140 research outputs found
A life threating happiness. A study of extreme sport enthusiasts' liaison with death: A study of extreme sport enthusiasts' liaison with death
No full textTitle: A life threating happiness – a study of extreme sport enthusiasts’ liaison with death Author: Troels Hedegaard KaltoftPublished: at Roskilde University, 2020Background: Each year extreme sport is fatal for several enthusiasts, despite this many continue to practice the branch of sport. In the western part of the world, there is an increased focus on safety why it is interesting that people on a voluntary basis chose to practice this risky sport.Purpose: The master thesis wishes to identify why these extreme sport enthusiasts willingly risk their life for a sport. This is done through an analysis where the enthusiasts respond to their own mortality and what is the driving factor of risking their life to their sport.Method: The underlying basis of the qualitative part is the conduct of everyday life. The empiric material is generated through semi structured interviews with five extreme sports enthusiasts.Conclusion: Extreme sport enthusiasts don’t practice their sport in order to risk their life, they engage because it allows them to experience places and happiness they can’t go without. Most have come to terms with the fact that the sport can be fatal and that they risk their life. They don’t desire the risk of losing their life, why they practice the sport as safe as possible. <br/
BoneBio: Breast cancer and bone biomarkers:Poster to abstract #24 BoneBio: The variable sensitivity of breast cancer patients to zoledronic acid
No full text#24 BoneBio: The variable sensitivity of breast cancer patients to zoledronic acid Presenting author: Anaïs Marie Julie Møller Presenting author's affiliation: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research, University of Southern Denmark Authors: Møller, A. M. J. (1), Bechmann, T. (2), Madsen, J. M. (3), Jakobsen E. H. (2), Søe K. (4) Affiliations: 1: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research,University of Southern Denmark 2: Department of Oncology, Vejle Hospital; Department of Oncology, Hospital of South West Jutland 3: Department of Clinical Immunology and Biochemistry, Vejle Hospital 4: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research, University of Southern Denmark; OPEN – Open patient data Explorative Network Abstract: Introduction Breast cancer (BC) is the most prevalent cancer among women in Denmark. BC cells frequently metastasize to bone tissue, where they initiate a “vicious cycle” involving the bone resorbing osteoclasts. This results in local bone loss, increased fracture risk, resistance of cancer cells, a reduced quality of life, and survival. Questions Can bone biomarkers (CTX: degradation, PINP: formation) be used for diagnosis and monitoring? Can it detect those patients that are least sensitive to zoledronic acid? Materials and methods 50 BC patients with newly diagnosed bone metastases (80 years or younger). Primary variables: absolute and delta‐values of CTX and PINP, progression of bone disease, and death. Preliminary results Start of recruitment: May 2016 ‐ status: 49/50 pts. After 3 months of treatment with zoledronic acid the median CTX levels are decreased by 69% from baseline (p<0.0001) while median PINP levels are decreased by 62% (p=0.0008). But the percent change from baseline after 3 months of treatment varies from +170% to ‐90% for CTX and from +300% to ‐92% for PINP, indicating large variations in sensitivity to zoledronic acid among patients. In addition, our results indicate that the 9 patients that have died so far were all amongst the less sensitive. Finally, patients with clinical signs of progression in bone disease show elevated marker levels several months in advance. Conclusions Bone biomarkers CTX and PINP seem promising as a complementary tool for diagnosis and monitoring of BC patients with bone metastases. The trial is still ongoing and the last patient is expected to leave the trial in 1 to 3 years. We hope to determine thresholds for PINP and CTX that can be used to detect relapse in bone disease earlier than today. A future routine use of these markers may lead to new individualized treatment strategies improving quality of life and possibly survival
BoneBio: Breast cancer and bone biomarkers:Poster to abstract #24 BoneBio: The variable sensitivity of breast cancer patients to zoledronic acid
No full text#24 BoneBio: The variable sensitivity of breast cancer patients to zoledronic acid Presenting author: Anaïs Marie Julie Møller Presenting author's affiliation: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research, University of Southern Denmark Authors: Møller, A. M. J. (1), Bechmann, T. (2), Madsen, J. M. (3), Jakobsen E. H. (2), Søe K. (4) Affiliations: 1: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research,University of Southern Denmark 2: Department of Oncology, Vejle Hospital; Department of Oncology, Hospital of South West Jutland 3: Department of Clinical Immunology and Biochemistry, Vejle Hospital 4: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research, University of Southern Denmark; OPEN – Open patient data Explorative Network Abstract: Introduction Breast cancer (BC) is the most prevalent cancer among women in Denmark. BC cells frequently metastasize to bone tissue, where they initiate a “vicious cycle” involving the bone resorbing osteoclasts. This results