1,354,971 research outputs found
Implications and problems in analysing cytotoxic activity of hydroxyurea in combination with a potential inhibitor of ribonucleotide reductase.
No full textThe 2,2'-bipyridyl-6-carbothioamide copper (II) complex differs from the iron (II) complex in its biochemical effects in tumor cells, suggesting possible differences in the mechanism leading to cytotoxicity.
No full textDetection of a novel HLA-B allele, HLA-B*08:111, in an Italian bone marrow donor
No full textThe newly detected HLA-B*08:111 allele shows two nucleotide differences from B*08:01:01 in codons 113 and 114. © 2013 John Wiley & Sons A/S.The newly detected HLA-B*08:111 allele shows two
nucleotide differences from B*08:01:01 in codons 113 and
114
Use of flashlamp-pumped pulsed dye laser in the treatment of superficial vascular malformations and ulcerated hemangiomas
No full textA retrospective study of 502 patients treated with tunable flashlamp pulsed dye laser for superficial vascular malformations (433), ulcerated hemangiomas (65) and postinvolutional redness (4) is presented. Patients were treated in the period from June 1997 to March 2006, with follow-up ranging from six months to four years. The age of the patients ranged from three months to 80 years. Correlation between clinical response and patients' age, location of lesion and number of treatments were evaluated in groups of superficial vascular malformations, whereas healing rates of the ulceration were assessed in a series of hemangiomas. The result were judged to be excellent in 51%, good in 39%, fair in 7% and poor in 3% of patients with vascular malformations. Excellent ultimate outcome confirmed the clinical efficacy of the use of the pulsed dye laser in the treatment of dermal vascular malformations, which also appears to have good prospects in the management of hemangioma complication
Essays on Tertiary Education: Access to University, Student Loans and Economic Independence.
No full textQuesta tesi raccoglie tre articoli che analizzano alcune delle scelte affrontate dagli studenti per ottenere il titolo universitario.
Tali articoli sono stati realizzati nell'ambito del progetto STAREBEI, finanziato dalla Banca Centrale Europea, per un'indagine sui prestiti d'onore coordinato dal Dipartimento di Scienze Economiche dell'Università di Verona.
Nell'ambito dell'indagine sono stati intervistati 2.703 studenti frequentanti la classe quinta di 50 scuole superiori del Veneto e 3.580 studenti universitari. Attraverso un questionario online sono state raccolte informazioni molto dettagliate sulle condizioni socio-economiche dei rispondenti.
Il primo capitolo mette in relazione la scelta di andare all'università con l'eterogeneità degli studenti di quinta superiore.
Il secondo capitolo si concentra invece sull'attitudine degli studenti di chiedere un prestito d'onore allo scopo di frequentare l'università.
Il terzo capitolo analizza come l'emancipazioni economica sia prevalente tra gli studenti, descrivendo il profilo di chi desidera una certa autonomia economica dai genitori.
All'interno di ogni capitolo, in particolare il primo e il secondo, vengono indicate le misure di policy più adeguate per incentivare le scelte oggetto dell'analisi.This thesis contains three essays on the economics of tertiary education, an investment that has important consequences on the economic and social outcomes of individuals, leading
through the first challenges in the transition from youth to adulthood. The research uses a sample of high school leavers of the Veneto region, located in the North-East of Italy, and a
nationwide sample of university students.
The first chapter analyzes how circumstances and individual responsibilities relate to the intention to enroll in tertiary education, using the sample of high school leavers from the
Veneto region. Multinomial logit analysis reveals that the student's enrollment choice is not related to the household income. It is also found that family circumstances have a lower
impact than individual characteristics and personal efforts. Therefore, school talent, both innate and acquired through personal efforts, is a necessary prerequisite to justify further
investments in tertiary education by families.
The second study investigates how student's circumstances, individual characteristics and attitudes relate to the decision to take up a student loan. In general, students are not interested in student loans as an instrument to equalize opportunities of access, since in Italy tuition fees are very low and all the Italian universities issue degrees with a legal value.
It is found that working students, students enrolled in university at a later stage and students wishing to change universities are relatively more willing to take up a student loan. Italian youngsters see student loans mainly as a means to emancipate from their families. Income is an important factor and is negatively correlated with the willingness to take up a loan.
Loan and debt averse students are not prone to borrow independently of income. Good students with superior earning prospects show a higher propensity to borrow. Risk and time
preferences, differently from previous studies, do not seem relevant determinants of the loan choice. Italian families still act as an insurance mechanism against the risks embedded in
the investment in human capital.
