15 research outputs found
232 Establishing Quality and Universal Access for LGBTQIA2+ Patients (EQUAL)
No full textOBJECTIVES/GOALS: LGBTQIA2+ patients experience many healthcare inequities and often do not seek healthcare due to stigma andprevioustraumatic experiences in the healthcare system. A paucity of healthcare centersprovidesreduced-fee or free healthcare to LGBTQIA2+ individuals. METHODS/STUDY POPULATION: This project was initiated by the primary author who volunteered at an established student-run free clinic in Columbus, OH. The primary author engaged other students and faculty members, including the co-authors. A needs assessment was conducted by the authors, highlighting the unique needs of LGBTQIA2+ patients in central Ohio. In April 2022, members of the community and volunteer faculty providers established the Rainbow Clinic. The Rainbow Clinic provides primary care services including sexual health/STI testing and gynecology care. The Rainbow Clinic exclusively serves members of the LGBTQIA2+ community in central Ohio and creates a safe and inclusive space to educate medical and nurse practitioner students on the care of LGBTQIA2+ patients in a culturally sensitive way. RESULTS/ANTICIPATED RESULTS: The Rainbow Clinic has provided care for 60 patients equating to 78 visits. Most patients sought care for general primary care (17.9%), gynecological care (11.5%) or STI testing and treatment (7.7%). In addition to medical services, social work services are also provided as part of available mental health services and to provide additional linkage to care. To our knowledge, The Rainbow Clinic is the first student-run free clinic in Ohio to offer pre-exposure HIV prophylaxis (PrEP) medication as well as the required laboratory monitoring. The Rainbow Clinic has ongoing research evaluating patient comfortability throughout their encounters and has launched research studies to evaluate how best to address social determinants of health that affect the health and healthcare of the LGBTQIA2+ community. DISCUSSION/SIGNIFICANCE: The Rainbow Clinic deliversfree healthcareand social work servicesto patients who experience healthcare inequities anddisparities.Additionally, the Rainbow Clinic is a source of education for medical and nurse practitionerstudents to ensure their cultural humility in treating future LGBTQ+ patients
111 Evaluating Patient Influences on Comfortability for LGBTQIA2+ Patients in Clinical Spaces (EPIC)
No full textOBJECTIVES/GOALS: The objective of this project was to evaluate the factors that contribute to LGBTQIA2+ patient comfortability. This information was then used to understand how best to create a comfortable space for LGBTQIA2+ patients. METHODS/STUDY POPULATION: This survey was focused on underinsured and uninsured patients seen at the Rainbow Clinic - a free student-run LGBTQIA2+ clinic. Surveys were distributed by undergraduate volunteers on tablets as a qualtrics survey. Surveys collected demographic information in addition to 5 questions that assessed patient comfortability. These questions included evaluating the patient’s comfort with sharing information with the provider and the patient’s comfort of coming into clinical spaces. These surveys were distributed before and after clinic appointments to capture any changes in comfortability that could have occurred as a result of the appointment. RESULTS/ANTICIPATED RESULTS: Up to May of 2023, 49 patients were seen in Rainbow Clinic. 33 patients filled out the intake survey and 31 patients filled out the check-out survey resulting in a 67% and 63% response rate respectively. Questions were asked on a likert scale (1-5) from Strongly Disagree to Strongly Agree. Questions evaluating patient comfort in sharing information with their provider yielded an average score that was statistically significant, suggesting patients felt comfortable at the Rainbow Clinic. Additionally, patients indicated that the LGBTQIA2+ specific labeling of the Rainbow Clinic made them significantly more comfortable coming into the clinic. DISCUSSION/SIGNIFICANCE: This project suggests that patient comfortability can be improved by training and intentional LGBTQIA2+ labeling. Considering the hesitancy of this community towards healthcare, improving comfortability not only benefits clinical care and outcomes but can also bolster the body of research on this community
533 Student Undergrad Researchers’ Race, Ethnicity, And Language in a Student-Run Free Clinic (SURREAL)
