1,722,291 research outputs found

    Nuclear medicine in chronic infections

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    Background. The availability of high sensitive radiopharmaceuticals for the diagnosis of an unknown focus of infection with whole body scanning and SPECT and the availability of high specific radiopharmaceuticals for the detection of a leucocytic infiltration are the basis of the high potential of nuclear medicine in patients with chronic infections. Both procedures are always complementary to radiological procedures,which can specify and better determine a detected focus and which can induce also infection imaging if the radiologic result is ambiguous. Radiopharmaceuticals. Not all available radiopharmaceuticals for the nuclear medicine imaging of infection and inflammation, i.e. Tc-99m-nanocolloids, Tc-99m-labelled human immunoglobulin, Tc-99m-HMPAO and In-111-oxin labelled leukocytes, Ga-67-citrate, Tc-99m-labelled antigranulocyte antibodies and their fragments and F-18-FGD-PET, are useful in all clinical situations, because there are differences in the availability, the radiation exposure, the costs and the underlying patho-physiological mechanism

    How will we teach and practice nuclear medicine in the next decade in Europe?

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    In the next decade, nuclear medicine physicians in Europe will try to guarantee a more homogeneous level of training and education of their specialty throughout the continent. In routine nuclear medicine, they will focus more on the possibilities and availability of positron-emission tomography (PET) and on nuclear medicine therapy. Nuclear medicine physicians will be more active and interactive with students at the universities and will offer more lectures and more active training in the specialty. Nuclear medicine specialists will try to be even more interactive with clinicians and make their specialty open and better understandable for other disciplines. Nuclear medicine physicians will initiate more cost-benefit studies and more multicenter studies to prove that their procedures are evidence-based. They will communicate more intensively with industry for a better understanding of clinical problems and for development of new useful radiopharmaceuticals. They will promote their specialty in the public more intensively and will reasonably explain the risks and benefits of radionuclide examinations. Copyright (C) 2000 by W.B. Saunders Company

    The EuroPsy Specialist Certificate in Work and Organizational Psychology

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    The paper describes the aims of EuroPsy (or European Certificate in Psychology) launched and managed by the European Federation of Psychologists’ Associations (EFPA) to provide a common standard of competence of professional training and academic education in psychology. The Specialist Certificate in Work and Organizational Psychology, developed by EAWOP, is an 'add-on’ to the Basic Certificate, and establishes the minimum requirements in terms of education, training and competences, developed by a practitioner after graduation and during his or her practice

    Nuclear medicine diagnostic modalities for skeletal system diseases

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    Eventhough new diagnostic methods,as CT/MRI, are widely available, the bone scintigraphy still does remain an important tool for imaging bone pathology. An increase in diagnostic accuracy is possible by using different imaging modalities: wholebody scan, threephase bone scintigraphy and SPECT. For this reason,the bone scintigraphy can be used for diagnosis of tumors/infections and therapy monitoring. Applying these methods, important informations can be gained for differential diagnosis. The bone scintigraphy is easy to perform,allows good whole-body overview by low radiation burden to the patient

    Patients with fever of unknown origin (FUO): diagnosis by nuclear medicine imaging

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    Fever of unknown origin (FUO) in immunocompetent and non neutropenic patients is defined os recurrent fever of 38,3 degrees C or greater, lasting 2-3 weeks or longer, and undiagnosed after 1 week of appropriate evaluation. The underlying diseases of FUO are numerous and infection accounts for only 20-40% of them. The majority of FUO-potients have autoimmunity and collagen vascular disease and neoplasm, which are responsible for about 50-60% of all cases. In this respect FOU in its classical definition is clearly separated from postoperative and neutropenic fever where inflammation and infection are more common. Although methods that use in-vitro or in-vivo labeled white blood cells (WBCs) have a high diagnostic accuracy in the detection and exclusion of granulocytic pathology, they are only of limited value in FUO-patients in establishing the final diagnosis due to the low prevalence of purulent processes in this collective. WBCs ore more suited in evaluation of the focus in occult sepsis. Ga-67 citrate is the only commercially available gamma emitter which images acute, chronic, granulomatous and autoimmune inflammation and also various malignant diseases. Therefore Ga-67 citrate is currently considered to be the tracer of choice in the diagnostic work-up of FUO. The number of Go-67-scans contributing to the final diagnosis was found to be higher outside Germany than it has been reported for labeled WBCs. F-18-2 ' -deoxy-2-fluoro-D-glucose (FDG) has been used extensively for tumor imaging with PET. Inflammatory processes accumulate the tracer by similar mechanisms. First results of FDG imaging demonstrated, that FDG may be superior to other nuclear medicine imaging modalities which may be explained by the preferable tracer kinetics of the small F-18-FDG molecule and by a better spatial resolution of coincidence imaging in comparison to a conventional gamma camera

    Patients with fever of unknown origin (FUO): diagnosis by nuclear medicine imaging

    No full text
    Fever of unknown origin (FUO) in immunocompetent and non neutropenic patients is defined os recurrent fever of 38,3 degrees C or greater, lasting 2-3 weeks or longer, and undiagnosed after 1 week of appropriate evaluation. The underlying diseases of FUO are numerous and infection accounts for only 20-40% of them. The majority of FUO-potients have autoimmunity and collagen vascular disease and neoplasm, which are responsible for about 50-60% of all cases. In this respect FOU in its classical definition is clearly separated from postoperative and neutropenic fever where inflammation and infection are more common. Although methods that use in-vitro or in-vivo labeled white blood cells (WBCs) have a high diagnostic accuracy in the detection and exclusion of granulocytic pathology, they are only of limited value in FUO-patients in establishing the final diagnosis due to the low prevalence of purulent processes in this collective. WBCs ore more suited in evaluation of the focus in occult sepsis. Ga-67 citrate is the only commercially available gamma emitter which images acute, chronic, granulomatous and autoimmune inflammation and also various malignant diseases. Therefore Ga-67 citrate is currently considered to be the tracer of choice in the diagnostic work-up of FUO. The number of Go-67-scans contributing to the final diagnosis was found to be higher outside Germany than it has been reported for labeled WBCs. F-18-2 ' -deoxy-2-fluoro-D-glucose (FDG) has been used extensively for tumor imaging with PET. Inflammatory processes accumulate the tracer by similar mechanisms. First results of FDG imaging demonstrated, that FDG may be superior to other nuclear medicine imaging modalities which may be explained by the preferable tracer kinetics of the small F-18-FDG molecule and by a better spatial resolution of coincidence imaging in comparison to a conventional gamma camera
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