834 research outputs found
sj-pdf-1-nax-10.1177_18479804211064028 – Supplemental Material for Facile synthesis of novel SrO <sub>0.5</sub>:MnO <sub>0.5</sub> bimetallic oxide nanostructure as a high-performance electrode material for supercapacitors
No full textSupplemental Material, sj-pdf-1-nax-10.1177_18479804211064028 for Facile synthesis of novel SrO 0.5:MnO 0.5 bimetallic oxide nanostructure as a high-performance electrode material for supercapacitors by Vinayak Adimule, Vinay S Bhat, Basappa C Yallur, Adarsha HJ Gowda, P D Padova, Gurumurthy Hegde and Arafat Toghan in Nanomaterials and Nanotechnology</p
sj-docx-1-tam-10.1177_17588359221108685 – Supplemental material for Evolving landscape of first-line combination therapy in advanced renal cancer: a systematic review
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359221108685 for Evolving landscape of first-line combination therapy in advanced renal cancer: a systematic review by Aly-Khan A. Lalani, Daniel Y. C. Heng, Naveen S. Basappa, Lori Wood, Nayyer Iqbal, Deanna McLeod, Denis Soulières and Christian Kollmannsberger in Therapeutic Advances in Medical Oncology</p
sj-docx-2-tam-10.1177_17588359221108685 – Supplemental material for Evolving landscape of first-line combination therapy in advanced renal cancer: a systematic review
No full textSupplemental material, sj-docx-2-tam-10.1177_17588359221108685 for Evolving landscape of first-line combination therapy in advanced renal cancer: a systematic review by Aly-Khan A. Lalani, Daniel Y. C. Heng, Naveen S. Basappa, Lori Wood, Nayyer Iqbal, Deanna McLeod, Denis Soulières and Christian Kollmannsberger in Therapeutic Advances in Medical Oncology</p
Chameleon of head and neck diseases: Intraoral actinomycosis
No full textActinomycosis is a chronic infectious granulomatous disease caused by saprophytic Actinomyces species. The case discussed in this report is of an adult female patient with a large actinomycotic lesion in the region of the mandibular left second premolar, first and second molars. Provisional diagnosis was made as extragingival pyogenic granuloma. Definitive diagnosis was based on histopathological examination. Since actinomycotic infection has opportunistic characteristics, early diagnosis and proper management of the disease is mandatory to prevent further complications
Cheminformatics-Based Drug Design Approach for Identification of Inhibitors Targeting the Characteristic Residues of MMP-13 Hemopexin Domain
No full textBackground:
MMP-13, a zinc dependent protease which catalyses the cleavage of type II collagen, is expressed in osteoarthritis (OA) and rheumatoid arthritis (RA) patients, but not in normal adult tissues. Therefore, the protease has been intensively studied as a target for the inhibition of progression of OA and RA. Recent reports suggest that selective inhibition of MMP-13 may be achieved by targeting the hemopexin (Hpx) domain of the protease, which is critical for substrate specificity. In this study, we applied a cheminformatics-based drug design approach for the identification and characterization of inhibitors targeting the amino acid residues characteristic to Hpx domain of MMP-13; these inhibitors may potentially be employed in the treatment of OA and RA.
Methodology/Principal Findings:
Sequence-based mutual information analysis revealed five characteristic (completely conserved and unique), putative functional residues of the Hpx domain of MMP-13 (these residues hereafter are referred to as HCR-13pf). Binding of a ligand to as many of the HCR-13pf is postulated to result in an increased selective inhibition of the Hpx domain of MMP-13. Through the in silico structure-based high-throughput virtual screening (HTVS) method of Glide, against a large public library of 16908 molecules from Maybridge, PubChem and Binding, we identified 25 ligands that interact with at least one of the HCR-13pf. Assessment of cross-reactivity of the 25 ligands with MMP-1 and MMP-8, members of the collagenase family as MMP-13, returned seven lead molecules that did not bind to any one of the putative functional residues of Hpx domain of MMP-1 and any of the catalytic active site residues of MMP-1 and -8, suggesting that the ligands are not likely to interact with the functional or catalytic residues of other MMPs. Further, in silico analysis of physicochemical and pharmacokinetic parameters based on Lipinski's rule of five and ADMET (absorption, distribution, metabolism, excretion and toxicity) respectively, suggested potential utility of the compounds as drug leads.
