52 research outputs found
Benard F. Barnes and Ellis L. Spencer affidavit, 1960 July 8
No full textAffadavit of civil engineers Benard Barnes and Ellis Spencer, describing the distances from the residences of H. H. Kirnon, Josephine Maxey, and James R. Mapp to Orchard Knob School
Benard F. Barnes and Ellis L. Spencer affidavit, 1960 July 8
No full textAffadavit of civil engineers Benard Barnes and Ellis Spencer, describing the distances from the residences of H. H. Kirnon, Josephine Maxey, and James R. Mapp to Orchard Knob School
Moist Rayleigh-Benard Convection
No full textWe report the observations from turbulent thermal Rayleigh-Benard convection experiment with a two-phase liquid-vapor binary mixture. Evaporation/condensation processes in a turbulent convection are accompanied by the formation of cloud like structures above the liquid-vapor interface. We also found that a liquid film condensation on the underside of the top plate results in regular hexagonal patterns of falling droplets
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
Full text linkG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway
Full text linkProstaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma
On the evolution of flow topology in turbulent Rayleigh-Bénard convection
Full text linkCopyright 2016 AIP Publishing. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing.Small-scale dynamics is the spirit of turbulence physics. It implicates many attributes of flow topology evolution, coherent structures, hairpin vorticity dynamics, and mechanism of the kinetic energy cascade. In this work, several dynamical aspects of the small-scale motions have been numerically studied in a framework of Rayleigh-Benard convection (RBC). To do so, direct numerical simulations have been carried out at two Rayleigh numbers Ra = 10(8) and 10(10), inside an air-filled rectangular cell of aspect ratio unity and pi span-wise open-ended distance. As a main feature, the average rate of the invariants of the velocity gradient tensor (Q(G), R-G) has displayed the so-calledPeer ReviewedPostprint (author's final draft
A population-based study of diabetes and its characteristics during the fasting month of ramadan in 13 countries: Results of the epidemiology of diabetes and ramadan 1422-2001 (EPIDIAR) study
No full textOBJECTIVE - The aim of this study was to assess the characteristics and care of patients with diabetes in countries with a sizable Muslim population and to study diabetes features during Ramadan and the effect of fasting. RESEARCH DESIGN AND METHODS - This was a population-based, retrospective, transversal survey conducted in 13 countries. A total of 12,914 patients with diabetes were recruited using a stratified sampling method, and 12,243 were considered for the analysis. RESULTS - Investigators recruited 1,070 (8.7percent) patients with type 1 diabetes and 11,173 (91.3percent) patients with type 2 diabetes. During Ramadan, 42.8percent of patients with type 1 diabetes and 78.7percent with type 2 diabetes fasted for at least 15 days. Less than 50percent of the whole population changed their treatment dose (approximately one-fourth of patients treated with oral antidiabetic drugs [OADs] and one-third of patients using insulin). Severe hypoglycemic episodes were significantly more frequent during Ramadan compared with other months (type 1 diabetes, 0.14 vs. 0.03 episode-month, P = 0.0174; type 2 diabetes, 0.03 vs. 0.004 episode-month, P 0.0001). Severe hypoglycemia was more frequent in subjects who changed their dose of OADs or insulin or modified their level of physical activity. CONCLUSIONS - The large proportion of both type 1 and type 2 diabetic subjects who fast during Ramadan represent a challenge to their physicians. There is a need to provide more intensive