in local bone loss, increased fracture risk, resistance of cancer cells, a reduced quality of life, and survival. Questions Can bone biomarkers (CTX: degradation, PINP: formation) be used for diagnosis and monitoring? Can it detect those patients that are least sensitive to zoledronic acid? Materials and methods 50 BC patients with newly diagnosed bone metastases (80 years or younger). Primary variables: absolute and delta‐values of CTX and PINP, progression of bone disease, and death. Preliminary results Start of recruitment: May 2016 ‐ status: 49/50 pts. After 3 months of treatment with zoledronic acid the median CTX levels are decreased by 69% from baseline (p<0.0001) while median PINP levels are decreased by 62% (p=0.0008). But the percent change from baseline after 3 months of treatment varies from +170% to ‐90% for CTX and from +300% to ‐92% for PINP, indicating large variations in sensitivity to zoledronic acid among patients. In addition, our results indicate that the 9 patients that have died so far were all amongst the less sensitive. Finally, patients with clinical signs of progression in bone disease show elevated marker levels several months in advance. Conclusions Bone biomarkers CTX and PINP seem promising as a complementary tool for diagnosis and monitoring of BC patients with bone metastases. The trial is still ongoing and the last patient is expected to leave the trial in 1 to 3 years. We hope to determine thresholds for PINP and CTX that can be used to detect relapse in bone disease earlier than today. A future routine use of these markers may lead to new individualized treatment strategies improving quality of life and possibly survival
BoneBio: Breast cancer and bone biomarkers:Poster to abstract #24 BoneBio: The variable sensitivity of breast cancer patients to zoledronic acid
No full text#24 BoneBio: The variable sensitivity of breast cancer patients to zoledronic acid Presenting author: Anaïs Marie Julie Møller Presenting author's affiliation: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research, University of Southern Denmark Authors: Møller, A. M. J. (1), Bechmann, T. (2), Madsen, J. M. (3), Jakobsen E. H. (2), Søe K. (4) Affiliations: 1: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research,University of Southern Denmark 2: Department of Oncology, Vejle Hospital; Department of Oncology, Hospital of South West Jutland 3: Department of Clinical Immunology and Biochemistry, Vejle Hospital 4: Clinical Cell Biology, Department of Pathology, Odense University Hospital; Department of Clinical Research, University of Southern Denmark; OPEN – Open patient data Explorative Network Abstract: Introduction Breast cancer (BC) is the most prevalent cancer among women in Denmark. BC cells frequently metastasize to bone tissue, where they initiate a “vicious cycle” involving the bone resorbing osteoclasts. This results in local bone loss, increased fracture risk, resistance of cancer cells, a reduced quality of life, and survival. Questions Can bone biomarkers (CTX: degradation, PINP: formation) be used for diagnosis and monitoring? Can it detect those patients that are least sensitive to zoledronic acid? Materials and methods 50 BC patients with newly diagnosed bone metastases (80 years or younger). Primary variables: absolute and delta‐values of CTX and PINP, progression of bone disease, and death. Preliminary results Start of recruitment: May 2016 ‐ status: 49/50 pts. After 3 months of treatment with zoledronic acid the median CTX levels are decreased by 69% from baseline (p<0.0001) while median PINP levels are decreased by 62% (p=0.0008). But the percent change from baseline after 3 months of treatment varies from +170% to ‐90% for CTX and from +300% to ‐92% for PINP, indicating large variations in sensitivity to zoledronic acid among patients. In addition, our results indicate that the 9 patients that have died so far were all amongst the less sensitive. Finally, patients with clinical signs of progression in bone disease show elevated marker levels several months in advance. Conclusions Bone biomarkers CTX and PINP seem promising as a complementary tool for diagnosis and monitoring of BC patients with bone metastases. The trial is still ongoing and the last patient is expected to leave the trial in 1 to 3 years. We hope to determine thresholds for PINP and CTX that can be used to detect relapse in bone disease earlier than today. A future routine use of these markers may lead to new individualized treatment strategies improving quality of life and possibly survival
Are patient-reported outcomes useful in post-treatment follow-up care for women with early breast cancer? A scoping review
