4,119 research outputs found
Securing javascript runtime of OPC UA deployments
No full textOPC UA is a commonly used machine-to-machine communication protocol. As it is used in industrial critical infrastructure, its security is vital. OPC UA has several proprietary and open-source implementations in different programming languages. Among them, a JavaScript implementation node-opcua stands out due to advantages such as ease of use, code maturity etc. JavaScript is a just-in-time compiled programming language that is executed by a runtime system. Node.js is the most common runtime environment to run JavaScript programs. Deno is it a potential and unofficial successor as it is developed by the original author of Node.js. One promised improvement of Deno is the focus on higher security, such as having a restricted file system and network access by default. Since (1) not all libraries have been adopted yet for for Deno, since (2) this new runtime comes with a compatibility mode featured first in version v1.15, since (3) there is very few research literature yet and since (4) there is no current dedicated OPC UA implementation for Deno so far, we present and evaluate measures to overcome errors when running node-opcua on Deno in this paper
MULTIDISCIPLINARY APPROACHES AND INTERACTION NETWORK IN THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS
No full textThe multidisciplinary approaches described and reported in the present thesis were performed with the aim to gain new insight into Rheumatoid Arthritis (RA), multifactorial, progressive and autoimmune disease.
The case-control study, focused on the genetic occurrence risk of RA in a complete Italian casuistry, reported the HLA-DQA2 rs9275595 T>C variant strongest associated to RA susceptibility. SNP × SNP investigation revealed significant synergic combined effect between HLA-DQA2 rs9275595 and HLA-DRB1 rs660895 A>G variants, suggesting that, beyond single variant association, the powerful gain arises from interaction between variants belonging to HLA complex.
The predictive biomarkers identification of occurrence, progression and therapy efficacy has been carried out in Undifferentiated Arthritis/ Early Rheumatoid Arthritis patients (UA/ERA). Follow-up after 6 months from the first visit has allowed to stratify subjects accordingly to disease evolution (from UA to RA) and to disease progression (from ERA to RA) using DAS28 variation (Disease Activity Score). Interaction study between genetics and serological parameters reported a significant combined effect of Rheumatoid Factor (RF), resistin and HLA-DRB1 rs6910071 A>G, playing a role together to predict "best responders", the group of patients with higher DAS28 improvement.
Focusing on the influence of sexual dimorphism, a statistical significant gender-dependent effect has been shown in the context of Methtotrexate (MTX) pharmacogenetics: RA women D/I for HLA-G 14bp D>I variant reported significant higher MTX inefficacy, whereas male trend of association was completely opposite. Investigating on women previous obstetric history, it came out the association between the ascertained pregnancies, HLA-G 14bp D/I genotype and MTX inefficacy.
Thus, we focused the approach on the particular women-view, underlying how pregnancy and miscarriage could exert an important and discriminant role in the disease pathogenesis. Pregnancy represents a physiological context requiring immune tolerance toward the fetus and, especially during the first trimester, exists a bidirectional trafficking of cells and DNA in the fetus-maternal interface that can results in naturally acquired microchimerism in both mother (fMC) and fetus. Male fMC could be detected in women bloodstream even after many years from the childbirth and in fact, our findings revealed the presence of male fMC in SLE patients' bloodstream. The widespread symptoms of SLE could justify the higher presence of fMC than which has detected in RA patients' bloodstream and the investigation on localized RA affected synovium might be crucial to understating fMC role. Exploring women synovial biopsies, it failed to reveal positive detection of fMC, empathizing that microchimeric cells can exert a rescue role, acting as stem cells repairing tissues injuries; thus, it has possible to detect fMC cells only in slight or mild RA cases.
Finally, we explored the epigenetic profile, through the methylation analysis of LINE-1 and of specific genes HLA-G and MTHFR. Study has been carried out on healthy subjects, passing through early symptoms, to established RA diseased patients. HLA-G gene was significant hypermethylated in female RA patients, respect to RA males. Significant hypomethylation was identified in MTHFR gene, with a progressive rising to the increase of disease establishment, suggesting that epigenetic state persists beyond RA stages.
In conclusion, the evidences presented in this thesis underlined the interaction network as the important causative factor of RA susceptibility and therapy efficacy. In addition, results on RA affected women emphasized the gender medicine application. Lastly, the epigenetic study is the first to explore methylation status over the time and progression of RA disease, highlighting the environmental contribution and opening new directional window in the RA knowledge.I differenti approcci multidisciplinari affrontati e descritti nella presente tesi sono stati effettuati con l'intento di arricchire le conoscenze in ambito di Artrite Reumatoide (AR), patologia a eziologia multifattoriale, progressiva ed autoimmune.
