63,427 research outputs found
La “Prise en Charge" de un paciente bajo anticoagulantes o antiagregantes plaquetarios antes de una resección transuretral de próstata.
No full textFil: Becq-Kayal, M. C..
Anestesista Hospital Saint-Louis (Paris, Francia
Structured design based on the inversion factor parameter: Case study of ΔΣ modulator system
No full textThis paper presents the design flow from system-level specifications to transistor-level design for three different fully-differential amplifiers composing the first and the second integrator of a second-order hybrid multi-bit ΔΣ modulator. The circuit-level specifications for each amplifier are extracted using behavioral models and timedomain system-level simulations with a SNDR target value of 93 dB ± 2 dB. The amplifiers are designed using the structured analog design methodology consisting of circuit partitioning into basic analog blocks, specification derivation for each basic block, and transistor sizing in a specific design sequence. Transistor-level design is based on the choice of the inversion factor and the transistor length to achieve the required specifications of each block. After all three analog amplifiers are sized, the system-level performance is confirmed by time-domain simulations, and the obtained SNDR value is within the specified range. Copyright © 2007 by Department of Microelectronics & Computer Science, Technical University of Lodz.GR-KAEPFL, Electronics Labs., STI/IMM/LEG, CH-1015 Lausanne, Switzerland Marvell Switzerland Sarl, Route de Pallatex 17, CH-1163 Etoy, Switzerland, Export Date: 19 January 2010, Source: Scopus, Art. No.: 4286127, References: Enz, C., Krummenacher, F., Vittoz, E., An Analytical MOS Transistor Model Valid in All Regions of Operation and Dedicated to Low-Voltage and Low-Current Applications (1995) Analog Integrated Circuits and Signal Processing, pp. 83-114. , Kluwer Academic Publishers; Kayal, M., Randjelovic, Z., Auto-zero differential difference amplifier (2000) Electronics Letters, 36, pp. 695-696; Stefanovic, D., Krummenacher, F., Pastre, M., Kayal, M., BSIM2EKV: Un outil pour la conversion automatique des paramèters du modèle BSIM aux paramèteres du modèle EKV (2004) TAISA'04 5ème colloque sur le Traitement Analogique de l'Information, du Signal et ses Applications, pp. 85-88; Bult, K., Geelen, G., A fast-settling CMOS op amp for SC circuits with 90-dB DC gain (1990) IEEE Journal of Solid-State Circuits, 25, pp. 1379-1384; Stefanovic, D., Kayal, M., Pastre, M., Litovski, V., Procedural analog design (PAD) tool (2003) Fourth International Symposium on Quality Electronic Design, pp. 313-318; Stefanovic, D., Kayal, M., Pastre, M., PAD: A New Interactive Knowledge-Based Analog Design Approach (2005) Analog Integrated Circuits and Signal Processing Journal, 42, pp. 291-29
High-quality factor MEMS based oscillator: Silicon 9 MHz oscillator with low phase noise and high quality factor
No full textIn this paper, an oscillator based on a Vibrating Body Field Effect Transistor (VB-FET) working at 9.4MHz is presented. The electrical characteristics of this active MEM resonator are detailed for static and dynamic operation. The benefit of the intrinsic gain for oscillator design is analyzed and an oscillator design is proposed based on these findings. The reported oscillator performance shows the advantages of an active MEM resonator for the construction of MEM based oscillators with respect to the reduced requirements on the electronics. © 2009 by Department of Microelectronics & Computer Science.NANOLABGR-KAElectronic Laboratory, EPFL, 1015 Lausanne, Switzerland Nanoelectronic Devices Laboratory, EPFL, 1015 Lausanne, Switzerland, Export Date: 19 January 2010, Source: Scopus, Art. No.: 5289466, References: Nguyen, C.T.C., MEMS technology for timing and frequency control (2007) Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on, 54, pp. 251-270; Nathanson, J.H.C., Wickstrom, R.A., A resonant-gate silicon surface transistor with high-Q band-pass properties (1965) Applied Physics Letters, 7, pp. 84-86; Abele, N., Fritschi, R., Boucart, K., Casset, F., Ancey, P., Ionescu, A.M., Suspended-gate MOSFET: Bringing new MEMS functionality into solid-state MOS transistor (2005) Electron Devices Meeting, 2005. IEDM Technical Digest. IEEE International, pp. 479-481; Grogg, D., Mazza, M., Tsamados, D., Ionescu, A.M., Multi-gate Vibrating-body Field Effect Transistors (VB-FETs) (2008) Electron Devices Meeting, 2008. IEDM 2008. IEEE International, pp. 663-666; Nguyen, C.T.C., Howe, R.T., Design and performance of CMOS micromechanical