110 research outputs found
Data for: Chemopreventive effects of vitamin D3 and its analogue, Paricalcitol, in combination with 5-Fluorouracil against colorectal cancer: The roles of calcium signalling molecules
No full textRaw data of animal studies including tumor characteristics, serum VD levels, tissue levels of Ca2+, oncogenes, tumor suppressor molecules and Ca2+-related molecules with the different therapie
Data for: Vitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat.
No full textVitamin D protects against oxidative stress, inflammation and hepatorenal damage induced by acute paracetamol toxicity in rat
Data for: Enhanced remedial effects for vitamin D3 and Calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules
No full textThe data contains the raw materials of the study titled: 'Enhanced remedial effects for vitamin D3 and Calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules.&apos
DS_10.1369_0022155418782696 – Supplemental material for Acute and Chronic Iron Overloading Differentially Modulates the Expression of Cellular Iron-homeostatic Molecules in Normal Rat Kidney
No full textSupplemental material, DS_10.1369_0022155418782696 for Acute and Chronic Iron Overloading Differentially Modulates the Expression of Cellular Iron-homeostatic Molecules in Normal Rat Kidney by Bassem Refaat, Abdelghany Hassan Abdelghany, Mohammad A. BaSalamah, Mohamed El-Boshy, Jawwad Ahmad and Shakir Idris in Journal of Histochemistry & Cytochemistry</p
Refaat Alareer’s “If I Must Die”: The Death of the Author, the Afterlife of the Tale
No full textThis article traces the performative role of tales and storytelling in late Refaat Alareer’s life, career, (creative) writing, activism, and death. It ultimately examines this performativity’s intensification and culmination in Alareer’s Saidian late-style poem “If I Must Die.” The article combines close textual analysis and comparative literary criticism to investigate the intricate relationship between storytelling, mortality, and resistance in Alareer’s poem. Paying attention to nuance, the article examines the poem’s intertextual connections with Claude McKay’s “If We Must Die” (1919) to demonstrate how Alareer transforms storytelling into a powerful mode of cultural survival and a means of transcending physical destruction and preserving collective memory in the face of systematic oppression. Additionally, the research traces Alareer’s evolving conceptualization of storytelling from a personal imperative to a collective form of resistance, culminating in “If I Must Die” whose stylistic and thematic treatment of his impending death anchor his poem locally/nationally, namely in Gaza/Palestine
Aspects of the molecular biology of ectopic pregnancy : The role of activins and inducible nitric oxide synthase
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats
No full textOsama Adnan Kensara,1,* Adel Galal El-Shemi,2,3,* Amr Mohamed Mohamed,2,4 Bassem Refaat,2 Shakir Idris,2 Jawwad Ahmad2 1Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Holy Makkah, Saudi Arabia; 2Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Holy Makkah, Saudi Arabia; 3Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt; 4Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt *These authors contributed equally to this work Abstract: Colorectal cancer (CRC) is one of the most prevalent cancers and has a high mortality rate. Insensitivity and the limited therapeutic efficacy of its standard chemotherapeutic drug, 5-fluorouracil (5-FU), represents an important challenge in CRC treatment. The robust antitumor properties of thymoquinone (TQ), the main bioactive constituent of Nigella sativa, have recently been demonstrated on different cancers. We investigated whether TQ could potentiate the chemopreventive effect of 5-FU to eradicate the early stages of CRC and elucidated its underlying mechanisms. An intermediate-term (15 weeks) model of colorectal tumorigenesis was induced in male Wistar rats by azoxymethane (AOM), and the animals were randomly and equally divided into five groups: control, AOM, AOM/5-FU, AOM/TQ, and AOM/5-FU/TQ. TQ (35 mg/kg/d; 3 d/wk) was given during the seventh and 15th weeks post-AOM injection, while 5-FU was given during the ninth and tenth weeks (12 mg/kg/d for 4 days; then 6 mg/kg every other day for another four doses). At week 15, the resected colons were subjected to macroscopic, histopathological, molecular, and immunohistochemical examinations. Interestingly, 5-FU/TQ combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors and large aberrant crypts foci than treatment with the individual drugs. Mechanistically, 5-FU and TQ remarkably cooperated to repress the expression of procancerous Wnt, β-catenin, NF-κB, COX-2, iNOS, VEGF, and TBRAS and upregulate the expression of anti-tumorigenesis DKK-1, CDNK-1A, TGF-β1, TGF-βRII, Smad4, and GPx. Overall, our findings present the first report describing the in vivo enhancement effect of combined TQ and 5-FU against early stages of CRC; however, further studies are required to determine the value of this combination therapy in an advanced long-term model of CRC and also to realize its clinical potential. Keywords: colorectal tumors, thymoquinone, 5-fluorouracil, combination therapy, rat
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