54 research outputs found
Don't give up what's yours, Africville speaker warns
No full textNewspaper articleThe author reports on the fifth annual reunion of former Africville residents
Seaview Park road meeting waste of time-O'Malley
No full textNewspaper articleThis brief article airs Deputy Mayor Marie O’Malley’s frustration with Halifax Council’s reticence to hold a public meeting on the proposed route through Seaview Park. It also outlines the reasons for Ms. O’Malley’s dissatisfaction with Ward 2 Councilman Walter Fitzgerald’s suggestion that the city hold a public information session on the same matter instead
Mathematics in a fun and playful way : A video –observation study of children`s play in preschool
No full textAbstract Swedish title; Matematik på ett lekfullt sätt – En videoobservationsstudie av barns lek i förskolan. English title; Mathematics in a fun and playful way. A video –observation study of children`s play in preschool Author; Barbra Aparo Language; Swedish with an English summary. Supervisor; Gabriella Gejard Examiner; Pia Maria Ivarsson Term; Spring 2017 The purpose of this study is to discover what types of mathematical activities that can arise from children`s free play. The study focuses on children between the ages of 3 and 6 years. In this paper, i explore how children through play engage in different mathematical activities. The research questions are; In what kind of situations do children use mathematical concepts? How can the mathematics that arise in children`s play be categorized? The study is based on Alan Bishops six cultural and historic mathematical activities and variations theory. Alan Bishops mathematical activities were used to analyse and categorise the different types of mathematics that children engage in during their free play. Variations theory was used as a method to describe how children learn those mathematical activities that arise in their play and what they need in order for learning to occur. Data were collected through qualitative methods and the primary data source for the study were video recordings. Results show that all the Alan Bishops mathematical activities arise in children`s free play. These activities are; counting, locating, measuring, designing, playing and explaining. The results also show that children in their free play explore patterns and shape, compare sizes, measurement, weight and volume, develop problem-solving, count things, group, sort, categorize and classify various objects. Results also show how children in various play situations used mathematical concepts like large –small, heavy –light, long –short, same –different, more –less etc. Keywords: Free play, play, mathematics, variation theory, children, mathematical activities, preschool Sammanfattning Syftet med studien är att genom observationer undersöka om och i så fall vilken matematik som förekommer i barns fria lek. Jag har undersökt och observerat hur barn genom lek engagerar sig i olika matematiska aktiviteter. Denna uppsats är begränsad till att endast undersöka barn mellan 3 och 6 år. Jag använder mig av följande frågeställningar; I vilka situationer/lekar använder sig barnen av matematiska begrepp? Hur kan matematiken som förekommer i barnens lekar kategoriseras? De teoretiska utgångspunkterna är Alan Bishops sex kulturella och historiska matematiska aktiviteter och variationsteori. Bishops sex matematiska aktiviteter har jag valt för att analysera och kategorisera de olika matematiska aktiviteter som förekommer i barns fria lek. Jag har använt mig av variationsteori som ett verktyg för att beskriva hur barn lär matematik i leken, och vad de behöver för att kunna lära sig. I studien har jag använt mig av en kvalitativ metod i form av videoobservationer. Resultatet visar att alla Bishops matematiska aktiviteter förekommer i barns fria lek. Dessa kategorier är räkna, mäta, lokalisera, förklara, konstruera/designa och leka. Resultatet visar även att barn i den fria leken får möjlighet att utforska mönster och former, storlek, volym, mäta, räkna, utveckla problemlösning, sortera och kategorisera mängder av olika föremål. Resultatet visar också att barn i olika leksituationer bekantar sig med begreppen lika –olika, lång –kort, smal –bred, hög –låg, och så vidare. Nyckelord: Fri lek, lek, matematik, matematiska aktiviteter, variationsteori, barn, förskola
Charles Barbra : «Esquisse de la vie d\u27un vitruose»（II） (traduction japonaise avec notes et présentation)
No full textCharles Barbra : «Esquisse de la vie d\u27un vitruose»（Ⅰ） (traduction japonaise avec notes et présentation)
No full textAbstract 3751: Allogeneic EGFRvIII chimeric antigen receptor T cells for treatment of glioblastoma
No full textAbstract
Glioblastoma multiforme (GBM) is a highly aggressive form of brain tumors with a 5-year survival rate of less than 10%. Standard-of-care combining radiation therapy with temozolomide only yields a median survival of 14.6 months and more effective therapeutic options to extend patient lives are urgently needed. EGFR variant III (EGFRvIII) is a tumor specific mutant of EGFR found in 25-30% of GBM but not expressed in healthy tissues. EGFRvIII is formed by an in-frame deletion of exons 2-7 of the wild-type EGFR which leads to removal of 267 amino acids in the extracellular domain of the receptor. The truncated receptor loses its ability to bind ligands but acquires constitutive kinase activity. The lack of normal tissue expression makes EGFRvIII an ideal target for developing CAR T therapy. Most CAR T therapies in clinical development use the patients’ own T cells for CAR T manufacturing. Our approach is to develop an “off-the-shelf” CAR-T treatment for GBM using healthy donor T cells with the TCR (T-cell receptor) disrupted to prevent graft-versus-host disease. This allogeneic approach could circumvent challenges faced by some patients due to limited availability and quality of their own T cells and rapid progress of their diseases, and has the potential to reduce the high cost associated with autologous CART therapy. Using phage panning and hybridoma approaches, we generated a series of humanized and fully human EGFRvIII antibodies with a wide range of affinities. Recombinant EGFRvIII protein binding by Biacore and FACS assays using EGFRvIII and EGFR wild-type expressing cells demonstrated that these antibodies are highly specific for EGFRvIII. The antibodies were converted to ScFvs and cloned into a CAR vector. Subsequently, EGFRvIII CARs were transduced into primary human T cells for functional studies. We developed a series of assays to evaluate CAR expression, degranulation activity and target dependent cytotoxicity. Our goal is to select CAR candidate that is safe, persistent and has potent target dependent cytotoxicity.
Citation Format: Oi Kwan Wong, Mathilde Dusseaux, Jing-Tyan Ma, Melinda Au, Sophie Leduc, Joyce Chou, Jessica M. Yu, Marjorie Bateman, Thomas Pertel, Kevin C. Lindquist, Julianne Smith, Barbra Sasu, Shu-Hui Liu. Allogeneic EGFRvIII chimeric antigen receptor T cells for treatment of glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3751. doi:10.1158/1538-7445.AM2017-3751</jats:p
Per Mutations
No full textThis hybrid collection of linked essays, poems, and collages seeks to interrogate the relationship between emotional literacy and scientific literacy. The author uses ballet, grizzly bears, radioactive isotopes, infamous scientists, genetic mutations, the Apollo missions, and other subjects to hold beside her own experiences so that she might better understand how to cope with the death of a loved one. Particularly, in this collection, the author seeks to understand the difference between what endures and what remains through a chain reaction of creative, emotional, and scientific inquiry
Charles Barbra : «Esquisse de la vie d\u27un vitruose»（III） (traduction japonaise avec notes et présentation)
No full text- …
