4,797 research outputs found
How to Avoid Innovation Competence Loss in R&D Outsourcing
Full text linkCompanies developing complex products face a crucial dilemma: the benefits of research and development (R&D) outsourcing such as lower costs, access to specialist knowledge, or shorter development lead times often have negative consequences for competence development due to the loss of opportunities for learning by doing. Having experienced the problems of outsourcing R&D, Fiat developed a novel organizational solution that offers new insights as to how firms can organize R&D to protect against innovation competence loss in R&D outsourcing
Oskar Becker
No full textAnalisi dell'estetica di Oskare Becker e dei suoi legami con Schelling e Solger
Vegetation-environment relationships in a heavy metal-dry grassland complex
No full textHeavy-metal content is assumed to be the most important edaphic factor that determines vegetation composition on contaminated soil. We compared the effects of heavy metals on species composition and species richness in the heavy metal-dry grassland complex of the Bottendorf Hills (Central Germany) with those of other environmental factors. Based on 206 releves, we distinguished nine communities of the classes Koelerio-Corynephoretea and Festuco-Brometea. Four communities in which the metallophytes Armeria maritima subsp. halleri and Minuartia verna subsp. hercynica occurred with high frequency were classified as heavy metal subassociations of four different dry grassland associations because of the dominance of dry grassland species. We measured the soil content of copper, zinc and lead, and the carbonate content, C/N ratio, pH and conductivity of the soil, soil depth and incident radiation per site. The first axis resulting from a DCA was positively correlated with the cover and height of the herb layer, the soil depth and soil carbonate content, and negatively with the soil content of copper, the proportion of rocks, the soil C/N ratio and incident radiation per site. The number of vascular plants, bryophyte and lichen species per plot increased with pH up to 7.5 and then decreased slightly. Species richness increased with carbonate content and conductivity of the soil and decreased with the soil C/N ratio. Heavy metal content of the soil and species richness were not correlated. The occurrence of the metallophytes was strongly related to the copper content of the soil. In conclusion our study has shown that heavy metal content is not necessarily the main factor determining the total composition and richness of grasslands on soil containing heavy metals. Heavy metal grasslands are not necessarily floristically distinct from "normal" dry grasslands
The role of digital artefacts in early stages of distributed innovation processes
No full textThis paper offers insights on how digital artefacts foster coordination of individuals in distributed innovation projects by limiting the divergence of team members’ representations of the project. This role is particularly important when coordination mechanisms such as leadership and modularity show some limits. Using distributed innovation in open-source software as a setting, we develop and test the hypotheses that (1) the release of initial code in open-source software projects limits the divergence of team members’ representations and (2) limiting divergence of team members’ representations triggered by initial code release implies a higher probability of project survival, a non-trivial goal in such a setting. To test our hypotheses, we draw on a dataset of 5,703 open-source software projects registered on SourceForge.net. Both our hypotheses are supported, pointing towards fruitful directions for expanding research on the way distributed innovation processes are carried out when digital artefacts are involve
Innovation routines:Exploring the role of procedures and stable behaviour patterns in innovation
No full text
Innovation routines:Exploring the role of procedures and stable behaviour patterns in innovation
No full textSmall-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure
Full text linkAccumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar species remain unclear. Here, we show that αSyn can form in solution α-helical oligomers, which are off-pathway to fibrillization, through interaction with the tetrapyrrole phthalocyanine tetrasulfonate. Chemical cross-linking combined with mass spectrometry reveals a large number of intermolecular cross-links along the entire αSyn sequence in the phthalocyanine tetrasulfonate-stabilized αSyn oligomers. Our study suggests that stabilization of structured oligomers by small molecules provides a viable strategy to interfere with αSyn fibrillization.Fil: Fonseca Ornelas, Luis. Max Planck Institute for Biophysical Chemistry; AlemaniaFil: Schmidt, Carla. Martin Luther University Halle-Wittenberg; AlemaniaFil: Camacho Zarco, Aldo R.. German Center for Neurodegenerative Diseases ; AlemaniaFil: Fernandez, Claudio Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario. Universidad Nacional de Rosario. Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario; Argentina. Max Planck Institute for Biophysical Chemistry; AlemaniaFil: Becker, Stefan. Max Planck Institute for Biophysical Chemistry; AlemaniaFil: Zweckstetter, Markus. Max Planck Institute for Biophysical Chemistry; Alemania. German Center for Neurodegenerative Diseases ; Alemania. Universität Göttingen; Alemani
Mesh penetration of the sigmoid colon following a transabdominal preperitoneal hernia repair
No full textThe laparascopic transabdominal preperitoneal (TAPP) repair of an inguinal hernia is an established technique associated with notably low rates of recurrence and complication. Inguinal pain and anal bleeding following a TAPP procedure may result from the penetration of the repair mesh into the sigmoid colon. In this case report, we discuss this particular complication following the TAPP procedure. Subsequently, we describe the diagnostics as well as the surgical treatment necessary
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