12,244 research outputs found
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
Molecular mechanisms of phenotypic plasticity: Explorations of DNA methylation and transcriptional regulation using the honey bee
No full textHoney bee behavioral maturation exemplifies phenotypic plasticity, the ability of a single genotype to produce multiple phenotypes in response to environmental conditions (Scheiner, 1993; West-Eberhard, 1989). Behavioral maturation in honey bees is characterized by a socially regulated transition of adult worker bees from brood caring (“nursing”) to foraging outside hives (Winston, 1991). It involves a suite of behavioral and physiological changes regulated by multiple environmental and internal factors. With the sequenced honey bee genome (Honey Bee Genome Sequencing Consortium, 2006), and development of genomic techniques, honey bee behavioral maturation provides a platform to understand molecular mechanisms underlying phenotypic plasticity.
It has been demonstrated that phenotypic plasticity is associated with massive gene expression changes (Aubin-Horth & Renn, 2009). Therefore, it is essential to understand mechanisms of transcriptional regulation related to alternative phenotypes. This thesis focuses on two important aspects of transcriptional regulation: DNA methylation and transcription regulation by a nuclear receptor, Ultraspiracle (USP).
Chapter 2 presents results that demonstrate that there is a functional CpG methylation system in honey bees, the first well-characterized functional DNA methylation system in insects. Catalytically active orthologs of vertebrate DNA methyltransferase (Dnmts) were identified along with methylated genes. Compared to vertebrate genomes, DNA methylations in honey bees are sparse, and all of the identified methylations are intragenic, similar to results shown in other invertebrates. Differences in DNA methylation density and positions suggest possibly different functions of DNA methylation in vertebrates and invertebrates. The characterization of a DNA methylation system in honey bees paves the way to study its function in honey bee behavioral maturation. This paper was published in 2006 in Science 314: 645-647.
Chapter 3 presents a review of nutritional regulation of honey bee behavioral maturation and propose systems biology approaches to reveal the gene regulatory networks (GRNs) underlying behavioral maturation. It was published in 2010 in Wiley Interdisciplinary Reviews: Systems Biology and Medicine (published online in advance of print).
Chapter 4 presents results on transcriptional regulation related to behavioral maturation in the context of fat bodies gene expression change. As a first step, we focus on transcription regulation by USP, a nuclear receptor implicated in JH signaling. USP was first demonstrated to regulate behavioral maturation. usp knockdown in honey bee workers’ fat bodies significantly delayed onset of foraging. Genome-wide USP binding sites were then mapped in the fat bodies of nurses and foragers respectively. No difference of USP binding was detected, suggesting USP regulates gene expression depending on the availability of co-factors or ligands and chromatin environments. Functional analysis of USP putative genes reveals several genes involved in multiple signaling pathways in behavioral maturation, raising the possibility that USP works as a master regulator to integrate different signals during honey bee behavioral maturation.Item withdrawn by Mark Zulauf ([email protected]) on 2010-08-13T19:37:09Z
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Dissertations and Theses - Cell and Developmental Biology (ID: 702)
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Matt Christopher Papers - Accession 1309
No full textThe collection includes letters written by the children’s book author, Matt Christopher, to his son, Marty Christopher. Many of the letters also contain newspaper articles of interest to Matt Christopher, which deal with local sports teams, his writing career, his participation in an exhibition baseball game against the New York Giants in 1938, and other of general interest. Most of the letters are personal in nature, however, a majority of the letters delve into Matt Christopher’s writing career, personal interests, the author’s health, as well as his family life.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/2649/thumbnail.jp
Matt Christopher Papers - Accession 1221
No full textMatt Christopher (1917-1997) was a prolific author of children’s books having written over 100 books as well as over 300 short stories, articles, poems, and screenplays. Most of his writings dealt with sports themes, but he also wrote fantasy and mystery themed stories as well. The Matt Christopher Papers consist of both published and unpublished manuscripts, articles, and short stories. Also included are personal and business correspondence, biographical information, scrapbooks, photographs, and memorabilia.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1976/thumbnail.jp
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Repeated short-term exposure to diesel exhaust reduces honey bee colony fitness