resonator oscillators (1994) Frequency Control Symposium, 1994, pp. 127-134. , 48th, Proceedings of the 1994 IEEE International; Nguyen, C.T.C., Howe, R.T., An integrated CMOS micromechanical resonator high-Q oscillator (1999) Solid-state Circuits, IEEE Journal of, 34, pp. 440-455; Yu-Wei, L., Seungbae, L., Sheng-Shian, L., Yuan, X., Zeying, R., Nguyen, C.T.C., Series-resonant VHF micromechanical resonator reference oscillators (2004) Solid-state Circuits, IEEE Journal of, 39, pp. 2477-2491; Seungbae, L., Nguyen, C.T.C., Influence of automatic level control on micromechanical resonator oscillator phase noise (2003) Frequency Control Symposium and pda Exhibition Jointly with the 17th European Frequency and Time Forum, 2003, pp. 341-349. , proceedings of the 2003 ieee international; Grogg, D., Lo Conte, F., Kayal, M., Ionescu, A.M., 9 MHz vibrating body FET tuning fork oscillator (2009) EFTF-IFCS, , to be presented, Besançon; Grogg, D., Meinen, C., Tsamados, D., Tekin, H.C., Kayal, M., Ionescu, A.M., Double gate movable body micro-electro-mechanical FET as hysteretic switch: Application to data transmission systems (2008) Solid-state Device Research Conference, 2008. ESSDERC 2008. 38th European, pp. 302-305; Blagojevic, M., Pastre, M., Kayal, M., Fazan, P., Okhonin, S., Nagoga, M., Declercq, M., SOI capacitor-less 1-transistor DRAM sensing scheme with automatic reference generation (2004) IEEE Symposium on VLSI Circuits, pp. 182-183. , June; Blagojevic, M., Kayal, M., Pastre, M., Harik, L., Okhonin, S., Fazan, P., Capacitor-less 1T DRAM sensing scheme with automatic reference generation (2006) IEEE Journal of Solid-state Circuits (JSSC), 41, pp. 1463-1470. , June; Pastre, M., Kayal, M., Blanchard, H., A hall sensor analog front end for current measurement with continuous gain calibration (2007) IEEE Sensors Journal, 7 (5), pp. 860-867. , Special Edition on Intelligent Sensors, May; Kaajakari, V., Mattila, T., Oja, A., Seppa, H.A.S.H., Nonlinear limits for single-crystal silicon microresonators (2004) Microelectromechanical Systems, Journal of, 13, pp. 715-724; Kaajakari, V., Koskinen, J.K., Mattila, T., Phase noise in capacitively coupled micromechanical oscillators (2005) Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on, 52, pp. 2322-233
Substrate current modeling for high-voltage smart power BCD technology
No full textThis paper presents a compact- and a macro-model for estimating and simulating the perturbations induced in the substrate by high-voltage transistors switching inductive loads. On one hand, it allows the designer to predict the amount of switching noise generated by a particular topology. On the other hand, it enables a wise choice of the positioning of sensitive low-voltage circuits around the noisy devices, as well as the choice of appropriate shielding structures. The models proposed are validated by measurements on a prototype circuit at 25°C. © 2008 IEEE.GR-KALaboratoire d'Electronique Générale (LEG), Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Cited By (since 1996): 2, Export Date: 19 January 2010, Source: Scopus, Art. No.: 4606341, References: Murari, B., Bertotti, F., Vignola, G.A., (2002) Smart power ICs: Technologies and applications, , 2nd Edition, Springer, Berlin; Clement, F.J.R., Zysman, E., Kayal, M., Declercq, M., LAYIN: Toward a global solution for parasitic coupling modeling and visualization (1994) Custom Integrated Circuits Conference, pp. 537-540; Mitra, S., Rutenbar, R.A., Carley, L.R., Allstot, D.J., A methodology for rapid estimation of substrate-coupled switching noise (1995) Custom Integrated Circuits Conference, pp. 129-132; Schenkel, M., Pfàffli, P., Mettler, S., Reiner, W., Wilkening, W., Aemmer, D., Fichtner, W., Measurements and 3D Simulations of Full-Chip Potential Distribution at Parasitic Substrate Current Injection (2000) Solid-State Device Research Conference, pp. 600-603; Kayal, M., Saez, R.L., Pastre, M., The Reduction of switching noise using CMOS current steering logic (2003) Substrate Noise Coupling in Mixed-Signal ASICs, pp. 223-228. , Kluwe
Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells
