323,142 research outputs found
Carbonic Anhydrase 9: mastering ferropoptosis resistance in cancer, protector or weak point?
No full textFerroptosis is a recently discovered form of iron-dependent programmed cell death, characterized by the toxic accumulation of lipid peroxides that disrupt cell membrane function. Cancer cells are particularly susceptible to ferroptosis due to their high iron requirements for growth and a metabolism that creates an intracellular environment conducive to triggering this death mechanism. However, cancer cells counteract this vulnerability through carbonic anhydrase 9 (CA9), a protein that regulates intracellular pH, ensuring conditions unfavorable for ferroptosis.\\nThis minireview explores the factors necessary to induce ferroptosis and examines how CA9 not only protects cancer cells but also facilitates their migration. The aim is to highlight potential therapeutic opportunities arising from disrupting the functionality of this protein
Orticaria pigmentosa e vitiligine : descrizione clinica e genetica di due casi familiari
No full text
Age/agite: the Artistic Re-elaboration of a Polyfunctional Interjection in Virgil’s Works
No full textIn this study, I try to establish the use and functions of the interjections age and agite in Virgil’s works, on the basis of ancient grammatical tradition and of the theory of pragmaticalization. In Virgilian poetry, age and agite can function as discourse and pragmatic markers. Moreover, age and agite create collocations with other elements. My focus is on some of these collocations, which are recurrent and appear with the same value in similar contexts. Both literary and non-literary and unofficial testimonia of Latin are consulted in order to determine where these collocations were in use and in what kind(s) of language. The data show that Virgil drew several collocations from the language of comedy and lively prose, drew one collocation from the learned poetry of Catullus, and invented some new ones. Therefore, his prevailing modus operandi consisted in re-elaborating well attested collocations in texts, which (artistically) reproduced colloquial Latin. This chapter offers an in-depth analysis of Virgil’s artistic re-elaboration of this colloquial material
Le funzioni dell'adiudicatio nell'actio communi dividundo
No full textLettura del libro di M. Beghini, dedicato alla funzione dell'adiudicatio nell'actio communi dividundo
Measuring Residual Stresses with Crack Compliance Methods: An Ill-Posed Inverse Problem with a Closed-Form Kernel
No full textBy means of relaxation methods, residual stresses can be obtained by introducing a progressive cut or a hole in a specimen and by measuring and elaborating the strains or displacements that are consequently produced. If the cut can be considered a controlled crack-like defect, by leveraging Bueckner’s superposition principle, the relaxed strains can be modeled through a weighted integral of the residual stress relieved by the cut. To evaluate residual stresses, an integral equation must be solved. From a practical point of view, the solution is usually based on a discretization technique that transforms the integral equation into a linear system of algebraic equations, whose solutions can be easily obtained, at least from a computational point of view. However, the linear system is often significantly ill-conditioned. In this paper, it is shown that its ill-conditioning is actually a consequence of a much deeper property of the underlying integral equation, which is reflected also in the discretized setting. In fact, the original problem is ill-posed. The ill-posedness is anything but a mathematical sophistry; indeed, it profoundly affects the properties of the discretized system too. In particular, it induces the so-called bias–variance tradeoff, a property that affects many experimental procedures, in which the analyst is forced to introduce some bias in order to obtain a solution that is not overwhelmed by measurement noise. In turn, unless it is backed up by sound and reasonable physical assumptions on some properties of the solution, the introduced bias is potentially infinite and impairs every uncertainty quantification technique. To support these topics, an illustrative numerical example using the crack compliance (also known as slitting) method is presented. The availability of the Linear Elastic Fracture Mechanics Weight Function for the problem allows for a completely analytical formulation of the original integral equation by which bias due to the numerical approximation of the physical model is prevented
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