Conclusions/Significance:
We have identified seven distinct drug-like molecules binding to the HCR-13pf of MMP-13 with no observable cross-reactivity to MMP-1 and MMP-8. These molecules are potential selective inhibitors of MMP-13 that can be experimentally validated and their backbone structural scaffold could serve as building blocks in designing drug-like molecules for OA, RA and other inflammatory disorders. The systematic cheminformatics-based drug design approach applied herein can be used for rational search of other public/commercial combinatorial libraries for more potent molecules, capable of selectively inhibiting the collagenolytic activity of MMP-13.Lee Foundation (Singapore
Carbosulfan Induced Renal Toxicity in Albino Miceï€
No full textCarbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl insecticide cum -acaricide was administered orally at doses of 12, 24, 36 and 48 mg/ kg /d to albino mice for 30 days . Mice orally administered with similar volume of olive oil were served as control. Daily body weights were recorded and mice were sacrificed on day 31st. The kidney histology, estimations of biochemical contents and enzyme activities were carried out. The histologic examination of kidney of mice treated with 12 and 24 mg /kg/d carbosulfan revealed loss of normal arrangement of cortical tubules and formation of vacuoles. The histologic study of kidney of mice treated with 36 and 48 mg/ kg/d carbosulfan showed flattened tubular cells and formation of vacuoles. The glomeruli were small atrophied and loosely attached to Bowman’s capsule. Vacuoles are found prominently due to loss of glomeruli. Study on biochemical contents of the kidney showed that the levels of  DNA, RNA, protein and glycogen were decreased significantly but the level of cholesterol was increased significantly with 36 and 48 mg/kg/d carbosulfan treatment to male and female mice, except in male mice the DNA, RNA and cholesterol were not changed significantly with 36 mg/kg/d carbosulfan. Treatment with 24 mg/kg/d carbosulfan caused significant decrease in the levels of protein and glycogen in female and male mice. Study on the activity of enzymes revealed that the treatment with 36 and 48 mg/kg/d carbosulfan caused significant decrease in the activity of SDH, Na+-K+ATPase, Mg++ATPase, Ca++ATPase and ACP but there was a significant increase in the activity of LDH, ASAT, ALAT, AKP in kidney of both female and male mice .The results of the present study suggest that the carbosulfan might have affected cellular metabolism , active transport of ions across cell membrane, cellular defense mechanism and elimination system in kidney and it was dose dependent .---1Department of Biotechnology, C.M.R.I.T, Bangalore-37, Karnataka, India; 2P.G. Department of Studies in Biotechnology and Microbiology, Karnatak University, Dharwad – 580 003, India---Please Cite This Article As:  Raghavendra L. Ksheerasagar and Basappa B. Kaliwal. 2010. Carbosulfan Induced Renal Toxicity in Albino Mice. J. Exp. Sci. 1(8):17-22
Checklist of the grasses of India
No full textA checklist of the grasses of India is presented, as compiled from survey of all available literature. Of the twelve subfamilies of grasses, ten are represented in India. Most subfamilies have been examined by taxonomic experts for up-to-date nomenclature. The list includes 1506 species plus infraspecific taxa and presents information on types, synonyms, distribution within India, and habit. Twelve new combinations are made, viz. Arctopoa tibetica (Munro ex Stapf) Prob. var. aristulata (Stapf) E.A. Kellogg, comb. nov.; Chimonocalamus nagalandianus (H.B. Naithani) L.G. Clark, comb. nov.; Chionachne digitata (L.f.) E.A. Kellogg, comb. nov.; Chionachne wallichiana (Nees) E.A. Kellogg, comb. nov.; Dinebra polystachyos (R. Br.) E.A. Kellogg, comb. nov.; Moorochloa eruciformis (Sm.) Veldkamp var. divaricata (Basappa & Muniv.) E.A. Kellogg, comb. nov.; Phyllostachys nigra (Lodd. ex Lindl.) Munro var. puberula (Miq.) Kailash, comb. & stat. nov.; Tzveleviochloa schmidii (Hook. f.) E.A. Kellogg, comb. nov.; Urochloa lata (Schumach.) C.E. Hubb. var. pubescens (C.E. Hubb.) E.A. Kellogg, comb. nov.; Urochloa ramosa (L.) T.Q. Nguyen var. pubescens (Basappa & Muniy.) E.A. Kellogg, comb. nov.; Urochloa semiundulata (Hochst. ex A. Rich.) Ashalatha & V.J. Nair var. intermedia (Basappa & Muniy.) E.A. Kellogg, comb. nov
Dataset of "Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer"
No full textCompendium of Mathematical Models for Aircraft Parameter Estimation
No full textThis report is a compendium of several linear and and non-linear mathematical models useful for parameter estimation and data compatibility checking from flight data. It includes models for longitudinal, lateral-directional and performance characterisation of aircraft
Studies Towards All Solid-State Batteries with Garnet-type Solid Electrolytes and Lithium Metal Anode
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