No full textOBJECTIVES/GOALS: Our primary objective is to determine the demographic and linguistic characteristics of student research assistants (SRAs) in a large student-run free clinic associated with a mid-western university. Our secondary objective was to determine if the SRAs perceived any impact of those characteristics on their duties and ability to conduct research. METHODS/STUDY POPULATION: We plan to conduct a 15-question electronic survey of Student Research Assistants at the student run free clinic. There are a variety of projects that require varying levels of commitment from researchers, which will be aggregated. This survey has been modified from a previously validated survey that focused on the demographic and linguistic characteristics of pediatric research coordinators. This survey will be emailed out to student research assistants and will be done over a period of 3 months. The study population will be predominantly undergraduate students who are all interested in a career in healthcare, ages expected to range from 18-25. RESULTS/ANTICIPATED RESULTS: We anticipate that the majority of student research assistants will be older students and will be students who identify as non-white/caucasian, as the majority of students volunteering at this free clinic do not identify as white. Additionally, we anticipate that students will feel that their racial/ethnic identity will positively impact their recruitment efforts. We also anticipate that the ability of a student research assistant to speak another language is expected to positively affect their perceived recruitment efforts. We also anticipate that gender will influence the student researchers’ perceptions of their recruitment efforts. DISCUSSION/SIGNIFICANCE: An individual’s background can directly impact how they perceive their contributions towards research. Considering the paucity in research for underinsured and uninsured and the rise in undergraduate student research assistants, optimizing research efforts and SRA confidence is essential to increase the accuracy and efficiency of research
A Call for Collaboration: Knowledge Dissemination to Improve the Emergency Care of Children
No full textThe Siberian Branch of the Shibanid Dynasty in Sh. Marjani’s Studies
No full textObjectives and research materials: In 1885, Shihabuddin Marjani wrote the work “Mustafa al-Akhbar fi ahwal Kazan va Bulgar” (“The Mine of Information about Events in Kazan and Bulghar”). By analyzing chapters of the history on the Siberian branch of the Shibanid dynasty, the author of the present article aims to identify the main sources for the hypotheses proposed by S. Marjani. In the part of the work published in Russian, there are several stories related to representatives of the branch of the Shibanid dynasty who were enthroned in Tyumen and Siberia. Stories about them are scattered in various sections: “Section about the Toqtamishids”, “Section about the New State with the Capital in Kazan”, “Section about the Kasimov Khanate in the Lands of Kirman”, “Section about the Siberian Khans”. In addition, some information is available in the “Section about the Sheibanid Khans” and “Section about the Sheibanids Who Ruled in Mawarannahr”.
Results and novelty of the research: A comparison of Marjani’s accounts with the sources published in Russian at that time allows us to suggest that Marjani could have made use of “The Genealogical Tree of the Turks” by Abu-l-Ghazi, the “Sheibaniade” by an unknown author and published in Kazan in 1849 by I. Berezin, the “Collection of Materials Relating to the History of the Golden Horde” by V. Tizengauzen (Volume I. Extracts from Arabic sources), and “Studies of the Kasimov Tsars and Princes” by V.V. Velyaminov-Zernov. With a certain degree of probability, he also could have used the work, “Mukim-Khan’s history” by Muhammad Yusuf Munshi. In such a case, Marjani was apparently the first historian in the Russian milieu who used Munshi’s text and briefly reviewed the history of the formation and collapse of the Uzbek khanate of Abu al-Khair. Although suffering from certain factual flaws, the work of Marjani contained important information on the history of the Shibanids. Moreover, in some cases, the author’s assumptions were ahead of the historical scholarship of his time; for example, regarding the khan’s titles of Ali and Ishim. This observation indicates the need for further research into the sources used by this author
Hâfız-ı Ebrû'nun Mecma'u't-tevârîh isimli eserinin ismâilîler kısmı (giriş-tercüme-değerlendirme)
