1,730 research outputs found
A first look at "Who's the Murderer?" by Eleanor Sleath
No full text"Who's the Murderer?" was published in 1802 by Eleanor Sleath, who is named as an author of one of the 'horrid novels' in Northanger Abbey. This paper discusses some details of what is known about Eleanor Sleath, and discusses the editing process as well as giving a short summary of the book and some of the gothic elements, with particular reference to Sleath's principal influence, Ann Radcliffe's Mysteries of Udulpho
Eleanor Barnes Pierce talks about her grandfather, Lansing Mayor Orlando Mack Barnes, and his influence on the development of post-Civil War Michigan
No full textGift of Margaret O'Rourke.Eleanor Barnes Pierce talks about her father, Lansing Mayor Orlando Mack Barnes and his influence on the development of post-Civil War Lansing and Michigan. Pierce is interviewed by Margaret O'Rourke and James Billings. Pierce recalls her childhood in the Barnes mansion and talks about her family and their lifestyle and their daily lives. O'Rourke describes the mansion as viewed in a number of photos, reads from Orlando Barnes' biography, Eleanor's wedding announcement and the obituaries of Orlando Barnes and his wife. Following the interview Billings and O'Rourke visit the site of the mansion which was demolished in 1957, describe what they see and speculate on the extent of the property. They also visit Evergreen Cemetery and the Barnes family grave site and read from headstones
Agnes and Eleanor Barnes working on Easter cascarones
No full text''Misses Agnes and Eleanor Barnes, the charming little daughters of Mr. and Mrs. Raymond Barnes, are shown working on their cascarones (toy bombs) for Easter morning...'
Agnes and Eleanor Barnes working on Easter cascarones
No full text''Misses Agnes and Eleanor Barnes, the charming little daughters of Mr. and Mrs. Raymond Barnes, are shown working on their cascarones (toy bombs) for Easter morning...'
A Gisha
No full textDoctor Eleanor J. Smith is an African American studies educator, musician, university system chancellor, author, and visual artist. Dr. Smith was faculty member of the University of Cincinnati’s Afro-American Studies Department and William Patterson University. After obtaining a doctorate in African American studies and becoming a university professor, Dr. Smith wrote and directed performances about the Black experience during the 1970s
Implications of HCV genotype 3 specific immunity on cross-reactive vaccine design
No full textHepatitis C virus (HCV) is a major global pathogen that infects an estimated 170 million people worldwide, and for which currently no vaccine is available. HCV is a highly diverse viral pathogen and exists as 6 major genotypes sharing only 75% sequence homology; developing a vaccine that is cross-reactive between genotypes is a major challenge. Defining immune responses that target different HCV genotypes will facilitate pan-genotypic T cell vaccine development. HCV genotype 3 (gt3) is now the most common infecting genotype in the United Kingdom and large parts of Asia; however, data regarding the T cell antigenic targets of this genotype is very limited. In this thesis, HCV gt3 specific T cell targets were defined in acute, chronic and spontaneously resolved infection: in chronic gt3 infection, T cell responses were low in magnitude and narrowly focused in specificity, similar to those previously reported for gt1; in contrast, resolved infection was associated with a higher magnitude and broader specificity of CD4+ and CD8+ T cell responses across the genome. Overall, T cell specificity in gt3 infection was markedly different to that previously described for gt1, confirming that sequence differences between genotypes result in distinct immunological profiles. Previous work from our laboratory demonstrated that, though T cell responses induced by a potent T cell vaccine containing HCV gt1b non-structural regions do target epitopes dominant in natural infection, induced T cells show limited cross-reactivity against other genotypes. In this thesis, it was assessed whether T cells primed in natural gt3 infection are able to recognize viral sequence variants at dominant epitopes, which would make these potential targets in cross-reactive vaccine design. For seven gt3-specific T cell epitopes identified here as dominant, major sequence variability was observed within and between genotypes, and limited T cell cross-reactivity observed against identified viral variants. This suggests that regions frequently targeted in natural infection may not serve as attractive targets for cross-reactive vaccine design. These results informed the subsequent design of a cross-reactive vaccine based on fragments of HCV that are conserved between genotypes. A generic algorithm was developed to define viral regions conserved between major HCV genotypes (for 1a/1b, 1/3a, 1-6), and these were joined to form immunogens between 819 and 1543 AA long. Possible artificial, non-HCV epitopes formed by junctions were identified using online epitope prediction servers, and abrogated through the insertion of 2-6 amino acid linkers. To address the concern that conserved regions may not be immunogenic, epitopes described in natural HCV infection were mapped on HCV sequences, showing that conserved segments are well populated with epitopes; additionally, strong binding peptides were predicted for conserved segments using online epitope prediction programs, suggesting potential in vivo immunogenicity. In conclusion, HCV T cell specificity is distinct between genotypes, with limited T cell cross-reactivity between viral variants. Leading from this result, vaccine immunogens were designed entirely based on conserved viral regions. This work paves the way for future studies of novel HCV immunogens based on conserved viral segments between genotypes
Eleanor McClaugherty with students, Marie Barnes and Bobbie Estes, seated at desk with books
No full text''Sam Houston High School students studying for sixth annual William Randolph Hearst American History contest. Marie Barnes (C), Bobbie Estes (R) with teacher Eleanor McClaugherty. History contest is given Nov. 29 in Thomas Jefferson High School. Five winners will be selected to compete in the national finals and receive savings bonds.'
Dr. Eleanor J. Smith Black History Collection
No full textDoctor Eleanor J. Smith is an African American studies educator, musician, university system chancellor, author, and visual artist. Dr. Smith was faculty member of the University of Cincinnati’s Afro-American Studies Department and William Patterson University. After obtaining a doctorate in African American studies and becoming a university professor, Dr. Smith wrote and directed performances about the Black experience during the 1970s
Letter from Eleanor Roosevelt to Mrs. Mary Tsukamoto, November 24, 1943
No full textTyped correspondence from Eleanor Roosevelt to Mary Tsukamoto thanking her for her letter and inquiring about her future plans. Signed by Eleanor Roosevelt.The Japanese American Archival Collection documents the people, places, and daily life of Japanese Americans, primarily those who lived in the once thriving community of pre-war Florin in the Sacramento region, as well as the conditions in American incarceration camps during World War II. The approximately 7,000 original items include personal and official letters, photographs, diaries, arts and crafts, newsletters, textiles, camps artifacts, yearbooks and other publications
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