6 research outputs found
Knowledge of Brazilian higher education students about academic plagiarism
Full text linkO presente estudo visa analisar publicações que mostram o conhecimento de estudantes brasileiros de ensino superior sobre plágio, demonstrando o papel das instituições de ensino superior frente ao plágio acadêmico. Essa problemática surge com a globalização da rede mundial de computadores e a facilidade de acesso à informação. Trata-se de um estudo bibliográfico-descritivo, em que utilizou-se as bases de dados Scielo e Periódico CAPES para seleção das publicações. O tipo de estudo, população amostral, ferramenta de coleta de dados, questões empregadas nos questionários e resultados mais relevantes constituíram as variantes meditadas. A partir da análise, observou-se que existe uma maior similaridade de dados entre os artigos. Além disso, a maior parte dos estudantes demonstra não ter conhecimento suficiente sobre o tema e a lei que o rege, e que a Internet é a ferramenta mais usada para fazer trabalhos acadêmicos. Portanto, as informações aqui reunidas podem suscitar novos estudos a fim de elucidar a realidade desse tipo de infração nas instituições de ensino no Brasil.The present study aims to analyze studies which show the knowledge of the Brazilian higher education students about plagiarism, demonstrating the role higher education institutions play in the face of academic plagiarism. This issue arises because of the globalization of Internet and the easy access to information. It is a bibliographic-descriptive study in which Scielo and Periódico CAPES were used as database to select publications. The type of study, sample population, data collection tool, questions used in the questionnaires and the most relevant results constituted the meditated variants. It shows that there is a greater data similarity among the articles. In addition, most students demonstrate they do not have enough knowledge about plagiarism and its law, and Internet is the most widely used tool among them for doing academic work. Thus, the information gathered here may raise new studies in order to elucidate the reality of this crime in educational institutions in Brazil
Plumeria species: a review of morphology, traditional uses, phytochemicals, and pharmacological activities
No full text882-897Plants from genus Plumeria belong to the Apocynaceae family and are considered native to the New World. These plants are commonly found in tropical and subtropical areas around the world. Plumerias are well known for their ornamental value and especially as medicinal agents. Species from this genus have played a crucial role in the popular herbal medicine as well as in alternative and complementary system of medicine. This review collects and updates information about Plumeria species. The article highlights findings and explores the medicinal status of these plants with their biological properties and phytochemical components suggested by describing several studies with in vitro and in vivo evaluations. Our review emphasizes the potential beneficial effects of Plumerias for human and provides evidence that this genus can be used as source for drug development in future
Evaluation of the podoplanin/C-type lectin-like receptor-2 (CLEC-2) pathway as a mediator of platelet and coagulation activation in sickle cell disease
No full textBackground: Sickle cell disease (SCD) is a condition characterized by a prothrombotic state attributed to the simultaneous activation of hemostasis and innate immunity, referred to as thromboinflammation. Previous studies have demonstrated that the podoplanin (PDPN)/C-type lectin-like receptor-2 (CLEC-2) pathway is an emerging and important element of the pathogenesis of conditions in which inflammation and thrombosis coexist, but no data is available regarding its role in SCD. Objectives: To explore the PDPN/CLEC-2 pathway in SCD and correlate it with parameters of disease severity. Methods: Fifty SCD patients (35 with SS genotype; 15 with SC genotype) and 25 healthy individuals were recruited. PDPN and CLEC-2 were assessed for both soluble and surface expression on cells and cell aggregates, along with other classical parameters of hemostasis and platelet activation. An in vitro study was performed to analyze the effect of anti-PDPN antibody on the formation of monocyte–platelet aggregates. Results: Circulating levels and expression of PDPN and CLEC-2 were higher in patients with SCD, particularly in those with genotype SS. The number of CD41+CLEC+ monocytes correlated with hemoglobin, D-dimer, von Willebrand factor, and PDPN+ monocytes. In vitro, PDPN blockade reduced both monocyte–platelet aggregate formation and platelet activation. Finally, patients with a history of vaso-occlusive crises presented a trend toward increased PDPN expression in monocytes (P = .06). Conclusion: Our findings suggest that the PDPN/CLEC-2 pathway may play an important role in the pathogenesis of thromboinflammation in SCD, especially in patients with the SS genotype
