1,721,086 research outputs found
2013 Lush Training Prize: Anna Maria Bassi’s Research Team, Laboratory of Analysis and Research of Physiopathology (LARF), Department of Experimental Medicine, University of Genova,
No full textinterview to Author for winning Lush Prize 2013 for the efforts to encourage training programmes
aimed at the dissemination of the knowledge,information and skills needed to promote and
support the increased use of available andaccepted non-animal test methods and testing
strategies by regulators and end-users in industryand academia
Modulation of antioxidant status in a macrophage cell line during chronic exposure to glycated serum.
No full textModulation of antioxidant status in a macrophage cell line during chronic exposure to glycated serum
No full textModulation of antioxidant status in a macrophage cell line during chronic exposure to glycated seru
Hepatoma cell cultures as in vitro models for the hepatotoxicity of xenobiotics
No full textHepatoma cell cultures as in vitro models for the hepatotoxicity of xenobiotic
Inauguration of the Centro 3R for the promotion of 3Rs principles in teaching and research
Full text linkThe first European interuniversity center dedicated to promoting
3Rs principles in teaching and research was inaugurated in
Pisa, Italy on March 14, 2018. The Centro 3R1 was spearheaded
by the Universities of Pisa and Genova. Membership is open to
all Italian universities and agreements for twinning across Europe
and other countries are being pursued
Biochemical properties of carcinogen-metabolizing enzymes in cultured hepatoma cells
No full textmodulation of carcinogen-metabolizing enzymes in cultured hepatoma cell
Comparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-β-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines.
No full textIndian frankincense is a gum resin from Boswellia serrata of Burseraceae used in Ayurveda and Western medicine for the antinflammatory effects of boswellic acids, particularly 3-O-acetyl-11-keto--boswellic acid (AKBA).We evaluated in vitro cytotoxicities of B. serrata extract and AKBA on differentiated and undifferentiated keratinocytes (HaCaT and NCTC 2544), and foetal dermal fibroblasts (HFFF2), using neutral red uptake (NRU), MTT, and DNA assays. Comparison between NRU and MTT, and between the extract and AKBA, suggested a relatively higher toxicity of both substances on lysosomes respect to mitochondria. Extract cytotoxicity on lysosomes was higher in NCTC and HFFF2 than on the more differentiated HaCaT. DNA assay showed low extract inhibition on HFFF2 proliferation, possibly due to lower growth rate, and a stronger
effect on NCTC than on HaCaT, possibly related to higher proapoptotic effect on the less differentiated NCTC, as also suggested by higher AKBA toxicity on NCTC than on HaCaT. In general, gum resin and AKBA toxicities were slightly lower or higher than that of the reference compound SDS. Our in vitro model allowed to compare the sensitivities of different human skin cells to B. serrata, and indicated that the gum resin and AKBA exert moderate to low toxicity on the skin
Induction of sister-chromatid exchanges in Chinese hamster ovary cells of biotic ketoaldehyde methylglyoxal.
No full textInduction of sister-chromatid exchanges in Chinese hamster ovary cells of biotic ketoaldehyde methylglyoxal
- …
