50 research outputs found
Iyigün Cocuk Klasikleri
No full textThe seller describes the book as rare. Its cover features six black-and-white illustrations from standard fables starting with MM and finishing with FS. The book is richly illustrated with full-page and partial-page black-and-white designs, often two to a fable. Here is a curiosity: the small design showing the lion's teeth being removed is a slightly different picture from the full-page presentation of the same scene on 146. I suspect the same holds true for the other five pictures on the cover. This is a sleeper of a book. I look forward to a patient walk through its illustrations. It is not difficult to recognize each La Fontaine fable from its cartoon. The cover adds red for background of text information and green for three of the fable cartoons.Language note: TurkishJean de La Fontaine; Nermin Milar
Frequencies of gap- and tight-junction mutations in Turkish families with autosomal-recessive non-syndromic hearing loss
No full textMutations in genes encoding gap- and tight-junction proteins have been shown to cause distinct forms of hearing loss. We have now determined the GJB2 [connexin 26 (Cx26)] mutation spectrum in 60 index patients from mostly large Turkish families with autosomal-recessive inherited non-syndromic sensorineural hearing loss (NSSHL). GJB2 mutations were found in 31.7% of the families, and the GJB2- 35delG mutation accounted for 73.6% of all GJB2 mutations. The carrier frequency of GJB2- 35delG in the normal Turkish population was found to be 1.17% (five in 429). In addition to the described W24X, 233delC, 120delE and R127H mutations, we also identified a novel mutation, Q80R, in the GJB2 gene. Interestingly, the Q80R allele was inherited on the same haplotype as V27I and E114G polymorphisms. As little is known about the mutation frequencies of most other recently identified gap- and tight-junction genes as a cause for hearing loss, we further screened our patients for mutations in GJB3 (Cx31), GJA1 (Cx43), DeltaGJB6 -D13S1830 (Cx30) and the gene encoding the tight-junction protein, claudin 14 (CLDN14 ). Several novel polymorphisms, but no disease-associated mutations, were identified in the CLND14 and GJA1 genes, and we were unable to detect the DeltaGJB6 -D13S1830 deletion. A novel putative mutation, P223T, was found in the GJB3 gene in heterozygous form in a family with two affected children. Our data shows that the frequency of GJB2 mutations in Turkish patients with autosomal-recessive NSSHL and the carrier rate of the GJB2- 35delG mutation in the Turkish population, is much lower than described for other Mediterranean countries. Furthermore, mutations in other gap- and tight-junction proteins are not a frequent cause of hearing loss in Turkey
A novel homozygous COL11A2 deletion causes a C-terminal protein truncation with incomplete mRNA decay in a Turkish patient
No full textRecessive mutations in COL11A2 (collagen, type XI, alpha 2), are responsible for otospondylomegaepiphyseal dysplasia (OSMED) and non-syndromic hearing loss while dominant mutations are associated with Stickler type III, isolated cleft palate, Robin sequence, non-ophthalmic Stickler syndrome, early onset osteoarthritis and autosomal dominant hearing loss. We describe here the clinical findings of two Turkish cousins with OSMED carrying a novel homozygous truncating mutation in exon 38 of COL11A2 gene, c.2763delT, identified on cDNA and confirmed at gDNA. This mutation is located on triple helix repeat domain of the collagen alpha-2 (XI) chain, where the majority of the previously identified mutations are located. Real-time RT-PCR experiment provided that mutated transcript does not decay completely. Although our analysis displays the partial survival of the mutant transcript from blood tissue, not from cartilage, we propose that this mechanism may play an important role on the variable expressivity of the heterozygous COL11A2 gene mutations. (C) 2010 Wiley-Liss, Inc
Laryngofissure Cordectomy-Evaluations of Positive Margins and Survival Rates
No full textObjective: The primary aim of this study was to evaluate the results of early-stage glottic laryngeal cancer patients who underwent laryngofissure cordectomy. Results were analyzed in terms of positive margins and survival rates
The novel R75Q mutation in the GJB2 gene causes autosomal dominant hearing loss and palmoplantar keratoderma in a Turkish family
No full textDominant mutations in the GJB2 gene encoding connexin 26 (Cx26) can cause non-syndromic hearing impairment alone or in association with palmoplantar keratoderma (PPK). We have identified the novel G224A (R75Q) mutation in the GJB2 gene in a four-generation family from Turkey with autosomal dominant inherited hearing impairment and PPK. The age of onset and progression of hearing loss were found to be variable among affected family members, but all of them had more severe impairment at higher hearing frequencies. Interestingly, the novel R75Q mutation affects the same amino acid residue as described recently in a small family (R75W) with profound prelingual hearing loss and PPK. However, the R75W mutation was also observed in a control individual without PPK and unknown hearing status. Therefore, the nature of the R75W mutation remains ambiguous. Our molecular findings provide further evidence for the importance of the conserved R75 in Cx26 for the physiological function of the inner ear and the epidermal cells of the skin
Does the Addition of Hyperbaric Oxygen Therapy to the Conventional Treatment Modalities Influence the Outcome of Sudden Deafness?
