325 research outputs found
Public health modernization assessment report
No full textThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on July 13, 2016).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Müteselsil borçlulukta borçlulardan birinin ibra edilmesinin diğerlerine etkisine ilişkin TBK m. 166 f.3 hükmünün değerlendirilmesi
No full textKadir Berk Kapancı (MEF Author)##nofulltext##..
Ou va l'arbitrage de groupe dans l'arbitrage international
No full text##nofulltext##Kadir Berk Kapancı (MEF Author)..
Ahlaka aykırı bir fiille kasten verilen zararın tazmini (TBK 49 II)
No full text##nofulltext##Kadir Berk Kapancı (MEF Author)..
Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives
No full textSAHIN, ZAFER/0000-0002-5976-676X; Berk, Barkin/0000-0001-6047-2796WOS: 000484830900001PubMed: 31475759The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. in addition, thiosemicarbazones are among the most potent and well-known ribonucleotide reductase inhibitors. in this study, 24 new thiosemicarbazone derivatives were synthesized, and the structures and purity of the compounds were determined by IR, H-1 NMR, C-13 NMR, mass spectroscopy, and elemental analysis. the IC50 values of these 24 compounds were determined with an assay for ribonucleotide reductase inhibition. Compounds 19, 20, and 24 inhibited ribonucleotide reductase enzyme activity at a higher level than metisazone as standard. the cytotoxic effects of these compounds were measured on the MCF7 (human breast adenocarcinoma) and HEK293 (human embryonic kidney) cell lines. Similarly, compounds 19, 20, and 24 had a selective effect on the MCF7 and HEK293 cell lines, killing more cancer cells than cisplatin as standard. the compounds (especially 19, 20, and 24 as the most active ones) were then subjected to docking experiments to identify the probable interactions between the ligands and the enzyme active site. the complex formation was shown qualitatively. the ADME (absorption, distribution, metabolism, and excretion) properties of the compounds were analyzed using in-silico techniques.Anadolu University Scientific Research Projects CommissionAnadolu University [1609S624]Anadolu University Scientific Research Projects Commission, Grant/Award Number: 1609S62
Acemetacin in Acute and Chronic Pain Management
No full textAcemetacin is the carboxymethyl ester of indomethacin and is a pro-drug precursor compound, in other words, a prodrug. The pharmacologically active metabolite of acemetacin is also indomethacin. Acemetacin exerts its potent non-steroidal anti-inflammatory effects in the body as indomethacin. It is known that acemetacin is not only a prodrug of indomethacin, but also an agent with gastric protective mechanisms, possibly involving a reduction in leukocyte adhesion, and that acemetacin exerts gastric protective effects by exhibiting less efficacy on the COX-1 enzyme in the gastric mucosa compared to direct indomethacin use. It is clear that acemetacin is a valuable NSAID for acute and chronic pain.
Keywords: Acemetacin, indomethacin, non-steroidal anti-inflammatory drugs
Corrigendum: Anemia detection through non-invasive analysis of lip mucosa images
No full textIn the published article, there was an error in the author list. The new requested author order is: Shekhar Mahmud1, Turker Berk Donmez2, Mohammed Mansour3*, Mustafa Kutlu3 and Chris Freeman41 Department of Systems Engineering, Military Technological College, Muscat, Oman 2 Department of Biomedical Engineering, Sakarya University of Applied Sciences, Serdivan, Sakarya, Türkiye 3 Department of Mechatronics Engineering, Sakarya University of Applied Sciences, Serdivan, Sakarya, Türkiye 4 Electronics and Computer Sciences, University of Southampton, Southampton, United Kingdom The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. Copyright © 2023 Mahmud, Donmez, Mansour, Kutlu and Freeman
De kosten van een zandsuppletie op het strand van de Kop van Goeree uitgevoerd met behulp van de zogenaamde "Punaise"
No full textIn het 1e deel van het afstudeerverslag van A.H. van Berk (lit. 1) werd de vraag gesteld of een baggersysteem voor het kustonderhoud van de Kop van Goeree met de punaise (fig. 0) in één van de wingebieden A, B of C (fig. 2) kan konkurreren met een systeem met een cutterzuiger in wingebied E. Voor het antwoord op deze vraag zijn de kosten van zowel de uitvoering met de punaise als die met de cutterzuiger bepaald. Deze kosten zijn omgerekend naar de gemiddelde jaarlijkse kosten voor het kustonderhoud en onderling vergeleken. In het tweede deel wordt een handleiding gegeven voor de berekening van de jaarlijkse kosten van het kustonderhoud van de lop van Goeree door zandsuppietie a.b.v. de Punaise.Hydraulic EngineeringCivil Engineering and Geoscience
