1,721,556 research outputs found

    104. Mandilaras (Basile G.) Ὁ περὶ εἰρήνης λόγος τοῦ Ἰσοκράτους

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    Boyaval B. 104. Mandilaras (Basile G.) Ὁ περὶ εἰρήνης λόγος τοῦ Ἰσοκράτους. In: Revue des Études Grecques, tome 91, fascicule 434-435, Juillet-décembre 1978. pp. 613-614

    Atésès (Basile G.), Ἱστορία τῆς Ἐκκλησίας τῆς Σκύρου (Άρχεῖον Εὐβοϊκῶν μελετῶν)

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    Janin Raymond. Atésès (Basile G.), Ἱστορία τῆς Ἐκκλησίας τῆς Σκύρου (Άρχεῖον Εὐβοϊκῶν μελετῶν). In: Revue des études byzantines, tome 20, 1962. p. 262

    Remarks on the management of proximal femoral fractures in times of COVID-19 pandemic

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    Proximal femoral fractures (PFFs) are among the main causes of hospitalization of elderly patients. They are often challenging to manage at the perioperative stage, which is why appropriate monitoring is recommended in order to prevent and - whenever possible - avoid foreseeable complications (infections, bedsores, bronchopneumonia, psychicological deterioration and worsening general conditions), reduce the mortality rate, facilitate functional recovery and restore the patient's ability to walk and return to everyday life activities and a normal family context. PFFs constitute a major adverse event for elderly patients, often over the age of eighty and with possible issues arising from a substantially unstable and deficient biological balance, with negative repercussions on their quality of life, longer hospitalization and higher healthcare costs. The COVID-19 pandemic has severely impacted the healthcare systems of virtually all world countries, giving rise to serious operational management difficulties (e.g. surgical staff shortages, less availability of surgical facilities, reassignment of surgical staff to other tasks, the need to convert facilities into intensive care units and dedicated COVID + operating rooms, reconfiguration of pathways and procedures with longer anesthesiological and surgical preparation times, environmental sanitation, etc.). All such factors have prolonged waiting times for surgery, causing higher complications rates especially in fragile patients. It is essential to operate through a timely multidisciplinary approach for PFF patients, who must be treated surgically as soon as possible in order to limit the risk of secondary complications due to prolonged bed rest and facilitate a rapid functional recovery

    Beneficial effects of music in the healing process of traumatic injuries: perceptual control of suffering and possible abatement of disability conditions

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    Abstract: Numerous scientific studies report that listening to music can beneficially affect physical and mental health, and even expedite the healing process of traumatic conditions. One of the most noteworthy positive effects of music lies in its ability to control stress and anxiety by lowering heart rate, blood pressure and blood cortisol levels. Furthermore, music can help improve mood especially in traumatized people who are faced with a wide range of negative emotions, reducing symptoms of depression and stimulating the production of dopamine in the brain, favorably inducing sleep quality, thanks to the their relaxing action. Listening to music can stimulate brain activity and improve short-term memory and concentration, having positive effects on the healing process of traumatic pathologies. Therefore, music should be considered a complementary treatment option for people facing treatment for traumatic pathologies, also stimulating the production of endorphins in the brain and intervening on pain control, resulting in positive effects on the quality of life of the traumatized. Furthermore, music can help people express their emotions and communicate with others, providing a way to connect with the world and share similar experiences, reducing social isolation and improving emotional well-being

    Basile G. Spiridonakis, Grecs, Occidentaux et Turcs de 1054 à 1453 : quatre siècles d'histoire de relations internationales

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    Cheynet Jean-Claude. Basile G. Spiridonakis, Grecs, Occidentaux et Turcs de 1054 à 1453 : quatre siècles d'histoire de relations internationales. In: Revue des études byzantines, tome 50, 1992. pp. 322-323

    Diadenosine homodinucleotide products of ADP-ribosyl cyclase behave as modulators of the purinergic receptor P2X7

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    ADP-ribosyl cyclases from both vertebrates and invertebrates were previously shown to produce two isomers of P1,P2 diadenosine 5',5'"-P1, P2-diphosphate, P18 and P24, from cyclic ADP-ribose (cADPR) and adenine. P18 and P24 are characterized by an unusual N-glycosidic linkage in one of the adenylic mononucleotides (Basile, G., Taglialatela-Scafati, O., Damonte, G., Armirotti, A., Bruzzone, S., Guida, L., Franco, L., Usai, C., Fattorusso, E., De Flora, A., and Zocchi, E. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 14509-14514). P24, but not P18, proved to increase the intracellular Ca(2+) concentration ([Ca(2+)](i)) in HeLa cells and to negatively affect mitochondrial function. Here we show that micromolar P24, but not P18, triggers a slow and sustained influx of extracellular Ca(2+) through the opening of the purinergic receptor/channel P2X7. On the other hand, P18 inhibits the Ca(2+) influx induced by 0.6 mm ATP in HEK293 cells stably transfected with P2X7, with an IC(50) of approximately 1 mum. Thus, P18 is devoid of intrinsic P2X7 stimulatory activity and behaves as an ATP antagonist. A P2X7-mediated increase of the basal [Ca(2+)](i) has been demonstrated to negatively affect Schwann cell (SC) function in rats with the inherited, peripheral neuropathy Charcot-Marie-Tooth 1A (CMT1A) (Nobbio, L., Sturla, L., Fiorese, F., Usai, C., Basile, G., Moreschi, I., Benvenuto, F., Zocchi, E., De Flora, A., Schenone, A., and Bruzzone S. (2009) J. Biol. Chem. 284, 23146-23158). Preincubation of CMT1A SC with 200 nm P18 restored the basal [Ca(2+)](i) to values similar to those recorded in wild-type SC. These results identify P18 as a new P2X7 antagonist, potentially useful in the treatment of CMT1A

    A Complex Adaptive System Framework for Management and Marketing Studies

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    This theoretical work aims to analyze the choice of strategicmanagement activities, taking into account a complex systems perspective. Following this approach, we represent the firm as a complex adaptive system, in which the management must be able to develop and implement different behaviors in order to dynamically ensure the viability of the firm or system. This implies that the management governing the firm or system is capable of choosing, from among a number of heterogeneous entities, the relevant stakeholders within the competitive context and of creating and maintaining significant relationships with them, which are considered to be relevant in a turbulent environment. As an expression of the relational dynamics between the direct and indirect stakeholders, the firm exchanges energy and information with the reference contexts, in order to survive. As part of these exchanges and adaptations, both the firm and its stakeholders disperse energy, producing a dissipative phenomenon (Prigogine I, Order out of chaos. In: Livingston P (ed) Disorder and order: proceedings of the Stanford international symposium (Sept. 14–16, 1981). Anma Libri, Saratoga, pp 41–60, 1984), which we describe—in an analogy with the second law of thermodynamics and complexity theory—as entropy. Our research question is thus: Can complex adaptive systems theory help decision makers to deal with the dynamism of organizations and brand in turbulent environments? Through a theoretical and descriptive framework, we will draw our conclusions to this research question
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