The third chapter examines the relationship between the aspiration to gain economic independence from parents and circumstances, individual characteristics and measures of individual efforts. Youth emancipation is the final outcome of a set of factors: constructive parental family ties, freedom in choosing the adequate living arrangement, fulfillment of educational and working aspirations, economic independence and active participation in social and emotional life. It is found that 53% of the high school and 60% of the university respondents claim for economic independence from their parents. Italian youngsters are
not as comfortable as traditionally believed with their economic dependence on parental resources. Estimation results show that individual characteristics are the main determinants of the aspiration to economic independence. These are important findings since they imply that government policies designed to encourage the development of youth preferences and
attitudes have the potential to encourage economic emancipation
Early evaluation of a new 2,2'-bipyridyl derivative with potential inhibitory activity on the ribocleotide reductase enzyme
No full text2,2'-Bipyridyl-6-carbothioamide (Bpyta) is an interesting compound, characterized by the N*-N*-S* tridentate ligand system [1]. It demonstrated in vitro antitumoral activity much higher than hydroxyurea (Hu) on murine and tumoral lines and on human acute leukemias; it seems to be active on the key enzyme ribonucleotide reductase (RR), M2 subunit [2]. In order to verify if the introduction of another carbothioamidic group in 6' position of Bpyta can potentiate antitumor activity of this compound, 2,2'-Bypyridyl-6,6'-dicarbothioamide (Bpy-dita) was synthesized.
We evaluate cytotoxic activity of the new molecule on a panel of tumoral cell lines (P388, C-26, B16, CHO and HL-60) by using an antimetabolic assay. Bpy-dita was found more potent than 10 times with respect to Bpyta and more than 100 times with respect to Hu. Bpy-dita concentration resulting in 50% inhibition of radioisotope incorporation ranged between 72 and 610 nM. The compound was insoluble in water and was dissolved in Dimethyl sulfoxide (DMSO) until a concentration of 2 mM and in a solution 25% polyethylene glycol (Peg) until a concentration of 0.1 mM. Final concentration of DMSO and Peg did not have any cytotoxic effect on our testing systems.
Such a result suggests Bpy-dita is a highly cytotoxic compound. To evaluate its mechanism of action we are going to test its inhibitory activity on RR.
[1] Antonini, I et al 1981, J Med Chem 24, 1181.
[2] Nocentini G et al 1990, Proc XI Int Congress of Pharmacology, Amsterda
An in vitro assay for evaluating chemosensitivity of leukaemia cells: preclinical studies
No full textThe present study was aimed at defining the standard conditions for predictive chemosensitivity testing of human leukaemias. The in vitro cytotoxic potential of 11 anticancer drugs against L1210 murine leukaemia was comparatively determined 3 and 48 h after in vitro exposure of leukaemia cells to these agents. In preliminary testing, drug-induced damage was estimated in terms of percent inhibition of: tumour cell proliferation, by microscopic determination of viable cell numbers; and DNA synthesis, by measuring the extent of incorporation of the labelled nucleoside 125IUdR. Since the two tests appeared to yield comparable results, all subsequent experiments on the various murine tumours were performed using the radiolabel incorporation technique. The results obtained pointed out that this metabolic assay performed 48 hours after drug exposure appears to be capable of predicting both "spontaneous" and "induced" in vivo resistance of murine leukaemias
Systolic blood pressure diabetes and the risk of cardiovascular diseases in the Asia-Pacific region
No full textOBJECTIVE: To assess the association between systolic blood pressure (SBP) and cardiovascular diseases (CVD) among participants with and without diabetes from cohorts in the Asia-Pacific region. RESEARCH DESIGN AND METHODS: Hazards ratios and 95% confidence intervals (CI) for CVD were calculated from Cox models, stratified by sex and region and adjusted for age using individual participant data from 36 cohort studies. Repeat measurements of SBP were used to adjust for regression dilution bias. RESULTS: During follow-up, 7387 fatal or non-fatal cardiovascular endpoints were recorded among 368 307 participants (6.4% with diabetes). SBP was associated with coronary heart disease (CHD), ischaemic stroke and haemorrhagic stroke in a continuous log-linear fashion among individuals with diabetes, as well as those without diabetes. Overall, each 10 mmHg higher usual SBP was associated with 18% (95% CI: 9-27%) and 23% (19-26%) greater risk for CHD among those with and without diabetes, respectively. The corresponding values for ischaemic stroke were 29% (14-45%) and 43% (37-50%), and for haemorrhagic stroke, 56% (32-83%) and 74% (66-82%). The test for heterogeneity by diabetes status in each of these associations was not significant (P >or= 0.10). CONCLUSIONS: Systolic blood pressure is an important marker of risk of CVD in people with and without diabetes. A given reduction in systolic blood pressure is likely to have a similar relative effect on reducing the risk of a cardiovascular event, regardless of diabetes status.Asia Pacific Cohort Studies Collaboration, Kengne AP, Patel A, Barzi F, Jamrozik K, Lam TH, Ueshima H, Gu DF, Suh I, Woodward M
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