A review on the berk journal that belongs to ara nesil
No full textBerk, Mehmed Remzî tarafından 1886-1887 yıllarında, İstanbul'da 12 sayı yayımlanmış edebiyat ve ilim mecmuasıdır. Şiir, hikâye, mektup, edebî tenkit ve hâl tercümesi (biyografi) türlerinde eserleri ihtiva eden mecmuada; fen, din, müzik ve tarih konularında ilmî yazılar da bulunmaktadır. Bunun yanında Alman, Fransız, İngiliz, Yunan yazar ve şairlerin eserlerinden yapılmış tercümeler vasıtası ile Batı edebiyatından örnekler okuyucuya sunulmuştur. Türk dergiciliğinin gelişmesinde önemli bir yere sahip olan Berk'te Alaybeyizâde Nâcî, Halit Ziyâ Uşaklıgil, Muallim Nâcî, Nâbîzâde Nâzım, Tevfîk Fikret gibi edebiyat tarihimizde önem arz eden yazar ve şairlerin eserleri bulunmaktadır. .Bunun yanında Berk'in yayımlandığı tarihlerin içinde bulunduğu dönem edebiyat tarihimizde Ara Nesil olarak adlandırılmakta ve bu dönemin sanatçılarından İbn'ur-reşad Ali Ferruh, Harputlu Hayrî, Muallim Feyzî, Mehmet Zîver, Şeyh Vasfî, Recep Vahyî, Nâbîzâde Nâzım, Abdülhekim Sabit, Alaybeyizâde Nâci, Ali Kemâl, Ali Ulvî, Besîm, Halîl Edîb, Hayret Efendi, Mehmed Reşîd ve Menemenlizâde Mehmed Tâhir gibi sanatçıların eserleri de mecmuada yer almaktadır. Yüksek lisans tezi olarak hazırlanan bu çalışmayı Berk'in tanıtılması, yeni yazıya aktarılması, biçim ve içerik yönünden incelenmesi, yazar kadrosu hakkına bilgi verilmesi ve detaylı fihristlerinin çıkarılması hususları doğrultusunda hazırlayarak Berk'in, Türk dergiciliği ve edebiyatı içerisindeki konumunu tespit etmeyi amaçladık.Berk is a literary and science journal that was published 12 sections by Mehmed Remzî 1886-1887 in İstanbul. The journal has different genres of work that poetry, stories, letters, literary criticisms and biographies. İt also includes scientific essays about science, religion, music and history. The examples of the Western literature beside that had been offered to the reader by the translation of the German, French, English and Greek author's work. İn the Berk journal which has an important place in the development of Turkish journalism has the works of writers and poets such as Alaybeyizâde Nâcî, Halit Ziyâ Uşaklıgil, Muallim Nâcî, Nâbîzâde Nâzım, Tevfîk Fikret which have an important place in our history of literature. İn addition the perrod in which ibcludes the dates that Berk journal is published is called "Ara Nesil" in our literary history and the works of authors such as İbn'ur-reşad Ali Ferruh, Harputlu Hayrî, Muallim Feyzî, Mehmet Zîver, Şeyh Vasfî, Recep Vahyî, Nâbîzâde Nâzım, Abdülhekim Sabit, Alaybeyizâde Nâci, Ali Kemâl, Ali Ulvî, Besîm, Halîl Edîb, Hayret Efendi, Mehmed Reşîd, Menemenlizâde Mehmed Tâhir also featured in the journal. We aimed in this work to determine the position of Berk journal in the Turkish journalism and literature by introducing Berk journal, transferring it to a new writing, analyzing it in terms of form and content, giving information about the staff and preparing detailed indexes
Conflict-based negotiation strategy for human-agent negotiation
No full textDay by day, human-agent negotiation becomes more and more vital to reach a socially beneficial agreement when stakeholders need to make a joint decision together. Developing agents who understand not only human preferences but also attitudes is a significant prerequisite for this kind of interaction. Studies on opponent modeling are predominantly based on automated negotiation and may yield good predictions after exchanging hundreds of offers. However, this is not the case in human-agent negotiation in which the total number of rounds does not usually exceed tens. For this reason, an opponent model technique is needed to extract the maximum information gained with limited interaction. This study presents a conflict-based opponent modeling technique and compares its prediction performance with the well-known approaches in human-agent and automated negotiation experimental settings. According to the results of human-agent studies, the proposed model outpr erforms them despite the diversity of participants’ negotiation behaviors. Besides, the conflict-based opponent model estimates the entire bid space much more successfully than its competitors in automated negotiation sessions when a small portion of the outcome space was explored. This study may contribute to developing agents that can perceive their human counterparts’ preferences and behaviors more accurately, acting cooperatively and reaching an admissible settlement for joint interests.Interactive Intelligenc
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