23 research outputs found
Lung abcess in a child: a case report
No full textLung abcess is a rarely identified suppurative infection that has air-liquid level bigger 2 cm diameter on pulmonary graphy. It should especially be considered in the case of treatment-refractory pneumonic infections of persons with chronic diseases. In order to point out to the importance of this issue, this study presents a case of pulmonary abcess identified in a patient who was followed up due to mental - motor retardation and rehospitalized at short intervals. Our patient did not respond to parenteral antibiotic treatment, the thorax CT revealed lung abscess, chest tube insertion when the fever continue. Abscess had disappeared after 3 weeks of treatment with antibiotics
The association of serological tests and anemia in celiac disease
No full textAim: Celiac disease (CD) is a common immune-mediated enteropathy caused by gluten. These patients may apply with many different clinical forms. The aim of this study is to determine the association of serological tests and type of anemia in CD.
Methods: Totally117 biopsy proven CD patients aged between 1-17 years were included. Serological and hematological parameters of all patients were studied.
Results: Anemia was identified in 71 (60.7%) cases. Patients with anemia were diagnosed earlier than other patients (5.2±4.5 vs. 15.3±33.8 years, p=0.012). Among CD patients with anemia 39 (54.9%) were having iron deficiency, 22 (30.9%) were having folate deficiency and 10 (14%) were having vitamin B 12 deficiency. In patients with tissue transglutaminase (tTG) seropositivity serum iron levels and ferritin levels were significantly lower compared to anti-gliadin antibody (AGA) or anti-endomysium antibody (EMA) seropositivity (35±23.5 vs. 57.5±33.3, p=0.007 and 12.4±21.9 vs. 24.2±18.5, p=0.026, respectively). Low serum folate levels were more frequent in the presence of tTG seropositivity compared with AGA+EMA seropositivity (81.8% vs. 25%, p=0.015).
Conclusions: Anemia is an important cause of admission in CD. These patients are diagnosed earlier as a result of anemia. Alone tTG seropositivity is more valuable to demonstrate anemia associated with iron or folate deficiencies
Evaluation Of Children Followed Up For Nutritional Anemia In Our Hospital
No full textPurpose: Anemia is an important problem of public health that is widespread throughout the world. Although there are many different causes of anemia, nutritional causes are the most common. The aim of this study is to investigate the types of nutritional anaemias seen between the ages of 6 months and 18 years, and the characteristics affecting these anaemias in our province.
Materials and Methods: Cases diagnosed with nutritional anaemia in the paediatric outpatient clinics between 2019and 2021 were included.
Results: A total of 2187(51.9%) of the cases were girls and 1375(32.6%) were adolescents. Of 4217 subjects, 3110(73.7%) had microcytic, 781(18.5%) had megaloblastic and 326(7.7%) had mixed type anaemia. Girls had a higher total iron-binding capacity (368.6±57.5 vs. 361.7±56.9, p=0.013). Vitamin 25(OH)D serum levels were lower in megaloblastic and mixed anaemia than in microcytic anaemia (11.7 (2.3-66.7) vs. 13.9 (2.1-102), p<0.001 and 10.3 (2.3-60.8) vs. 13.9 (2.1-102), p<0.001, respectively). 216(6.9%) and 174(5.5%) patients with microcytic anaemia had malnutrition and obesity, respectively. 90(11.5%) and 42(5.4%) patients with megaloblastic anaemia had malnutrition and obesity, respectively. The incidence of malnutrition was higher in those with megaloblastic anaemia than microcytic anaemia(p=0.033).