Lo studio caso-controllo, focalizzato sull'individuazione di un profilo genetico di rischio in pazienti italiani con diagnosi di AR, ha riportato la variante HLA-DQA2 rs9275595 T>C significativamente associata ad insorgenza. L'analisi delle interazioni SNP × SNP ha rivelato un significativo effetto sinergico della combinazione fra le varianti HLA-DQA2 rs9275595 e HLA-DRB1 rs660895 A>G, suggerendo che, oltre al singolo effetto, il risultato maggiore si ha dall'interazione fra varianti appartenenti al complesso HLA.
L'identificazione di biomarkers predittivi di suscettibilità, di progressione e di efficacia del trattamento impiegato è stata condotta in pazienti con Artrite Indifferenziata/Artrite Reumatoide Precoce (UA/ERA). Il follow-up a 6 mesi ha consentito la stratificazione dei soggetti UA in base all'insorgenza o meno della patologia, mentre per i pazienti ERA in base alla variazione del DAS28 (Disease Activity Score). I risultati delle interazioni genetiche e sierologiche relativamente alla progressione di AR, hanno individuato un algoritmo predittivo di efficacia terapeutica, evidenziando una relazione sinergica fra il Fattore Reumatoide (RF), la Resistina e la variante HLA-DRB1 rs6910071 A>G.
Focalizzandosi sullo studio del dimorfismo sessuale, è stato riportato un significativo effetto genere-dipendente nel contesto della farmacogenetica del Methotrexate (MTX): infatti la variante HLA-G 14bp D>I costituisce un fattore predittivo dell'inefficacia del MTX solo nelle pazienti femmine.
Approfondendo l'indagine su peculiari caratteristiche del genere femminile che possano interagire con il genotipo HLA-G, è risultata una forte associazione fra la presenza di precedenti gravidanze accertate, il genotipo HLA-G 14bp D/I e l'inefficacia al MTX.
Considerando l'elevata espressione di HLA-G a livello del trofoblasto e il suo coinvolgimento nelle poliabortività, è stato indagato il microchimerismo fetale (fMC), già noto per essere presente nel sangue di donne affette da patologie autoimmuni, come AR e Lupus Eritematoso Sistemico (LES), anche dopo molti anni dalla gravidanza o dall'evento abortivo. Lo studio caso-controllo ha rilevato significativa presenza di fMC maschile nel campione ematico periferico di pazienti lupiche. La sintomatologia sistemica di LES potrebbe giustificare l'elevata presenza di fMC maschile nelle pazienti lupiche rispetto alle pazienti AR. Indagando le biopsie sinoviali di donne affette da AR, non è stata rivelata presenza di fMC maschile, suggerendo il possibile ruolo delle cellule microchimeriche come elementi di supporto e di rescue nel miglioramento della patologia. Sarebbe, dunque, possibile individuare cellule fMC solo nei casi di pazienti con AR stabile o in fase di remissione.
Infine, è stata esplorato il profilo epigenetico attraverso analisi di metilazione di LINE-1 e dei geni HLA-G e MTHFR, su soggetti sani di controllo, su pazienti con artrite agli esordi e su pazienti con diagnosi accertata di AR. HLA-G ha evidenziato una significativa ipermetilazione nelle pazienti donne con AR rispetto agli uomini; mentre MTHFR ha rivelato una significativa ipometilazione, gradualmente maggiore a seconda della progressione di AR.
In conclusione, i risultati esposti nella presente tesi hanno evidenziato il network di interazioni come importante elemento causativo di insorgenza e risposta terapeutica di AR. Inoltre, il focus sulle pazienti donne affette da AR ha enfatizzato l'applicazione della medicina di genere; infine, lo studio di epigenetica è il primo ad indagare lo stato di metilazione e la progressione di AR, sottolineando l'importanza del contributo ambientale e consentendo una nuova direzione esplorativa
Replication Data for: SOLUTION OF THE PROBLEM OF TRANSFORMATION OF THE VALUES OF COMMODITIES INTO THE PRICES OF PRODUCTION (CALCULATIONS)
No full textAbstract
In this paper, the author presents fundamentally new methods for transforming the value of commodities into original and equilibrium prices of production using Marx's five-sphere tables from the third volume of Capital. Mathematical verification of models is performed by method sequential iterations and using the Wolfram Mathematica program. It also presents the method of inverse transformation of prices of production of commodities into values. Proved that pricing systems based on the principles of value and price of production are not mutually exclusive, they complement each other, representing a single whole. A comprehensive solution to the transformation problem shows that Marx does not have the mistakes attributed to him by critics.
