1,720,963 research outputs found
Determinazione del testosterone libero plasmatico mediante ultrafiltrazione e successivo dosaggio radioimmunologico.
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L'uso dell'ultrafiltrazione nella determinazione degli steroidi liberi plasmatici.
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Quality assurance system using ISO 9000 series standards to improve the effectiveness and efficacy of the Headache Centre
No full textThe need to improve the quality of patient care is becoming extremely important considering the high prevalence, social and personal impact of headache disorders in the population at large. We describe implementation of International Organization for Standardization (ISO) 9000 quality assurance standards to improve the organization and the quality of medical care provided by an Italian Headache Center.
Standards of care have been defined and explicitated to patients, general pratictioners and consultant collegues. Adherence to standards was monitored. The process of care provided by the headache center were evaluated and riorganized within the multispecialty department of the hospital and between general pratictioners who generally refer patients. Most risky activities were procedured. Criteria for shortening waiting list were defined in such a way that a general pratictioner should be able to refer a patients accordingly a priority of different urgency. Availability and convenience of specialists for consultations and facilities for diagnostic testing were planned also for outpatients. Teaching course for general pratictioners dedicated to the main issues in headache diagnosis and treatment had been programmed. Patients satisfaction was periodically monitored by a self report questionairre
Estimation of instantaneous secretory rate of luteinizing hormone in women during the menstrual cycle and in men.
No full textIn both men and women the pulsatile secretory pattern of LH has been extensively characterized. In the present study we used the algorithm for computation of instantaneous secretory rate (ISR) incorporated into the DETECT program to evaluate the secretory activity of gonadotrophs in vivo. We studied the pulsatile release of LH in four healthy women during four phases of the same menstrual cycle (early and late follicular and luteal phases) and in five healthy men. Computation of ISR permitted us to estimate the frequency and the duration of the secretory events from the gonadotrophs. Samples were collected every 10 min for 6 h. The apparent LH pulsatile frequency during the menstrual cycle varied from 5.0 +/- 0.8 (mean +/- SD) during the early follicular phase (EFP) to 5.3 +/- 1.2 peaks/6h during the late follicular phase (LFP), to 3.3 +/- 1.0 during early luteal phase (ELP) and to 5.3 +/- 0.4 peaks/6h during the late luteal phase (LLP). The mean pulse duration also changed throughout the phases of the cycle (EFP 47.4 +/- 13.2 min; LFP 55.4 +/- 21.6 min; ELP 100 +/- 50.4 min; LLP 48.1 +/- 11 min). In healthy men the LH pulse frequency was 3.8 +/- 1.6 peaks/6h and the duration was 71.5 +/- 35.7 min. When time series were analysed for ISR determination no significant changes were observed between the LH pulse frequency detected on ISR and that observed on plasma concentrations. Conversely, a significant reduction of the duration of the pulses was found when using ISR instead of plasma concentration
Biologically active luteinizing hormone (LH) in Klinefelter's syndrome: response to gonadotropin releasing hormone (GnRH) and effects of testosterone undecanoate.
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Twenty-four-hour pattern of plasma SHBG, total proteins and testosterone in young and elderly men.
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Daily rhythmicity of testosterone production by "in vitro" LH stimulated mouse Leydig cells.
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Age-related changes in plasma dehydroepiandrosterone sulphate, cortisol, testosterone and free testosterone circadian rhythms in adult men.
No full textThe circadian rhythms of serum luteinizing hormone, follicle-stimulating hormone, testosterone (T), free testosterone (fT), sex hormone-binding globulin (SHBG), oestradiol, cortisol and dehydroepiandrosterone sulphate (DHA-s) have been investigated in 5 normal male adults and 6 elderly men. Circadian rhythms were detected statistically significant (p less than 0.05) by population mean cosinor analysis, for T, fT, cortisol and DHA-s in the young group. In the elderly population, serum cortisol showed a clear circadian rhythm, although with some phase modification, whereas DHA-s secretion lost its circadian rhythmicity. This demonstrates that ageing differently affects the two major adrenal functions, glucocorticoid and androgenic; further, the data suggest that an independent adrenal androgen-regulating system could be selectively impaired in the older subjects. In the elderly group the loss of T circadian rhythm was confirmed, but a statistically significant circadian rhythm of fT was recorded. It was characterized by a marked phase advance and not related with the SHBG modifications found in elderly men. This finding leads us to reconsider the role of fT, which appears more sensitive than total T, in studying circadian rhythm of gonadal androgen secretion
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