No full textProduction of insect-pollinated crops is often reliant on honey bee (Apis mellifera) pollination services. Colonies can be managed and moved to meet the demands of modern intensified monoculture farming systems. Increased colony mortalities have been observed, which are thought be caused by interacting factors including exposure to pesticides, parasites, viruses, agricultural intensification, and changes in global and regional climate. However, whilst common tropospheric air pollutants (e.g. NOx, particulate matter etc) are known to cause a range of negative effects on human health, there is little evidence of their impact on the health of A. mellifera. This study investigates the effects of exposure to diesel exhaust on A. mellifera, both at the level of individual foragers and on the whole colony. We exposed a series of colonies to diesel exhaust fumes for two hours a day over the course of three weeks and contrasted their performance to a series of paired control colonies located at the same field site. We investigated markers of neuronal health in the brains of individual foragers and measured the prevalence of common viruses. Electronic counters monitored daily colony activity patterns and pollen samples from returning foragers were analysed to investigate plant species richness and diversity. The amounts of honey, brood and pollen in each colony were measured regularly. We demonstrated an upregulation of the synapse protein Neurexin 1 in forager brains repeatedly exposed to diesel exhaust. Furthermore, we found that colonies exposed to diesel exhaust lost colony weight after the exposure period until the end of the summer season, whereas control colonies gained weight towards the end of the season. Further investigations are required, but we hypothesise that such effects on both individual foragers and whole colony fitness parameters could ultimately contribute to winter losses of honey bee colonies, particularly in the presence of additional stressors
Dr. Christopher von Rueden – Faculty Author Interview
No full textDr. Christopher von Rueden, an anthropologist and Assistant Professor in the Jepson School of Leadership Studies, discusses a recent article entitled, “Men’s status and reproductive success in 33 non-industrial societies: Effects of subsistence, marriage system, and reproductive strategy,” which he co-authored with Dr. Adrian Jaeggi, an anthropologist at Emory University. Their findings were recently published in the journal, Proceedings of the National Academy of Sciences
ESP Across Cultures
No full textThis present volume constitutes the third online edition of ESP Across Cultures.
The decision to change from a paper-based to an online edition has undoubtedly
been beneficial in terms of enjoying greater visibility within the international academic
community. One thing that has not changed over the years, however, since
the inception of the journal in 2004, has been the policy of double-blind peer reviewing,
which means that only a selected number of the papers submitted end up as
being published.
There are seven papers in the current issue, each one analysing a particular aspect
of English for Specific Purposes from a cross-cultural perspective.
The first paper, by Hmoud S. Alotaibi, focuses on research article introductions
in Arabic, analysing the extent to which scholars writing in Arabic in the sphere of
education adhere to the CARS (Create A Research Space) model delineated by John
Swales which was elaborated in particular with regard to the academic conventions
widely adopted in the English-speaking world. Instead of restricting the investigation
to the introductory section as past studies in this field did, the author examines
all of the subheadings and he concludes that all introductions include Move 2 in a
subheading entitled the Problem of the Study, a result that contradicts previous
findings where the paucity of Move 2 was common in non-English RAs, and especially
in Arabic ones.
Patrizia Anesa analyses the websites of the main arbitration centres operating in
Asia from a textual perspective to define how they are discursively constructed and
can be used as promotional tools, thereby helping us to evaluate the importance assumed
by internationalization processes or by local cultural elements in promoting a
particular centre as a seat for international arbitration. She concludes that while
some scholars argue that we are witnessing the ‘Asianization’ of arbitration, with
the increasing bargaining power of Asian parties, on the other hand a phenomenon
of ‘Universal Arbitration’ is also emerging, i.e. a form of convergence of how disputes
are resolved so that parties of any nationality can operate in the same way
with ever fewer language barriers.
In their paper, Mahmood Reza Atai and Fatemeh Asadnia examine the communicative
and promotional function of university homepages by looking at the ‘university
overview’, ‘university mission statement’, and ‘university introduction at a
glance’ genres, using a corpus of 210 texts selected from homepages of the top 500
universities ranked by the Academic Ranking of World Universities. The findings
demonstrated that the three genres shared communicative purposes, functional
units, certain moves and steps, socio-academic contexts, and discourse community
members that led to the formation of a genre set.