No full textBu çalışma, Hâfız-ı Ebrû’nun hayatı, eserleri ve tarihçiliği hakkında bilgi vermek ve Mecmaʿu't-tevârîh isimli eserinin İsmâilîler kısmının çevirisini sunmayı amaçlamaktadır. Hâfız-ı Ebrû, Timurlu döneminin ünlü İranlı coğrafyacısı ve tarihçisidir. Ancak, onun hayatı hakkında çok fazla bilgi bulunmamaktadır ve doğum yeri, unvanları ve lakapları konusunda da bazı tartışmalar vardır. Hâfız-ı Ebrû olarak meşhur Şihabüddîn Abdullah b. Lütfûllah b. Abdilreşid el-Bihdadinî el-Hâvafî, Herat’a bağlı Bihdadin köyünde dünyaya gelmiştir. Hamedan’da eğitim görmüş ve yükselmiştir. İsmi Abdullah olan müellifin Künyesi Şihabüddîn, Lakabı da Hâfız-ı Ebrû’dur. Batı Literatüründe daha çok Hâfız-ı Ebrû olarak anılmaktadır. Tarih ve coğrafya alanlarında son derece yetkin birisi olan Hâfız-ı Ebrû gençlik yıllarından itibaren Emir Timur’un dikkatini çekmiş ve onun satranç arkadaşı olmuştur. Emir Timur’a yakınlığı sayesinde onun seferlerine katılma fırsatı bulmuş, hem elçi olarak görevlendirilmiş hem de seferler sırasında mühendis olarak da görev almıştır. Bu konumu sayesinde hem Timur döneminde hem de onun halefleri olan Şahruh Mirza ve Baysungur döneminde yaşanan hâdiseleri eserlerinde detaylı bir şekilde aktarabilmiştir. Eserlerinde sade bir dil kullanmayı tercih eden Hâfız-ı Ebrû, tarih ve coğrafya alanlarında birçok eser kaleme almıştır. Onun tarih alanında çalışmaları oldukça değerlidir. Bu alanda kaleme alınan, çalışmanın da konusunu oluşturan “Mecma‘u't-tevârîh” ya da tam adıyla “Mecmaʿu’t-tevârîhi’s-sultâniyye” önemli bir umumî tarih niteliğindedir. Yine onun kaleme aldığı “Mecmûʿa-i hâfız-ı ebrû” önemli bir derleme niteliğindedir. Onun “zeyl” çalışması da bulunmaktadır. Bu önemli zeylin ismi Zeyl-i Câmiʿu’t-tevârîh-i reşidî’dir ve bu eser adında da anlaşılacağı üzere Reşîdüddîn Fazlulah-ı Hamedânî’nin Câmiʿu’t-tevârîh isimli eserine yapılmış bir zeyldir. Coğrafya alanında da çalışması olan müellifin eseri “Coğrafya-yi hâfız-ı ebrû”dur. Müellif bu eserinde İslâm dünyasının önemli yerleri hakkında detaylı bilgiler vrmiştir. Tarih ve coğrafya alanında oldukça önemli eserler kaleme alan Hâfız-ı Ebrû, 25 Haziran 1430 yılında Azerbaycan’dan, Şahruh’un Karakoyunlularla yaptığı savaşın dönüşünde Zencân yakınlarındaki Serçem’de vefat etmiş ve naaşı Zencân’a taşınan Hâfız-ı Ebrû, Şeyh Ebü’l-Ferec-i Zencânî’nin türbesine defnedildimiştir.This work aims to provide information about the life, works, and historiography of Hafiz-i Abru and to present the translation of the Ismaili section of his work “Mecmaʿu't-tevârîh.” Hafiz-i Abru was a renowned Iranian geographer and historian during the Timurid period. However, there is limited information about his life, and there are debates about his birthplace, titles, and nicknames. Shihabuddin Abdullah bin Lutfullah bin Abdilreshid al-Bihdadini al-Hawafi, famously known as Hafiz-i Abru, was born in the village of Bihdadin near Herat. He received education in Hamedan and rose to prominence. The author, whose name is Abdullah, is known by the kunya Shihabuddin, and his nickname is Hafiz-i Abru, though he is more commonly referred to as Hafiz-i Abru in Western literature. Highly proficient in history and geography, Hafiz-i Abru drew the attention of Emir Timur from his youth and became his chess companion. Thanks to his proximity to Emir Timur, he had the opportunity to participate in military campaigns, serving both as an envoy and an engineer. His position allowed him to narrate events in detail during the Timurid era and the reigns of Timur’s successors, Shahrukh Mirza and Baysunghur. Preferring a simple language in his works, Hafiz-i Abru authored numerous works in the fields of history and geography. His contributions to the field of history are particularly valuable, with “Mecma‘u't-Tevârîh” or “Mecmaʿu’t-tevârîhi’s-sultâniyye” being a significant general history. Another notable compilation is “Mecmûʿa-i Hâfız-ı Abrû.” He also wrote a supplemental work named “Zeyl-i Câmiʿu’t-tevârîh-i Reşidî,” an addition to Rashid al-Din Fazlullah Hamedani's “Câmiʿu’t-tevârîh.” In the field of geography, Hafiz-i Abru’s work “Coğrafya-yi Hâfız-ı Abrû” provides detailed information about important locations in the Islamic world. Hafız-ı Abru, who wrote very important works in the fields of history and geography, passed away on June 25, 1430, near Zencan, on his return from Azerbaijan after Shahrukh’s battle with the Kara Koyunlu. His remains were transported to Zencan, where he was buried in the tomb of Sheikh Abul-Faraj Zencani
Research Priorities for Pediatric Emergency Care to Address Disparities by Race, Ethnicity, and Language
No full textIMPORTANCE: Health care disparities are well-documented among children based on race, ethnicity, and language for care. An agenda that outlines research priorities for disparities in pediatric emergency care (PEC) is lacking.