No full textCathrine Lundgaard Riis,1–3 Troels Bechmann,1,2 Pernille Tine Jensen,4,5 Angela Coulter,2,3,6 Karina Dahl Steffensen1–3 1Department of Oncology, Vejle Hospital, Vejle, Denmark; 2Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; 3Center for Shared Decision Making, Vejle, Denmark; 4Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark; 5Department of Clinical Research, University of Southern Denmark, Odense, Denmark; 6Nuffield Department of Population Health, University of Oxford, Oxford, UK Background: Patient-reported outcomes (PROs) are frequently used to evaluate treatment effects and quality of life in clinical trials. The application of PROs in breast cancer clinics is evolving but their use to generate real-time information for use in follow-up care is uncommon. This proactive use might help to shift healthcare delivery toward a more patient-centered approach by acting as a screening tool for unmet needs or a dialogue tool to discuss issues proposed by the patient.Aims: This review aims to determine the effects and feasibility of using PROs proactively during follow-up care in early breast cancer.Materials and methods: A systematic search was conducted in January 2019 in PubMed, Cochrane Library, Embase, and CINAHL. Studies that exclusively concerned women treated for early breast cancer where PROs were used as a proactive tool during follow-up were included.Results: The search revealed a total of 653 records and four eligible studies were identified; three of which concerned the use of PROs both as a screening tool and as a dialogue tool, and one study in which PROs were used solely as a screening tool. The studies explored the feasibility of collecting and integrating PROs in the clinic and their ability to detect otherwise unrecognized problems. All of the included studies were prone to bias, but they point to potential benefits in respect of better symptom management in follow-up care.Conclusion: Our search identified a small number of low to moderate quality studies of the proactive use of PROs during follow-up after treatment for early stage breast cancer. The limited evidence available suggests that PROs may be useful for providing a more complete picture of the patient’s symptoms and problems, possibly leading to improvements in symptom management. Keywords: proactive, patient-reported outcome, PRO, breast cancer, follow-u
impact of beach states on alongshore transport
No full textImpact of spatial variability in the nearshore bathymetry on net sediment transport rates has been investigated for a selection of observed beach states at the Dutch coast. The beach states comprise a longshore bar trough and two transverse bar rip situations, which were present at the large scale Sand Motor nourishment at the Holland coast. These observed bathymetric features were then applied multiple times next to each other along a longer stretch of coast to obtain a repeating pattern of the considered beach state. The wave transformation towards the shore, alongshore wave-driven and water-level setup driven currents and sediment transport were computed with the Delft3D model, which has been applied successfully for many other studies at the Sand Motor. It was found that net sediment transport is considerably influenced for the most pronounced transverse bar rip configuration, which was most prominent for conditions with small wave angles (i.e. less than 10° from shore-normal). Furthermore, a decrease in transport rates is found for conditions from larger angles of wave incidence (i.e. 30 to 45° from shore-normal). Impacts of the bathymetries of longshore bar trough and the less pronounced transverse bar rip system on net sediment transport rates were much smaller. The actual cause for the enhancement (or decrease) of the net transport for the transverse bar rip configuration is expected to be related to 1) the oblique orientation of the rip-channel for the considered configuration as well as to 2) a more diffusive pattern of the wave breaking as a result of the refraction on the spatially variable bathymetry.Coastal Engineerin
Evolution of alongshore bathymetric variability around a mega-scale beach nourishment
No full textThe presence of complex nearshore sand bar patterns (i.e. alongshore bathymetric variability) has an impact on local currents, affecting recreational safety and nearshore mixing processes. This study assesses the evolution of alongshore bathymetric variability along the Delfland coast in The Netherlands, over the first 5 years after construction of a mega-scale beach nourishment (the Sand Motor) in the central part of the coastal cell. A total of 38 bathymetric surveys was conducted over this period. Alongshore variability was quantified by subtracting an alongshore averaged bathymetry from the actual surveyed bed levels for both the intertidal and subtidal zone. From 2 years after construction onwards, the subtidal nearshore bathymetry at the Sand Motor is considerably more alongshore variable than the adjacent parts of the Delfland coast. Intertidal variability tends to be high in areas where beach groynes are present.Coastal EngineeringEnvironmental Fluid Mechanic
Connecting subtidal and subaerial sand transport pathways in the Texel inlet system
No full textPotential transport pathways between the subtidal and subaerial part of tidal inlet systems are explored by means of a case study of Texel Inlet, The Netherlands. Based on a morphologic analysis of multi-annual, high-resolution bathymetric and topographic data sets we hypothesize that two mechanisms connect the subtidal and subaerial parts of the system. The first mechanism relates to deposition on the tip of the island occurring to a large extent below spring high tide level, providing a fresh sediment source available for aeolian transport during parts of the tidal cycle. The second mechanism relates to sand deposition on the wide sandflat above spring high tide level occurring during storm surge flooding. These deposits are then available for aeolian transport during regular water levels. Due to the dominant wind direction at Texel Island, this leads to extensive dune formation on the downwind end of the sandflat.Policy AnalysisCoastal Engineerin
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