Gaetano Falco explores ways of using comics in an MA course on translation of
economic texts as a means of stimulating the interest of language students with no
economics skills in order to introduce economics-related lexis and improve thematic
competence in general. He observes that empirical research has shown that films
and comics can indeed be useful resources to teach economic translation to students
with no skills in economics. However, the author warns that the use of comics for
educational purposes may have its drawbacks, e.g. when students deal with complex
sign systems which embody complex economic concepts, where often the humorous
element is lost.
In her paper, Irina Khoutyz describes the differences in how scholars present
their findings in research articles (RA) in international journals in English and in
Beyza Björkman
Christian Burgers
Jan Chovanec
Anda-Elena Cretiu
Erika Dalan
John Douthwaite
Hanem El-Farahaty
Said Faiq
Silvia Ferreri
Inmaculada Fortanet-Gómez
Pedro Fuertes-Olivera
Giuliana Garzone
Christoph Hafner
Ruba Khamam
Anna Loiacono
Geraldine Ludbrook
John McRae
Susan Petrilli
Silvia Pireddu
Tarja Salmi-Tolonen
Jeffrey Segrave
Charlotte Taylor
Margherita Ulrych
John Kenneth White
Jessica Williams
I hope you will enjoy the current issue of this journal and will make the most of
the free access to all past issues.
Christopher Williams
(Chief Editor)
6 FOREWORD
local journals in Russian. She then looks into the reasons for these differences, seeking
explanations from the sociocultural contexts in which these RAs were written,
as well as providing advice to local authors as to how to make their RAs more competitive
at the international level. The differences include the apparent lack of
structure of Russian RAs with respect to English RAs; the tendency in Russian authors
not to specify the purpose in writing a paper; and the tendency of Russian authors
to present the methodology used in less detail compared with English RAs.
Luisella Leonzini investigates the use of verbal and visual metaphors in economic-
media discourse within the context of the euro crisis by studying the correlation
between linguistic and pictorial metaphors and text-image intersemiotic relations.
The research is based on a cross-analysis of English and Italian editorial
articles published between 2009 and 2012. In both corpora, metaphorical realizations
frame the economic crisis which hit the single currency and the eurozone in
2009 as a partial collapse and hint at a possible return to stability in the form of a
recovery. The aim of this paper is to analyse the collapse/caduta and
recovery/ripresa metaphors across languages in the press.
Ian Robinson reports on using corpus linguistics to aid students in writing a creative
text. He looks at the available literature to help understand what is meant by
‘creativity’. A worksheet was prepared using a corpus linguistic analysis of modern,
English versions of the stories of the Brothers Grimm. This worksheet was constructed
with the use of a specialized corpus, and a stop-list was created which contained
single words as well as word clusters found in the tales. Students were then
asked to select some of these words and phrases to help them write stories which
were then analysed, and a follow-up questionnaire was used to elicit the students’
perceptions concerning creativity. The author concludes that creativity is essential
in EFL and that it is something to be fostered in students
Book review: The theatrical public sphere, by Christopher B. Balme
No full textBook review of: The theatrical public sphere, by Christopher B. Balme. Cambridge: Cambridge University Press, 2014; ISBN 9781107006836 (£60.00)Publisher PD
Famine men:
No full textA young man goes on a hunger strike to protest his father's obesity.M.A.by Christopher Gazzar
Skill is not enough: seeking connectedness and authority in mediation
No full textCoauthor Christopher Honeyman was struck by the flagging marketability of mainstream professionally trained mediators in the US. More and more parties were choosing retired judges and other practitioners who were not classically trained mediators to help them resolve their disputes. Searching for an explanation of this phenomenon, Honeyman found a possible answer in Melbourne, Australia, where he listened with a Western ear to the presentations of coauthors Loretta Kelly and Bee Chen Goh about the importance of connectedness and individual perceptions of authority to the parties in the mediation of Indigenous disputes. In this article, the authors present case histories from Australia and Malaysia to illustrate these concepts. They contend the same concepts are behind the shifting of the market for mediation in the United States
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