No full textA number of genetic diseases, including cystic fibrosis, have been identified as disorders of protein trafficking associated with retention of mutant protein within the endoplasmic reticulum. In the presence of the benzo(c)quinolizinium drugs, MPB-07 and its congener MPB-91, we show the activation of cystic fibrosis transmembrane conductance regulator (CFTR) delF508 channels in IB3-1 human cells, which express endogenous levels of delF508-CFTR. These drugs were without effect on the Ca(2+)-activated Cl- transport, whereas the swelling-activated Cl- transport was found altered in MPB-treated cells. Immunoprecipitation and in vitro phosphorylation shows a 20% increase of the band C form of delF508 after MPB treatment. We then investigated the effect of these drugs on the extent of mislocalisation of delF508-CFTR in native airway cells from cystic fibrosis patients. We first showed that delF508 CFTR was characteristically restricted to an endoplasmic reticulum location in approximately 80% of untreated cells from CF patients homozygous for the delF508-CFTR mutation. By contrast, 60-70% of cells from non-CF patients showed wild-type CFTR in an apical location. MPB-07 treatment caused dramatic relocation of delF508-CFTR to the apical region such that the majority of delF508/delF508 CF cells showed a similar CFTR location to that of wild-type. MPB-07 had no apparent effect on the distribution of wild-type CFTR, the apical membrane protein CD59 or the ER membrane Ca(2+),Mg-ATPase. We also showed a similar pharmacological effect in nasal cells freshly isolated from a delF508/G551D CF patient. The results demonstrate selective redirection of a mutant membrane protein using cell-permeant small molecules of the benzo(c)quinolizinium family and provide a major advance towards development of a targetted drug treatment for cystic fibrosis and other disorders of protein trafficking
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
A low-power strategy for delta-sigma modulators
No full textThis paper presents a hybrid continuous-discrete-time Delta-Sigma modulator for portable communication systems following a low-power strategy. The proposed design methodology is extendable to different specifications. A multi-bit technique has been introduced in an efficient manner to optimize the power consumption, and an adaptive algorithm is used to allow for a 3-fold reduction in the number of comparators. Copyright © 2007 by Department of Microelectronics & Computer Science, Technical University of Lodz.GR-KAMarvell Semiconductor, Route de Pallatex 17, CH-1163 Etoy, Switzerland Electronics Laboratory (LEG), Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 11, CH-1015 Lausanne, Switzerland, Cited By (since 1996): 1, Export Date: 19 January 2010, Source: Scopus, Art. No.: 4286151, References: X. Lu, A novel signal-predicting multi-bit Delta-Sigma modulator, Proc. of the IEEE International Conference on Electronics Circuits and Systems, December 2004, pp. 105-108Zierhofer, C., Adaptive Sigma-Delta modulation with one-bit quantization (2000) IEEE Trans. on circuits and systems, pp. 408-415. , May; Dorrer, L., and al, A 3-mW74-dB SNR 2-MHz continuous-time Delta-Sigma ADC with a tracking ADC quantizer in 0.13-um CMOS (2002) IEEE J. of Solid-State Circuits, 37, pp. 1636-1644. , December; Fishov, A., Siracusa, E., Welz, J., Fogleman, E., Galton, I., Segmented mismatch-shaping D/A conversion (2002) Proc. Of the IEEE International Symposium on Circuits and Systems, 4, pp. 679-682. , May; Yan, S., Sanchez, S., A continuous-time Sigma-Delta modulator with 88-dB dynamic range and 1.1-MHz signal bandwidth (2004) IEEE J. of Solid-State Circuits, 39, pp. 75-86. , January; Kappes, M., A 2.2-mW CMOS band-pass continuous-time multi-bit Delta-Sigma ADC with 68dB of dynamic range and 1MHz bandwidth for wireless applications (2003) IEEE J. of Solid-State Circuits, 38, pp. 1098-1104. , July; Schreier, R., Lloyd, J., Singer, L., Paterson, D., Timko, M., Hensley, M., Patterson, G., Zhou, J., A 10-300-MHz IF-digitizing IC with 90-105-dB dynamic range and 15-33-kHz bandwidth (2003) IEEE J. of Solid-State Circuits, 38, pp. 1098-1104. , December; Nguyen, K., Adams, R., Sweetland, K., Chen, H., A 106-dB SNR hybrid Over-sampling analog-todigital converter for digital audio (2005) IEEE J. of Solid-State Circuits, 40, pp. 2408-2414. , December; Morrow, P., Chamarro, M., Lyden, C., Ventura, P., Abo, A., Matamura, A., Keane, M., Ryan, I., A 0.18um 102dB-SNR mixed CT SC audio-band Delta-Sigma ADC (2005) IEEE International Solid-State Circuit Conference, pp. 178-179; Haykin, S., van Veen, B., (1999) Signals and Systems, , John Wiley & Sons Inc, New-York; Pastre, M., Kayal, M., (2006) Methodology for the digital calibration of analog circuits and systems with case studies, , Springer, Berlin; Kayal, M., Pastre, M., Automatic Calibration of Hall Sensor Microsystems Microelectronics Journal; Pastre, M., Kayal, M., Blanchard, H., Continuously gain-calibrated Hall sensor analog front-end for current measurement International Solid-State Circuits Conference (ISSCC), February 6 to 10-San Francisco-US
Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel
No full textChloride channels play an important role in the physiology and pathophysiology of epithelia, but their pharmacology is still poorly developed. We have chemically synthesized a series of substituted benzo[c]quinolizinium (MPB) compounds. Among them, 6-hydroxy-7-chlorobenzo[c]quinolizinium (MPB-27) and 6-hydroxy-10-chlorobenzo[c]quinolizinium (MPB-07), which we show to be potent and selective activators of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. We examined the effect of MPB compounds on the activity of CFTR channels in a variety of established epithelial and nonepithelial cell systems. Using the iodide efflux technique, we show that MPB compounds activate CFTR chloride channels in Chinese hamster ovary (CHO) cells stably expressing CFTR but not in CHO cells lacking CFTR. Single and whole cell patch clamp recordings from CHO cells confirm that CFTR is the only channel activated by the drugs. Ussing chamber experiments reveal that the apical addition of MPB to human nasal epithelial cells produces a large increase of the short circuit current. This current can be totally inhibited by glibenclamide. Whole cell experiments performed on native respiratory cells isolated from wild type and CF null mice also show that MPB compounds specifically activate CFTR channels. The activation of CFTR by MPB compounds was glibenclamide-sensitive and 4, 4'-diisothiocyanostilbene-2,2'-disulfonic acid-insensitive. In the human tracheal gland cell line MM39, MPB drugs activate CFTR channels and stimulate the secretion of the antibacterial secretory leukoproteinase inhibitor. In submandibular acinar cells, MPB compounds slightly stimulate CFTR-mediated submandibular mucin secretion without changing intracellular cAMP and ATP levels. Similarly, in CHO cells MPB compounds have no effect on the intracellular levels of cAMP and ATP or on the activity of various protein phosphatases (PP1, PP2A, PP2C, or alkaline phosphatase). Our results provide evidence that substituted benzo[c]quinolizinium compounds are a novel family of activators of CFTR and of CFTR-mediated protein secretion and therefore represent a new tool to study CFTR-mediated chloride and secretory functions in epithelial tissues
Electrical model of a single pixel SOI phototransistor relying on the transient charge pumping technique
No full textIn this paper a floating body partially depleted SOI MOSFET used to measure light intensity using the transient charge pumping [1] is modeled through an equivalent electrical circuit. Essentially, photogenerated charges of the MOSFET are converted into a charge pumping frequency needed to maintain the drain current constant during the illumination. This contrasts with other conventional methods that rely on an accurate quantification of the drain current to measure the light intensity. Flux densities as low as 2mW/m2 were measured, thus confirming the potential of this approach. © 2007 IEEE.GR-KAEDLABIMM-STI- Electrical Department, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Export Date: 19 January 2010, Source: Scopus, Art. No.: 4388465, References: Okhonin, S., Nagoga, M., Fazan, P., Principles of transient charge pumping on partially depleted SOI MOSFETs (2002) IEEE Electron Device Letters, 23, pp. 279-281. , May; Gamal, A.E., Eltoukhy, H., An introduction to the technology, design and performance limits, presenting recent developments and future directions (2005) IEEE Circuits and Devices, , May-June; Yamamoto, H., Taniguchi, K., Hamaguchi, C., High-sensitivity SOI MOS photodetector with self-amplification (1996) Journal of Applied Physics, 35, pp. 1382-1386; Zhang, W., Chan, M., Ko, P.K., Performance of the floating gate/body tied NMOSFET photodetector on SOI substrate (2000) IEEE Transactions on Electron Devices, 47 (7), p. 1375. , July; Saliese, J.-M., Porret, A.-S., A novel approach to oharge-based non-quasi-static model of the MOS transistor valid in all modes of operation (2000) Solid-State Electronics, 44, pp. 887-894; L. Harik, J-M. Saliese and M. Kayal, Transient charge pumping as a new technique for a higher sensitivity SOI MOSFET photodetector to be published in ESSDERC September 2007Heremans, P., Witters, J., Groeseneken, G., Maes, H.E., Analysis of the charge pumping technique and its application for the evaluation of MOSFET degradation (1989) IEEE Transactions on Electron Devices, 36 (7), pp. 1318-1335. , Jul
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