1,722,376 research outputs found
BARBIERI M., DE VIVO B., PERRONE V. & TURCO E. (1984) — Strontium geochemistry of the San Donato Unit barite mineralization (Calabria; Italy).
No full textOn the number of fixed edges of automorphisms of vertex-transitive graphs of small valency
Full text linkWe prove that, if Γ is a finite connected 3-valent vertex-transitive, or 4-valent vertex- and edge-transitive graph, then either Γ is part of a well-understood family of graphs, or every non-identity automorphism of Γ fixes at most 1/3 of the edges. This answers a question proposed by Primož Potočnik and the third author
La nuova disciplina sostanziale del licenziamento individuale: prime risposte giurisprudenziali
No full textRassegna della prima giurisprudenza in applicazione della nuova disciplina dei licenziamenti individuali contenuta nella L. 92/201
On the order of semiregular automorphisms of cubic vertex-transitive graphs
Full text linkWe prove that, if P is a finite connected cubic vertex-transitive graph, then either there exists a semiregular automorphism of P of order at least 6, or the number of vertices of P is bounded above by an absolute constant. (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
A new pleiotropic effect of statins in elderly: Modulation of telomerase activity
No full textRecent evidence suggests a link between statins and telomere biology. Whether statin treatment may modulate telomerase activity and affect telomere erosion rate is unknown. We aimed at investigating the potential impact of statin therapy on peripheral blood mononuclear cells telomerase activity, its implication on LTL variability, and its association with telomere shortening rates along with aging. The cross-sectional study was conducted in 230 subjects (age range: 30-86 y) stratified according to statins treatment. LTL was measured by quantitative polymerase chain reaction and telomerase activity by a PCRELISA protocol. Subjects on statin treatment showed higher telomerase activity (P<0.0001) and longer LTL (P=0.028) levels compared to the nonstatin group. Statin therapy was associated with higher telomerase activity independently of multiple covariates, including age, gender, smoking habits, lipid, systemic inflammation, glucose, and blood pressure levels (P=0.019). Indeed, subjects on statin treatment showed significant lower telomere erosion along with aging. Every 1 y increment in age, LTL decreases by 0.058 Kb in no statin and 0.033 Kb in statin groups, respectively, as well as the major difference in telomere attrition between groups was found after the age of 65 yr (P<0.0001). In summary, statins, modulating telomerase activity, affect telomere erosion along with aging.-Boccardi, V., Barbieri, M., Rizzo, M. R., Marfella, R., Esposito, A., Marano, L., Paolisso, G. A new pleiotropic effect of statins in elderly: modulation of telomerase activit
Editorial: Groundwater salinity: origin, impact, and potential remedial measures and management solutions
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Analyzing Patent-Literature for Mapping and Evaluating Covid-19 Innovation
No full textThe Covid-19 pandemic has prompted several patent offices worldwide to provide companies and investigators with a large number of new web-based services to cope with logistical and financial problems related to patent proceedings and to foster research and access to information relevant for developing new, more appropriate products and technologies. As of spring 2021, it is still too early to have a complete view about if and how innovation stemming from this “new normal” situation has been captured and claimed in patent applications. Given the potential financial and strategic importance for some applicants to get a patent quickly granted, the examination and publication of patent applications claiming products and technologies related to Covid-19 may have been accelerated shortly after their filing, at least in some countries. The paper present the data that has been extracted from patent databases using a methodology described in a recent publication (Falciola L and Barbieri M, “Searching and Analyzing Patent-Relevant Information for Evaluating COVID-19 Innovation”; Falciola L and Barbieri M, “Searching and Analyzing Patent-Relevant Information for Evaluating COVID-19 Innovation”; posted on Jan. 26th, 2021; available at SSRN: https://ssrn.com/abstract=3771756) about the earliest patent literature explicitly mentioning the relevance of claimed subject matter for Covid-19 pandemic that has been published by major patent offices worldwide. This analysis has been performed in three main dimensions: the claimed technologies (in medical and other domains), the type of patent proceedings (as a regular patent application or utility models, already granted or not), and countries (having own medical, IP, and economic policies). The patent publication trends have also been studied by distinguishing between two periods (March 2020 - August 2020 and September 2020 - February 2021) to identify how the temporal evolution of the Covid-19 pandemic may have affected the patenting strategies for protecting innovation in an emergency, as some evidence would suggest
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