11 research outputs found
Data Supplement from Cell and Molecular Determinants of <i>In Vivo</i> Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
No full textSupplementary Figures S2-S5. Responses of the remaining MLL-ALL xenografts not shown in Figure 2; S3. Responses of the remaining BCP-ALL xenografts not shown in Figure 2; S4. Responses of the remaining T-ALL xenografts not shown in Figure 2; S5. Correlation of xenograft in vivo responses to single agent ABT-263 with an induction-type combination regimen of vincristine, dexamethasone and L-asparaginase (VXL)</p
Data Supplement from Cell and Molecular Determinants of <i>In Vivo</i> Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
No full textSupplementary Figures S14-S15. In vivo efficacy of ABT-263 in combination with established drugs against ALL-2, ALL-19 and ALL-31; S15. MCL1 protein expression at different stages of spleen extraction</p
Data Supplement from Cell and Molecular Determinants of <i>In Vivo</i> Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
No full textSupplementary Tables S1-S4. Summary of the Objective Response Measure (ORM) scoring method; S2. Details of known chromosomal translocations in the xenograft panel; S3. Top 100 discriminating genes for each xenograft subtype identified by microarray analysis of gene expression; S4. Gene Set Enrichment Analysis (GSEA) of subtype specific genes</p
Data Supplement from Cell and Molecular Determinants of <i>In Vivo</i> Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
No full textSupplementary Figures S6-S9. Correlations between BCL2 family gene expression and in vivo ABT-263 sensitivity in the MLL-ALL xenograft panel; S7. Correlations between BCL2 family gene expression and in vivo ABT-263 sensitivity in the BCP-ALL xenograft panel; S8. Correlations between BCL2 family gene expression and in vivo ABT-263 sensitivity in the T-ALL xenograft panel; S9. Representative immunoblot of MCL1 protein expression in ALL xenografts.</p
Data Supplement from Cell and Molecular Determinants of <i>In Vivo</i> Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
No full textSupplementary Tables S5-S8. Complete summary of in vivo single-agent ABT-263 responses of individual mice; S7. In vivo efficacy of combining ABT-263 with vincristine (VCR), dexamethasone (DEX) or L-asparaginase (L-ASN) against pediatric ALL Xenografts; S8. Complete summary of in vivo responses of ABT-263 combined with vincristine (VCR), dexamethasone (DEX) or L-asparaginase (L-ASN) of individual mice</p
Data Supplement from Cell and Molecular Determinants of <i>In Vivo</i> Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
No full textSupplementary Figure S1. Examples of flow cytometry data analysis for in vitro cytotoxicity co-culture assay.</p
Data Supplement from Cell and Molecular Determinants of <i>In Vivo</i> Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
No full textSupplementary Methods for Suryani Carol et al</p
Data Supplement from Cell and Molecular Determinants of <i>In Vivo</i> Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
No full textSupplementary Figures S10-S13. In vitro xenograft responses to ABT-263 by co-culture assay; S11. Formulae to determine assay sensitivity and specificity; S12. Live and dead cell analysis of each xenograft sample using 7-AAD staining and flow cytometry; S13. Comparison of ABT-263 responses for 5 xenograft samples in co-culture system versus single-cell suspension</p
Supplementary Table 1 from USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia
No full textSupplementary Table 1</p
Figures S1-17 plus legends from USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia
No full textSupplementary Figs. 1-17 with legends</p