No full textOBJECTIVE: To investigate the therapeutic effects of the addition of hyperbaric oxygen (HBO) therapy to the conventional therapies in sudden deafness (0) and to investigate the influence of patient age on the effectiveness of HBO therapy
Erratum: Author Correction: Evaluation of Potential Drug-Drug Interactions in the Intensive Care Unit (European review for medical and pharmacological sciences (2021) 25 18 PII: 36861 DOI: 10.26355/eurrev_202109_26798)
No full textCorrection to: Eur Rev Med Pharmacol Sci 2021; 25 (18): 5801-5806-DOI: 10.26355/eurrev_202109_26798-PMID: 34604971 published online on September 30, 2021. The methodology section of this research article incorrectly stated that the lexi-interact checker program is freely accessible. The study was conducted at Uludağ University using university-access computers. As a result, the lexi-interact program, provided through UpToDate and accessed via the university's subscription service, was mistakenly described as a free resource. Therefore, the sentence "pDDIs, defined using the lexi-interact (a free online interaction checker, provided from UpToDate, 2020, https://www.uptodate.com/drug-interactions), were classified based on the significance of the interaction level (minor, moderate, major)" has been corrected as follows: - pDDIs, defined using the lexi-interact (an online interaction checker, provided from UpToDate, 2020, https://www.uptodate.com/drug-interactions), were classified based on the significance of the interaction level (minor, moderate, major). There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/26798
Architecture and Urban Education in Egypt: Producing Designers that are Ready to Respond to the Social and Environmental Circumstances of the Egyptian Context
No full textAbstractArchitects and urban planners must be aware of the impact of their contribution to both the society and the environment, this awareness needs to be planted in their educational programs. This paper is trying to determine the social and environmental priorities in architecture and urban undergraduate programs. After discussing the trends of curricula in architecture programs the paper analyses Ain Shams university curricula as a case study. Leading the paper to determine the correct approaches that need to be taken in order to produce a generation of practitioners that are aware of the social and environmental needs of their society
De-regulation: With the work of Kutlug Ataman
No full textDiscusses the video work of Turkish film-maker Kutlug Ataman curated under the title 'De-Regulation', and the subsequent research project developed out of this entitled 'Istanbul - Skin of the City' which includes photographs, a 'visual essay' by Stefan Roemer, an archive of wedding cultures throughout Turkey assembled by Nermin Saybasili, television, posters, books and magazines. The author describes Ataman's video installations, many of which include female subjects, considers the focus on Turkish lives, examines the fictions of identification in many of the video testimonies, and comments on sexuality in the narratives. She considers what is meant by experience and comments on her interest in creolised subjects
AI in FinTechs
No full textThis article addresses the compliance of the use of Big Data and Artificial Intelligence (AI) by FinTechs with European data protection principles. FinTechs are increasingly replacing traditional credit institutions and are becoming more important in the provision of financial services, especially by using AI and Big Data. The ability to analyze a large amount of different personal data at high speed can provide insights into customer spending patterns, enable a better understanding of customers, or help predict investments and market changes. However, once personal data is involved, a collision with all basic data protection principles stipulated in the European General Data Protection Regulation (GDPR) arises, mostly due to the fact that Big Data and AI meet their overall objectives by processing vast data that lies beyond their initial processing purposes. The author shows that within this ratio, pseudonymization can prove to be a privacy-compliant and thus preferable alternative for the use of AI and Big Data while still enabling FinTechs to identify customer needs.Dieser Artikel befasst sich mit der Vereinbarkeit der Nutzung von Big Data und Künstlicher Intelligenz (KI) durch FinTechs mit den europäischen Datenschutzgrundsätzen. FinTechs ersetzen zunehmend traditionelle Kreditinstitute und gewinnen bei der Bereitstellung von Finanzdienstleistungen an Bedeutung, insbesondere durch die Nutzung von KI und Big Data. Die Fähigkeit, eine große Menge unterschiedlicher personenbezogener Daten in hoher Geschwindigkeit zu analysieren, kann Einblicke in das Ausgabeverhalten der Kunden geben, ein besseres Verständnis der Kunden ermöglichen oder helfen, Investitionen und Marktveränderungen vorherzusagen. Sobald jedoch personenbezogene Daten involviert sind, kommt es zu einer Kollision mit allen grundlegenden Datenschutzprinzipien, die in der europäischen Datenschutzgrundverordnung (DS- GVO) festgelegt sind, vor allem aufgrund der Tatsache, dass Big Data und KI ihre übergeordneten Ziele durch die Verarbeitung großer Datenmengen erreichen, die über ihre ursprünglichen Verarbeitungszwecke hinausgehen. Der Autor zeigt, dass sich in diesem Verhältnis die Pseudonymisierung als datenschutzkonforme und damit vorzugswürdige Alternative für den Einsatz von KI und Big Data erweisen kann, die FinTechs dennoch in die Lage versetzt, Kundenbedürfnisse zu erkennen
