2,100 research outputs found
JunB/AP-1 controls MM cell proliferation, survival and drug resistance in the bone marrow microenvironment
No full textThe AP-1 transcription factor JunB promotes multiple myeloma (MM) cell proliferation, survival and drug resistance in the bone marrow microenvironment
No full textThe AP-1 Transcription Factor JunB Promotes Multiple Myeloma (MM) Cell Proliferation, Survival and Drug Resistance in the Bone Marrow Microenvironment
No full textIntermediate Filaments in Breast Cancer Progression, and Potential Biomarker for Cancer Therapy: A Narrative Review
No full textWidad Aghnia Shalannandia,1 Yoan Chou,2 Muhammad Hasan Bashari,1,3 Astrid Feinisa Khairani1,3 1Graduate School of Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Jatinangor, West Java, Indonesia; 2Graduate School of Master Program in Anti Aging and Aesthetic Medicine, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Jatinangor, West Java, Indonesia; 3Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, Jatinangor, West Java, IndonesiaCorrespondence: Astrid Feinisa Khairani, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jalan Raya Bandung – Sumedang Km 21, Jatinangor, Sumedang, West Java, 45363, Indonesia, Tel +62-22-7795594, Email [email protected]: Intermediate filaments are one of the three components of the cytoskeletons, along with actin and microtubules. The intermediate filaments consist of extensive variations of structurally related proteins with specific expression patterns in cell types. The expression pattern alteration of intermediate filaments is frequently correlated with cancer progression, specifically with the epithelial-to-mesenchymal transition process closely related to increasing cellular migration and invasion. This review will discuss the involvement of cytoplasmic intermediate filaments, specifically vimentin, nestin, and cytokeratin (CK5/CK6, CK7, CK8/CK18, CK17, CK19, CK20, CSK1), in breast cancer progression and as prognostic or diagnostic biomarkers. The potential for drug development targeting intermediate filaments in cancer will be reviewed. Keywords: breast malignancy, cytokeratin, EMT, intermediate filament, keratin, nestin, vimenti
Non-alloy Mg anode for Ni-MH batteries: Multiple approaches towards a stable cycling performance
No full textMg attracts much research interest as anode material for Ni-MH batteries thanks to its lightweight, cost-effectiveness and high theoretical capacity (2200 mA h g−1). However, its practical application is tremendously challenged by the poor hydrogen sorption kinetics, passivation from aggressive aqueous electrolytes, and insulating nature of MgH2. Mg-based alloys exhibit enhanced hydrogen sorption kinetics and electrical conductivity, but significant amount of costly transition metal elements are required. In this work, we have, for the first time, utilized non-alloyed but catalyzed Mg as anode for Ni-MH batteries. 5 mol.% TiF3 was added to nanosized Mg for accelerating the hydrogen sorption kinetics. Several strategies for preventing the problematic passivation of Mg have been studied, including protective encapsulation of the electrode and utilizing room-temperature/high-temperature ionic liquids and an alkaline polymer membrane as working electrolyte. Promising electrochemical performance has been achieved in this Mg–TiF3 composite anode based Ni-MH batteries with room for further improvements.</p
Assessing risk of self-harm in acute paediatric settings: A multicentre exploratory evaluation of the CYP-MH SAPhE instrument
No full textOBJECTIVE: To psychometrically assess the Children and Young People-Mental Health Self-harm Assessment in Paediatric healthcare Environments (CYP-MH SAPhE) instrument for the identification of immediate risk of self-harm in CYP, aged 10-19 years, in acute paediatric wards or emergency departments., DESIGN: The CYP-MH SAPhE Instrument was developed through a robust scoping review and Delphi consensus with 30 clinicians/topic experts. To evaluate the psychometric properties, a multicentre exploratory study was conducted., SETTING: Three acute hospitals in the UK., PARTICIPANTS: 163 CYP presenting at acute hospital settings with primary mental health (cases) or physical health (non-cases) conditions., PRIMARY AND SECONDARY OUTCOME MEASURES: Psychometric properties of the CYP-MH SAPhE instrument were evaluated through Principle Axis Factoring (PAF) with Oblimin (Kaiser normalisation) alongside measures of internal consistency (Cronbach's alpha), convergent, discriminant and face validity., RESULTS: PAF of the dichotomous items (n=9) loaded onto three factors (1) behaviours and intentions; (2) suicidality and (3) self-harm. Factors 1 (Cronbach's alpha=0.960) and 3 (Cronbach's alpha=1) had high internal consistency. There was: good level of agreement between raters (kappa=0.65); a moderately positive correlation between the CYP-MH SAPhE instrument and the Columbia-Suicide Severity Rating Scale; and discrimination between cases and non-cases across the three factors (factor 1: m=88 vs 70; factor 2: m=102 vs 70; factor 3: m=104 vs 68). Assessment of face validity resulted in six items being removed, culminating in an eight question, rapid assessment instrument., CONCLUSIONS: The results support the CYP-MH SAPhE Tool as a potentially reliable and valid instrument to identify immediate risk of self-harm in CYP presenting to acute paediatric healthcare environments, which is a burgeoning and significant global health issue. Copyright © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.https://dx.doi.org/10.1136/bmjopen-2020-04376