OBJECTIVE: To investigate research priorities for disparities in PEC among medical personnel, researchers, and health care-affiliated community organizations.
DESIGN, SETTING, AND PARTICIPANTS: In this survey study, a modified Delphi approach was used to investigate research priorities for disparities in PEC. An initial list of research priorities was developed by a group of experienced PEC investigators in 2021. Partners iteratively assessed the list through 2 rounds of electronic surveys using Likert-type responses in late 2021 and early 2022. Priorities were defined as achieving consensus if they received a score of highest priority or priority by at least 60% of respondents. Asynchronous engagement of participants via online web-conferencing platforms and email correspondence with electronic survey administration was used. Partners were individuals and groups involved in PEC. Participants represented interest groups, research and medical personnel organizations, health care partners, and laypersons with roles in community and family hospital advisory councils. Participants were largely from the US, with input from international PEC research networks.
OUTCOME: Consensus agenda of research priorities to identify and address health care disparities in PEC.
RESULTS: PEC investigators generated an initial list of 27 potential priorities. Surveys were completed by 38 of 47 partners (80.6%) and 30 of 38 partners (81.1%) in rounds 1 and 2, respectively. Among 30 respondents who completed both rounds, there were 7 family or community partners and 23 medical or research partners, including 4 international PEC research networks. A total of 12 research priorities achieved the predetermined consensus threshold: (1) systematic efforts to reduce disparities; (2) race, ethnicity, and language data collection and reporting; (3) recognizing and mitigating clinician implicit bias; (4) mental health disparities; (5) social determinants of health; (6) language and literacy; (7) acute pain-management disparities; (8) quality of care equity metrics; (9) shared decision-making; (10) patient experience; (11) triage and acuity score assignment; and (12) inclusive research participation.
CONCLUSIONS AND RELEVANCE: These results suggest a research priority agenda that may be used as a guide for investigators, research networks, organizations, and funding agencies to engage in and support high-priority disparities research topics in PEC
Pediatric Firearm Injury Emergency Department Visits From 2017 to 2022: A Multicenter Study.
No full textBone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study
No full textWe explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3, 6 and 12 months. Assessment at 3-6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5-7, stabilization in 1-7, and worsening in 1-7 patients. MRI at 3 months revealed new or enlarging lesions in 5-7 and Gadolinium (Gd+) enhancing lesions in 3-7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5-6 and worsening in 1-6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events. © 2010 Elsevier B.V.Assmus B, 2006, NEW ENGL J MED, V355, P1222, DOI 10.1056-NEJMoa051779; Bai LH, 2009, GLIA, V57, P1192, DOI 10.1002-glia.20841; CAROLL WM, 2010, NEW ENGL J MED, V362, P456; Couri CEB, 2006, BRAZ J MED BIOL RES, V39, P1271, DOI 10.1590-S0100-879X2006005000010; Freedman MS, 2010, MULT SCLER J, V16, P503, DOI 10.1177-1352458509359727; Gerdoni E, 2007, ANN NEUROL, V61, P219, DOI 10.1002-ana.21076; Gordon D, 2008, NEUROSCI