Conclusion: Nutritional anaemia is an important problem in both adolescence and childhood. Among the types of nutritional anaemia, microcytic anaemia is the most common. Since mixed forms of these anemias can also occur, caution is required in the diagnostic phase. Microcytic anemias often occur in girls. In addition to malnutrition, a low serum level of 25(OH)D can also be a risk factor for the development of nutritional anemias
Vitamin D status in children with attention-deficit-hyperactivity disorder
No full textBekdas, Mervan/0000-0003-2469-9509; Tufan, ALI EVREN/0000-0001-5207-6240WOS: 000342836700020PubMed: 24417979BackgroundAttention-deficit-hyperactivity disorder (ADHD), one of the most common psychiatric disorders of childhood, has an early onset, affecting 2-18% of children worldwide. The etiopathogenesis of ADHD is obscure. In recent studies, a low level of vitamin D has been found in association with many disorders as well as in neuropsychiatric diseases. The aim of this study was therefore to investigate serum vitamin D level in pediatric ADHD patients. MethodsA total of 60 ADHD patients and 30 healthy controls were included in the study. The age of both groups was in the 7-18-year-old range. Serum 25-OH-vitamin D, calcium, phosphorus and alkaline phosphatase were investigated. ResultsSerum 25-OH-vitamin D was found to be significantly lower in children and adolescents with ADHD compared to healthy controls, and no significant differences were found between the groups in terms of other variables. 25-OH-vitamin D level in the ADHD group and control group was, respectively, 20.9 19.4ng/mL and 34.9 +/- 15.4ng/mL (P = 0.001). ConclusionThere is an association between lower 25-OH-vitamin D concentration and ADHD in childhood and adolescence. To the authors' knowledge this is the first study to investigate the relationship between vitamin D and ADHD in children
Investigation of celiac disease according to Marsh classification in childhood
No full textBackground: Celiac disease (CD) is an autoimmune disorder of the small intestine related to gluten. CD is diagnosed by the evaluation of histologic findings according to the Marsh classification.Objectives: To evaluate the clinical and laboratory differences of CD according to Marsh classification.Patients and method: The records of ?Marsh 2 histologically diagnosed 132 cases were evaluated.Results: It was determined that 7(5.3%) cases were Marsh 2, 32(24.2%) were Marsh 3a, 73(55.3%) were Marsh 3b, and 20(15.1%) were Marsh 3c. Vomiting in Marsh 2 was significantly lower than Marsh 3b and Marsh 3c (respectively, 14.3% vs. 56.9%, p=0.029; and 14.3% vs. 75%, p=0.005). Hemoglobin was significantly higher in Marsh 2 than Marsh 3b and Marsh 3c (respectively, 11.9±1.7 vs. 10.5±1.6 g/dl, p=0.038 and; 11.9±1.7 vs. 9.8±1.6 g/dl, p=0.005). Positive detection ratio for tTG IgA was significantly lower in Marsh 2 than Marsh 3a, Marsh 3b and Marsh 3c (respectively, 66.7% vs. 100%, p<0.001; 66.7% vs. 100%, p<0.001; and 66.7% vs. 94.1%, p=0.003). After the onset of gluten free diet, the time passed for the disappearance of tTG IgA seropositivity is significantly shorter in Marsh 2 than Marsh 3c (6±3.6 vs. 9.7±2.5 months, p=0.017).Conclusions: Gastrointestinal symptoms are more frequent in patients with severe small intestinal mucosal injury. tTG IgA seropositivity is associated with more severe disease. Clinical and laboratory findings of the patients are exacerbated when histopathological findings improve in CD.Bangladesh Journal of Medical Science Vol.16(2) 2017 p.259-265</jats:p
The predictive role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in children with simple febrile seizures
No full textAim: To evaluate the predictive roles of biochemical and complete blood count parameters in the diagnosis of febrile seizures by comparing these between patients with simple febrile seizures and febrile patients without seizures.
Methods: One hundred fifty-two children (66 girls and 86 boys), aged 6-60 months presenting with fever symptoms presenting to our hospital’s pediatric emergency department between January 2015 and January 2020 were included in the study. Demographic data, complete blood count parameters and biochemical parameter levels were compared between the two groups. These were divided into a patient group with simple febrile seizures (n = 74) and a febrile control group without seizures (n = 78).