education before fasting, to disseminate guidelines, and to propose further studies assessing the impact of fasting on morbidity and mortality.Akanji AO, 2000, EUR J CLIN NUTR, V54, P508, DOI 10.1038-sj.ejcn.1601047; Alwan A, 1992, World Health Stat Q, V45, P355; Mafauzy M, 1990, Med J Malaysia, V45, P14; Azizi F, 1998, INT J RAMADAN FASTIN, V2, P8; Azizi F, 1887, MED J IRI, V1, P38; BAGRAICIK N, 1994, 1 INT C HLTH RAM, P32; BELKHADIR J, 1993, BRIT MED J, V307, P292; BESSAOUD K, 1990, REV EPIDEMIOL SANTE, V38, P91; Bouguerra R, 1997, 2 INT C HLTH RAM, P33; CHEAH JS, 1990, ANN ACAD MED SINGAP, V4, P501; COCKRAM CS, 2000, KONG KONG MED J, V1, P43; DAVIDSON JC, 1979, BRIT MED J, V2, P1511; HAKKOU F, 1994, GASTROENTEROL CLIN B, V3, P190; HAOURI M, 1997, CIRCADIAN EVOLUTION, P31; HGOJLUND K, 2001, AM J PHYSIOL-ENDOC M, V1, pE50; *INT M DIAB RAM RE, 1995, HASS 2 FDN SCI MED R; Jonsson B, 2002, DIABETOLOGIA, V45, pS5, DOI 10.1007-s00125-002-0858-x; Kadiki OA, 1998, DIABETES METAB, V24, P424; Kadiri A, 2001, DIABETES METAB, V27, P482; Katibi I A, 2001, Niger J Med, V10, P132; KHOGHEER Y, 1987, ANN SAUDI MED S, V7, P5; King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337-diacare.21.9.1414; KING H, 1998, DIABETES CARE, V9, P414; KING H, 1993, DIABETES CARE, V16, P157, DOI 10.2337-diacare.16.1.157; MAFAUZY M, 1990, MED J MALAYSIA, V1, P14; NIAZI G, 1997, 2 INT C HLTH RAM, P24; Ramadan J, 1999, NUTRITION, V15, P735, DOI 10.1016-S0899-9007(99)00145-8; Salti IS, 1997, E MEDITERR HLTH J, V3, P462; SATMAN I, 2002, DIABETES CARE, V825, P1551; Scott TG, 1981, KING ABDULAZIZ MED J, V1, P23; Southwell A, 1997, PRACTICAL DIABETES I, V14, P201, DOI 10.1002-pdi.1960140710; Uysal AR, 1998, DIABETES CARE, V21, P2033, DOI 10.2337-diacare.21.11.2033; Yarahmadi Sh, 2003, J Coll Physicians Surg Pak, V13, P32914310210
Radionuclidic purity measurements for cyclotron-produced 99mTc via 100Mo(p,2n) at 18 MeV
No full textNew subgrid-scale models for large-eddy simulation of Rayleigh-Bénard convection
Full text linkPublished under licence in Journal of Physics: Conference Series by IOP Publishing Ltd.
Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.At the crossroad between flow topology analysis and the theory of turbulence, a new eddy-viscosity model for Large-eddy simulation has been recently proposed by Trias et al.[PoF, 27, 065103 (2015)]. The S3PQR-model has the proper cubic near-wall behaviour and no intrinsic limitations for statistically inhomogeneous flows. In this work, the new model has been tested for an air turbulent Rayleigh-Benard convection in a rectangular cell of aspect ratio unity and n span-wise open-ended distance. To do so, direct numerical simulation has been carried out at two Rayleigh numbers Ra = 108 and 1010, to assess the model performance and investigate a priori the effect of the turbulent Prandtl number. Using an approximate formula based on the Taylor series expansion, the turbulent Prandtl number has been calculated and revealed a constant and Ra-independent value across the bulk region equals to 0.55. It is found that the turbulent components of eddy-viscosity and eddy-diffusivity are positively prevalent to maintain a turbulent wind essentially driven by the mean buoyant force at the sidewalls. On the other hand, the new eddy-viscosity model is preliminary tested for the case of Ra = 108 and showed overestimation of heat flux within the boundary layer but fairly good prediction of turbulent kinetics at this moderate turbulent flow.Peer ReviewedPostprint (published version
The role of Umkhonto we Sizwe (MK) in the national liberation struggle in South Africa with reference to the rural far northern Transvaal, 1976-1990
No full textIncludes bibliographical references (leaves 250-275)
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