LETT, V448, P71, DOI 10.1016-j.neulet.2008.10.040; Grigoriadis N, 2002, CLIN NEUROL NEUROSUR, V104, P251, DOI 10.1016-S0303-8467(02)00048-3; Horwitz EM, 2001, BLOOD, V97, P1227, DOI 10.1182-blood.V97.5.1227; Horwitz EM, 1999, NAT MED, V5, P309, DOI 10.1038-6529; Karussis D, 2008, CLIN NEUROL NEUROSUR, V110, P889, DOI 10.1016-j.clineuro.2008.02.008; Karussis D, 2008, J NEUROL SCI, V265, P131, DOI 10.1016-j.jns.2007.05.005; KASSIS I, 2008, ARCH NEUROL-CHICAGO, V65, P754; Koc ON, 2002, BONE MARROW TRANSPL, V30, P215, DOI 10.1038-sj.bmt.1703650; Krampera M, 2006, CURR OPIN PHARMACOL, V6, P435, DOI 10.1016-j.coph.2006.02.008; Lunde K, 2006, NEW ENGL J MED, V355, P1199, DOI 10.1056-NEJMoa055706; Martino G, 2010, NAT REV NEUROL, V6, P247, DOI 10.1038-nrneurol.2010.35; Mazzini L, 2006, NEUROL RES, V28, P523, DOI 10.1179-016164106X116791; Mazzini L, 2010, EXP NEUROL, V223, P229, DOI [10.1016-j.expneurol.2009.08.007, 10.1016-j.expneuro1.2009.08.007]; MURRAY TJ, 2009, J NEUROL SCI S1, V277, P3; Patrikios P, 2006, BRAIN, V129, P3165, DOI 10.1093-brain-awl217; Payne N, 2008, J AUTOIMMUN, V31, P288, DOI 10.1016-j.jaut.2008.04.002; Phinney DG, 1999, J CELL BIOCHEM, V75, P424, DOI 10.1002-(SICI)1097-4644(19991201)75:3424::AID-JCB83.0.CO;2-8; Pluchino S, 2009, NEUROSCI LETT, V456, P101, DOI 10.1016-j.neulet.2008.03.097; Polman CH, 2005, ANN NEUROL, V58, P840, DOI 10.1002-ana.206703; Schachinger V, 2006, NEW ENGL J MED, V355, P1210, DOI 10.1056-NEJMoa060186; Scolding N, 2008, J NEUROL SCI, V265, P111, DOI 10.1016-j.jns.2007.08.009; Shihabuddin LS, 2010, NEUROPHARMACOLOGY, V58, P845, DOI 10.1016-j.neuropharm.2009.12.015; Slavin S, 2008, CLIN NEUROL NEUROSUR, V110, P943, DOI 10.1016-j.clineuro.2008.01.014; TALAN J, 2009, NEUROL TODAY, V9, P12; Uccelli A, 2007, REGEN MED, V2, P7, DOI 10.2217-17460751.2.1.7; Uccelli A, 2006, EXPERT OPIN BIOL TH, V6, P17, DOI 10.1517-14712598.6.1.17; UCELLI A, 2010, CURR OPIN NEUROL, V23, P218; Vosoughi R, 2010, CLIN NEUROL NEUROSUR, V112, P365, DOI 10.1016-j.clineuro.2010.03.010; Watorek E, 2006, ARCH IMMUNOL THER EX, V54, P45, DOI 10.1007-s00005-006-0004-4; Wiendl H, 2009, NEUROLOGY, V72, P1008, DOI 10.1212-01.wnl.0000344417.42972.54; Yang JX, 2009, J NEUROL SCI, V276, P1, DOI 10.1016-j.jns.2008.08.020; Zappia E, 2005, BLOOD, V106, P1755, DOI 10.1182-blood-2005-04-1496; Zhang J, 2005, EXP NEUROL, V195, P16, DOI 10.1016-j.expeneurol.2005.03.01877827
Cepheid Xpert Xpress Flu/RSV evaluation performed by minimally trained non-laboratory operators in a CLIA-waived environment
No full textThe COVID-19 pandemic highlighted the significance of readily available and easily performed viral testing for surveillance during future infectious pandemics. The objectives of this study were: to assess the performance of the Xpert Xpress Flu and/or RSV test, a multiplex PCR assay for detecting influenza A and B virus and respiratory syncytial virus nucleic acids in respiratory tract specimens, relative to the Quidel Lyra Influenza A+B assay and the Prodesse ProFlu+ assay, and the system's ease of use by minimally trained operators. Overall, the Xpert Xpress Flu/RSV test demonstrated a high positive and negative percent agreement with the comparator assays, and was easy to use and interpret results, based on the operators’ feedback. We concluded that the Xpert Xpress Flu/RSV test is sensitive, specific, and easy to use for the diagnosis of influenza and RSV by minimally trained operators and can be a valuable tool in future infectious clusters or pandemics