Results: Comparison of biochemical parameters revealed significantly higher glucose, CRP, and ALT levels in the febrile seizure group, while Ca and Na were significantly lower. Comparison of complete blood count parameters revealed significantly higher white blood cell (WBC), neutrophil, red cell distribution width, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) values in the febrile seizure group, while hemoglobin, hematocrit, mean corpuscular volume, lymphocytes, and mean platelet volume were significantly lower.
Conclusions: We think that in addition to markers such as WBC, leukocytes, and CRP for evaluating inflammation in patients with febrile seizures, simple, easily available, and inexpensive tests such as NLR and PLR can also be useful for assessing inflammation
Pregnancy Outcome in Women of Advanced Maternal Age: A Cross-Sectional Study in a Turkish Maternity Hospital
No full textBackground: There is a current trend towards delayed childbearing around the world. This is considered to increase the risk for poor maternal and neonatal outcomes. In this study, we evaluated pregnancy outcomes in women of advanced maternal age in a single maternity hospital in Turkey.Methods: Medical records of 517 women aged 35 years and older that gave birth between 2009 and 2010 were examined retrospectively. The chi-squared, Mann-Whitney U, and Student t tests were used for statistical analyses.Results: In total, 462 (89.3%) women aged 39 years or less and 55 (10.6%) women aged 40 years and older were included in the analysis. Cesarean sections, and neonatal mortality were more common in women of advanced maternal age (p = 0.004 and p=0.002, respectively). Neonatal mortality (OR: 0.1; 95% CI 0.02–1; p = 0.032), premature birth (OR: 0.4; 95% CI 0.2–0.8; p = 0.008), and low birth weight (LBW) (OR: 0.2; 95% CI 0.1–0.5; p < 0.001) were significantly higher in women 40 years and older. Respiratory distress syndrome (RDS) developed in 26% of babies with LBWs. All patients of neonatal death were diagnosed with asphyxiation or RDS.Conclusions: At the Bolu Izzet Baysal Maternity and Children’s Hospital, advanced maternal age was associated with increased adverse fetal and neonatal outcomes
Insulin Resistance and Other Comorbidities of Obesity as Independent Variables on Ventricular Repolarization in Children and Adolescents
No full textBackground: Obesity, a rapidly increasing global health problem in all age groups, is accepted as the basis for many chronic diseases through insulin resistance mechanism. This study aimed to examine whether insulin resistance and other comorbidities of obesity have an effect on the cardiac conduction system.
Methods: The study included 50 obese and 47 healthy individuals aged 6–18 years. ECGs of all cases were taken; ECG waves and intervals were measured manually.
Results: Of the obese group, 19 were boys (38%) and 31 were girls (62%), 27 were children (54%) and 23 were adolescents (46%), their ages were 11.3 ± 3.5 years. These particular characteristics were similar compared to the control group. However, in the obese group, the ECG parameters QTc (p = 0.001), QTd (p < 0.001), QTdc (p < 0.001), JTc (p < 0.001), Tp-e (p < 0.001), Tp-e/QT (p < 0.001), Tp-e/QTc (p < 0.001), Tp-e/JT (p < 0.001), and Tp-e/JTc (p < 0.001) were significantly longer. Twenty-five obese subjects (50%) had insulin resistance, when ECG parameters are compared to those without it, only JTc was significantly longer (332.3 ± 16.5 vs 321.7 ± 17.7 ms, p = 0.033). JTc duration mostly affected JT (p < 0.001) and QTc (p < 0.001). The 327 ms cut-off value of JTc indicated insulin resistance in the obese patients (p = 0.044) (sensitivity 60%, specificity 60%).
Conclusion: Insulin resistance and other comorbidities of obesity may cause ventricular repolarization abnormalities at an early age. JTc, an ECG parameter, can be a guide in assessing ventricular repolarization abnormality and the risk of arrhythmia in these patients.
Keywords: obesity, insulin resistance, comorbidities, ventricular repolarization, child, adolescenc
