout the 6 months. For the 12 subjects, an average of 59% of urines were opioid-negative across the 6 month treatment period. Injection site reactions were present in half of patients, but none were serious. No safety concerns were evident. These results suggest that Probuphine implants offer significant promise for enhancing delivery of effective opioid substitution treatment while minimizing risk for abuse of medication.Jason White, James Bell, John B. Saunders, Paul Williamson, Maria Makowska, Aaron Farquharson, Katherine L. Beeb
Interactive Static Software Performance Analysis in the IDE
No full textDetecting performance issues due to suboptimal code during the development process can be a daunting task, especially when it comes to localizing them after noticing performance degradation after deployment. Static analysis has the potential to provide early feedback on performance problems to developers without having to run profilers with expensive (and often unavailable) performance tests. We develop a VSCode tool that integrates the static performance analysis results from Infer via code annotations and decorations (surfacing complexity analysis results in context) and side panel views showing details and overviews (enabling explainability of the results). Additionally, we design our system for interactivity to allow for more responsiveness to code changes as they happen. We evaluate the efficacy of our tool by measuring the overhead that the static performance analysis integration introduces in the development workflow. Further, we report on a case study that illustrates how our system can be used to reason about software performance in the context of a real performance bug in the ElasticSearch open-source project.Demo video: https://www.youtube.com/watch?v=-GqPb-YZMOs Repository: https://github.com/ipa-lab/vscode-infer-performanceAccepted author manuscriptSoftware Engineerin
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