JEL classification: B14, B16, B24, E11, E20, E21, E22, P16, P17
Keywords: Karl Marx, transformation problem, mechanisms, original transformation, individual sphere of production, equilibrium price of production, real wages, direct and inverse transformation, iteration methods, mathematical verification
UA Informa contribution to attract prospective students: an exploratory study
No full textStudent recruitment rates are essential for Higher Education institutions’ sustainability. Universities may try to attract prospective students by providing information in their institutional website, advertising or offering campus visits, among other initiatives. In this line, the “UA Informa” is a project towards the promotion of extension activities for the community, to promote the image of the University of Aveiro (UA) and enhance education for sustainability. The project is relevant to UA students, prospective students, and other visitors. In this context, a set of open educational resources was developed to be accessed through QR codes spread across the campus. This exploratory study analyses the contribution of a non-formal game-based university campus visit into two dimensions: a) promotion of the institution's image; and b) students’ satisfaction with the proposed activity. The game prompts the players to find nine points of interest with specific QR codes, resulting on a path through the campus. A total of 23 students attending grade 10, from a school out of the UA influence zone, participated in the campus visit. At the end, students filled in an individual and anonymous questionnaire exposing their opinion on the experience. The students revealed an overall favorable perception on the university and game-based
campus visit, as they classified the activity as interesting and with good value for learning about the university. Nineteen students considered they would like to attend a UA course in the future (after grade 12), although many presented a neutral position regarding this possibility. This study indicates that the UA Informa may enhance the university image to capture
prospective students, but its utility does not end here, as it may also facilitate the integration of students who attend the UA for the first time, and opens the university to the overall community. Furthermore, the QR codes are a visible and practical way to provide outreach and promote involvement of the community with sustainability issues, so it might have impact in the society sustainable habits as well.publishe
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Recovering an Irish Voice from the American Frontier
No full textRecovering an Irish Voice from the American Frontier is a bilingual compilation of stories by Eoin Ua Cathail, an Irish emigrant, based loosely on his experiences in the West and Midwest. The author draws on the popular American Dime Novel genre throughout to offer unique reflections on nineteenth-century American life. As a member of a government mule train accompanying the U.S. military during the Plains Indian Wars, Ua Cathail depicts fierce encounters with Native American tribes, while also subtly commenting on the hypocrisy of many famine-era Irish immigrants who failed to recognize the parallels between their own plight and that of dispossessed Native peoples. These views are further challenged by his stories set in the upper Midwest.
His writings are marked by the eccentricities and bloated claims characteristic of much American Western literature of the time, while also offering valuable transnational insights into Irish myth, history, and the Gaelic Revival movement. This bilingual volume, with facing Irish-English pages, marks the first publication of Ua Cathail’s work in both the original Irish and in translation. It also includes a foreword from historian Richard White, a comprehensive introduction by Mahoney, and a host of previously unpublished historical images
Chirurgia Ambulatoriale e Day Surgery. Raccolta delle Lezioni del Corso di Perfezionamento
No full textNanook News, Vol. 09, No. 10 (November 2, 1967)
No full textUA COWS TOPS IN ALASKA -- ARTIST TO OPEN TWO-WEEK EXHIBIT -- COMPUTER SHORT COURSE OFFERED -- LOUISE OBER WINS KEIM LITERARY AWARD -- AUTHOR, AUTHOR!! -- PRIVATE PILOT GROUND SCHOOL TO BE OFFERED -- "J.B." ENDS RUN THIS WEEKEND -- INTERNATIONAL CLUB PLANS "SLIDE NIGHT" -- DONNER HONORED FOR WORK WITH POLAR STAR -- VETERAN'S CLUB TO SPONSOR CEREMONY -- HEADBOLT HEATER POLICY BEING PREPARED -- FILM FARE -- ACTIVITY CALENDAR, November 2 - 9, 196
Letter from Ois�n Ua Mor�in to Fr. O'Callaghan
No full textHolograph letter from Ois�n Ua Mor�in of The New Leader, 205 New Brunswick Street, Dublin, to Fr. O'Callaghan [Rome]. The author of the article is happy if his name is disclosed to Dr. O'Hagan and will be glad to be in communication with him; he is Fr. E. Carroll in Crayford, Kent
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