Soyghurt Potentially Controls the Level of sFlt1 and PLGF in Preeclampsia Maternal Serum-Induced Placental Trophoblast Cell in vitro
No full textAstrid Feinisa Khairani,1 Uci Ary Lantika,2 Julia Ramadhanti,1 Muhammad Hasan Bashari,1,3 Widad Aghnia Shalannandia,1 Tenny Putri Wikayani,4 Achadiyani Achadiyani,1 Mulyanusa Amarullah Ritonga5 1Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, West Java, Indonesia; 2Department of Biomedical Sciences, Faculty of Medicine, Universitas Islam Bandung, Bandung, West Java, Indonesia; 3Research Centre of Oncology and Stem Cell, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 4Culture and Cytogenetic Laboratory, Universitas Padjadjaran, Bandung, West Java, Indonesia; 5Department of Obstetrics and Gynecology, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, IndonesiaCorrespondence: Astrid Feinisa Khairani, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jalan Raya Bandung – Sumedang Km 21, Jatinangor, West Java, 45363, Indonesia, Tel +62-22-779559445363, Email [email protected]: To observe the effect of soya yoghurt (Soyghurt), which is high in flavonoid substance, on the expression of preeclampsia biomarkers (sFLT-1 and PLGF) on preeclampsia serum-induced trophoblast primary cell culture isolated from placental tissue.Methods: The trophoblast primary culture was induced by preeclampsia serum (10%). The Soyghurt treatment was performed with 2.5%, 5%, and 7.5% Soyghurt supernatant concentrations in culture media. The expression of preeclampsia markers, sFLT-1 and PLGF, were evaluated using ELISA.Results: Expression of sFLT-1 on preeclampsia-induced cell culture treated with Soyghurt was significantly lowered compared to the untreated group (p 0.05).Conclusion: This study demonstrates the potential effect of Soyghurt’s in balancing preeclampsia marker expression by inhibiting the expression of sFLT-1 in preeclampsia serum -induced trophoblast cells.Keywords: preeclampsia, PLGF, sFLT-1, soya yoghurt, trophoblas
The times; or, the age of ruin. A poem. [electronic resource] : By the author of "A poetical and complimentary epistle to R. Brothers the prophet, and N. B. Halhed, Esq;" &c.
No full textPublication date from MH-H.Electronic reproduction.English Short Title Catalog,Reproduction of original from Harvard University Houghton Library
[The] lady's watch. [electronic resource] : By the author of The prude.
No full textVerse - "A fair one sought the silent poplar shade".'The prude, a tale.' was first published in Dublin in 1722.MH-H copy may be cropped at head, affecting first word of titleFoxon,Electronic reproduction.English Short Title Catalog,Reproduction of original from Harvard University Houghton Library
Between Mother and Son: Preparation of the assambly MH+-
No full textEl presente informe recopila los detalles y el proceso creativo de la obra de danza MH+-, donde se reunieron los saberes académicos en términos prácticos, teóricos y experienciales, apropiados por el estudiante y autor de la obra en mención y este texto, Ricardo Nieto Ortíz. En esta obra se tomó como inspiración temática la relación personal de dicho estudiante y su madre, desde el momento en que este se identificó frente a ella como un hombre homosexual. El proceso de creación se llevó a cabo a través de un laboratorio de investigación creación con seis intérpretes creadores, incluido Ricardo Nieto, durante seis meses, con cuatro etapas de desarrollo utilizando herramientas como la improvisación, la creación de personajes y la ejercitación de los imaginarios que nutren los procesos creativos de los intérpretes.This report compiles the details and the creative process of the dance work MH+-, where the academic knowledge in practical, theoretical and experiential terms was gathered, appropriated by the student and author of the work in question and this text, Ricardo Nieto Ortiz. In this work, the personal relationship of this student and his mother was taken as thematic inspiration, from the moment he identified himself in front of her as a homosexual man. The creation process was carried out through a creation research laboratory with six creative interpreters, including Ricardo Nieto, for six months, with four stages of development using tools such as improvisation, the creation of characters and the exercise of the imaginaries that nourish the creative processes of the performers
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