Angiopoietin2 is associated with coagulation activation and tissue factor expression in extracellular vesicles in COVID-19
Full text linkCoagulation activation in immunothrombosis involves various pathways distinct from classical hemostasis, offering potential therapeutic targets to control inflammation-induced hypercoagulability while potentially sparing hemostasis. The Angiopoietin/Tie2 pathway, previously linked to embryonic angiogenesis and sepsis-related endothelial barrier regulation, was recently associated with coagulation activation in sepsis and COVID-19. This study explores the connection between key mediators of the Angiopoietin/Tie2 pathway and coagulation activation. The study included COVID-19 patients with hypoxia and healthy controls. Blood samples were processed to obtain platelet-free plasma, and frozen until analysis. Extracellular vesicles (EVs) in plasma were characterized and quantified using flow cytometry, and their tissue factor (TF) procoagulant activity was measured using a kinetic chromogenic method. Several markers of hemostasis were assessed. Levels of ANGPT1, ANGPT2, and soluble Tie2 correlated with markers of coagulation and platelet activation. EVs from platelets and endothelial cells were increased in COVID-19 patients, and a significant increase in TF + EVs derived from endothelial cells was observed. In addition, ANGPT2 levels were associated with TF expression and activity in EVs. In conclusion, we provide further evidence for the involvement of the Angiopoietin/Tie2 pathway in the coagulopathy of COVID-19 mediated in part by release of EVs as a potential source of TF activity
Angiopoietin2 is associated with coagulation activation and tissue factor expression in extracellular vesicles in COVID-19
Full text linkCoagulation activation in immunothrombosis involves various pathways distinct from classical hemostasis, offering potential therapeutic targets to control inflammation-induced hypercoagulability while potentially sparing hemostasis. The Angiopoietin/Tie2 pathway, previously linked to embryonic angiogenesis and sepsis-related endothelial barrier regulation, was recently associated with coagulation activation in sepsis and COVID-19. This study explores the connection between key mediators of the Angiopoietin/Tie2 pathway and coagulation activation. The study included COVID-19 patients with hypoxia and healthy controls. Blood samples were processed to obtain platelet-free plasma, and frozen until analysis. Extracellular vesicles (EVs) in plasma were characterized and quantified using flow cytometry, and their tissue factor (TF) procoagulant activity was measured using a kinetic chromogenic method. Several markers of hemostasis were assessed. Levels of ANGPT1, ANGPT2, and soluble Tie2 correlated with markers of coagulation and platelet activation. EVs from platelets and endothelial cells were increased in COVID-19 patients, and a significant increase in TF+ EVs derived from endothelial cells was observed. In addition, ANGPT2 levels were associated with TF expression and activity in EVs. In conclusion, we provide further evidence for the involvement of the Angiopoietin/Tie2 pathway in the coagulopathy of COVID-19 mediated in part by release of EVs as a potential source of TF activity
Plumeria species: a review of morphology, traditional uses, phytochemicals, and pharmacological activities
Full text linkPlants from genus Plumeria belong to the Apocynaceae family and are considered native to the New World. These plants are commonly found in tropical and subtropical areas around the world. Plumerias are well known for their ornamental value and especially as medicinal agents. Species from this genus have played a crucial role in the popular herbal medicine as well as in alternative and complementary system of medicine. This review collects and updates information about Plumeria species. The article highlights findings and explores the medicinal status of these plants with their biological properties and phytochemical components suggested by describing several studies with in vitro and in vivo evaluations. Our review emphasizes the potential beneficial effects of Plumerias for human and provides evidence that this genus can be used as source for drug development in future
