8 research outputs found
Repellent Activity of Extracts of Black Pepper, Black Seeds, Garlic and White Cumin Against Red Flour Beetle
No full textMany insects are pests of standing crops and stored grains that cause lot of damage and economic losses every year. Commonly these are controlled by synthetic compounds that are unsafe for humans and environment. Certain parts of plants are used for their repellent activity against insect pests of stored grains. In this context, the present study was planned to investigate the repellent activity of extracts of black pepper, black seeds, garlic and white cumin against red flour beetle that cause a huge damage to stored food crops. Repellent activity was tested using multiple concentrations of these extracts. Results of the present study concluded that 2 plant extracts have shown effective repellent activity against red flour beetle. The most effective extract was garlic followed by black pepper in various concentrations. Both were more effective at 1.5 % concentration. It is concluded in this study that these plants are natural sources of repellent compounds and hence are a potential source of biological insect repellents
What it is and Where I am: Spatial Orientation and Navigation Strategies among Visually Impaired People in Pakistan
No full textThe study explored spatial reference frames and navigation strategies among visually impaired people. The study focuses on the different kinds of reference frames that participants\u27 verbalised responses hint at. Through the Cognitive Discourse Analysis methodological framework (Tenbrink, 2015), we designed route description and navigation guidance tasks to collect a large set of linguistic data from 19 participants – 38 discourses. Tenbrink and Kuhn’s (2011) framework of spatial reference frames is employed to find out the nature of reference frames employed by participants during navigation tasks and to identify navigation strategies of visually impaired people. The types of reference frames identified are static external intrinsic reference frames, static external relative reference frames, static internal intrinsic reference frames and static internal relative reference frames. The findings of the study suggest better ways for the training of visually impaired people especially in the institutes of people with special needs
Human papillomavirus infection in females with normal cervical cytology: Genotyping and phylogenetic analysis among women in Punjab, Pakistan
No full textBackground: Globally, cervical cancer is the fourth most common cancer in women and the seventh most common cancer overall, accounting for an estimated 300 000 annual deaths. Human papillomavirus (HPV) is the second most common cause of cervical cancer worldwide. HPV screening is not a common practice in Pakistan. The aim of this study was to determine the prevalence of HPV and HPV types in women with a normal cytology of the cervix living in the upper and lower regions of Punjab, Pakistan, and to analyze the risk factors for HPV in this region.
Methods: PCR analysis was performed for 1011 female patients with a normal cytology of the cervix from various districts of Punjab Province, Pakistan. Risk factors for the acquisition of HPV were studied. High-risk HPV types (HPV16 and HPV18) were detected using the Abbott Real Time HR HPV test. To determine the genotype, partial L1 region sequences of HPV-positive samples were subjected to sequencing using MY/09/MY11 primers, and a phylogenetic tree was constructed using CLC software.
Results: The study found a 4.74% prevalence of HPV, with the most frequent HPV type found being the low-risk HPV6 (in 25% of infected individuals), followed by HPV55 (22.9%), HPV11 (20.8%), and high-risk types HPV45 (12.5%), HPV33 (8.33%), HPV18 (6.25%), and HPV16 (4.16%). Phylogenetic analysis of all HPV types in this study showed 80–99% nucleotide identity with types related to the same species. The sequences were clustered with China, India, Mexico, Iran, Slovenia, and Germany, showing the diversity in origin of the various genotypes prevalent in Pakistan.
Conclusions: In this population with a normal cervical cytology, the prevalence of high-risk HPV types was very low. The major prevalent HPV genotype in Punjab Province of Pakistan was the low-risk HPV type 6, followed by HPV type 55. Sequencing of the partial L1 region suggested that the region was highly conserved in all reported sequences. This study highlights the need to conduct robust epidemiological studies in the region and to develop regular HPV screening so that the situation does not reach an alarming stage resulting in cervical cancer
Human papillomavirus infection in females with normal cervical cytology: Genotyping and phylogenetic analysis among women in Punjab, Pakistan
No full textBiochemical Markers of Liver Toxicity among Coal Mine Workers of Punjab, Pakistan Suffering from HCV
No full textHepatitis C is among the leading hepatic disorders in current period through which about 3 % world population has been anguish among them 170 million were diagnosed as persistent carriers. A great range of alteration in liver biochemical parameters were found to be allied with HCV infestation. Current study was designed to evaluate the extent of HCV mediated abnormalities in liver biochemical markers which includes ALT (alanine aminotransferase), AST (Aspartate transaminase), ALP (Alkaline Phosphatase) and serum bilirubin. The study was conducted on coal miners of Punjab province, Pakistan. HCV was primarily diagnosed through one step rapid test device after which positive samples were confirmed through ELISA. Biochemical markers were determined through Autoanalyzer by using standard procedure provided with spinreact kits. Simple linear regression analysis significantly explained 24 %, 56.2 %, 68.8 % and 56 % variance in ALT (alanine aminotransferase), AST (Aspartate transaminase), ALP (Alkaline Phosphatase) and serum bilirubin level among HCV positive coal mine workers respectively. Results have clearly indicated significant correlation between HCV seropositivity and liver biochemical markers. Findings of present study conclude monitoring of liver biochemical markers is crucial during HCV infectivity as it represents the degree of impairment in liver functioning. In addition to this elevation in these diagnostic markers could points toward the presence of HCV in respective individual
Analysing the Impact of Education Policies and Their Implementation on the School Education System in Punjab, Pakistan
No full textIn Punjab, Pakistan, a province whose educational outcomes are pivotal to national development, the school system continues to struggle with significant challenges in access, quality, and equity. Despite a long history of ambitious education policies, a persistent and critical gap exists between policy intentions and their practical implementation, leaving many students without quality learning opportunities and teachers without adequate support. This narrative review analyzes the landscape of education policy and reform since 2001, synthesizing a wide body of evidence from policy documents, peer-reviewed academic research, and government reports to diagnose the root causes of this systemic implementation failure. The findings reveal several interconnected bottlenecks that consistently stall improvement. Chronic policy inconsistency, driven by volatile political cycles, prevents long-term strategies from taking root. Weak monitoring and evaluation systems render it nearly impossible to track progress or make evidence-based adjustments, while deep-seated urban-rural disparities in funding and resources perpetuate cycles of inequality. These issues are compounded by systemic corruption and administrative inefficiency that divert critical funds and erode public trust. Crucially, the review highlights a pervasive lack of meaningful stakeholder engagement in the policy process, which undermines local ownership and the sustainability of reforms. The paper argues that breaking this cycle requires a fundamental shift away from top-down reforms towards more adaptive and participatory strategies. This involves a concerted effort to strengthen policy coherence, invest in teacher capacity through continuous professional development, leverage technology for transparency, and empower communities through participatory monitoring to finally bridge the policy-practice gap.
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Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial.
No full textBACKGROUND: Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. METHODS: In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. FINDINGS: Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65-1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52-0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88-1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. INTERPRETATION: Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. FUNDING: London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation
