39 research outputs found
Benzodithiophene and benzotrithiophene as Ï cores for two-and three-blade propeller-shaped ferrocenyl-based conjugated systems
No full textThe syntheses of linear and star-shaped bis- and tris(ferrocenyl) derivatives of benzo[1,2-b:4,5-b′]dithiophene and benzo[1,2-b:3,4-b′:5,6-b′′]trithiophene are achieved through one-pot CuI/TMEDA-catalyzed (TMEDA = tetramethylethylenediamine) multiple annulations of bromoethynylbenzenes with sodium sulfide. In addition, the preparation of the parent benzotrithiophene in a good yield with a short reaction time is achieved through the threefold annulation of 1,3,5-trifluoro- Introduction Benzo[b]thiophene (BT, Scheme 1) and its derivatives are an important class of fused thiophene compounds owing to their wide range of biological properties[1,2] and various applications in materials science.[3] Scheme 1. Fused thiophene compounds: benzo[b]thiophene (BT), benzo- [1,2-b:4,5-b′]dithiophene (BDT), and benzo[1,2-b:3,4-b′:5,6-b′′]trithiophene (BTT). In particular, (multi)thiophene fused aromatic compounds are attracting interest as promising electronic materials for organic conductors,[4] organic light-emitting diodes,[5] photovoltaic cells,[6] and field-effect transistors.[7] For this reason, thiophene- based π-conjugated oligomers have been investigated widely as organic semiconductors.[8] Recently, much effort has been focused on benzo[1,2-b:4,5-b′]- dithiophene (BDT) and benzo[1,2-b:3,4-b′:5,6-b′′]trithiophene (BTT, Scheme 1) as potential π cores for a new class of organic semiconductors as they contain two or three identical thiophene moieties with C2h or C3h symmetries that enable twoand three-dimensional molecular extensions. [a] Department of Chemical Sciences, University of Padova Via Marzolo 1, 35131 Padova, Italy E-mail: [email protected] http://www.chimica.unipd.it/ Supporting information and ORCID(s) from the author(s) for this article are available on the WWW under https://doi.org/10.1002/ejoc.201701045. Eur. J. Org. Chem. 2017, 5966–5974 5966 © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 2,4,6-tris(trimethylsilyl)ethynylbenzene. The computed structural and electronic features of these ferrocenyl derivatives as well as their UV/Vis spectra and electrochemistry are discussed, and the results provide insights into the effect of the presence of three rather than two ferrocenyl units. To the best of our knowledge, 2,5,8-tris(ferrocenyl)benzo[1,2-b;3,4-b′;5,6-b′′]trithiophene is the first organometallic complex containing benzotrithiophene
Semaglutide vs Liraglutide for Weight Loss in Adults with Obesity
No full textIntroduction: Obesity is a growing chronic condition worldwide with limited effective and safe treatment options. Semaglutide and liraglutide are two GLP-1a medications with encouraging outcomes for the treatment of obesity. The purpose of this paper is to compare semaglutide to liraglutide for weight loss and obesity
Methods: Pubmed was searched for randomized controlled trials, systematic reviews, and meta- analyses from 2019 to 2024 to assess efficacy of semaglutide and liraglutide. Five articles were selected for clinical review.
Results: In 4 out of the 5 studies there was a greater reduction in weight in patients receiving semaglutide compared to liraglutide. Statistically significant improvements in HbA1c were noted in patients taking semaglutide. Most common adverse effects were gastrointestinal issues, which were noted with both semaglutide and liraglutide treatments.
Discussion: Studies suggest that semaglutide may be more effective in promoting weight loss as compared to liraglutide. Further research is needed to determine long-term effects of semaglutide for weight loss
The present study attempts to briefly depict the splendid era of BABATAHER-E-ORIAN
No full text1 - Introduction of BABATAHER and analysis of Erfan and in the fifth century; the latter itself is comprrisedof three sections: a) The concept of Erfan as well as the differences existing between Erfan and Sufism. b) Erfan a most private personal knowledge, intransferable to others. c) A perspective of "Ertan" and "sufism" in the second century along with some dicriptions. - Introduction of BABATAHER-E-ORIAN and a number of his This section, too, is comprised of l\VO sections: a) Introducing those who bclivcd in four eminent figures from this school and some of their most brilliant works. b) The author has contented himself to introducing four celebrities from this school. - General conclusion on the basis of mystical methods. This is divied into two parts: in part a some of the beliefs of the four mystics mentioned above arc pointdc out, analying the concept of piosity as well as the positive and the negative aspects of worship ans religious devotion. In part b some of the most glorious works of those four mystics who belong the same school arc pointed out. At the end a conclusion is provided concerning the pioneers of this school and the method they had adopted in their practice. Generally speaking, in this section the worldviews of these pioneers are introduced by referring to their works; attempts have been made to prove that these grest people saw nothing but God in the world. Attempts have also been made to prove their vicwpionts and hence their optimism and beliefs in existenc
Enhanced Nanocellulose Production from Cotton and Textile Waste Using Binary and Ternary Natural Deep Eutectic Solvents
No full textThe growing accumulation of textile waste poses significant environmental challenges, as only a small percentage of materials is currently recycled. However, cotton waste offers a valuable feedstock for the regeneration of cellulose and nanocellulose (NC). This study presents a sustainable and efficient method for producing NC from textile waste using both binary and ternary natural deep eutectic solvents (NADESs). By treating cotton wool, pre-consumer standard cotton fabrics, and post-consumer denim textiles, with NADESs, NC generation is achieved in high yields (up to ≈90%) in all cases. The most promising NADESs, composed of choline chloride and gallic acid (and tartaric acid), effectively dissolve cotton-based materials when subjected to heating and sonication, producing cellulose nanocrystals with length ranging from 100 to 300 nm and crystallinity level up to ≈80%. The NADESs are characterized by thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FT-IR), as well as modeled by density functional theory (DFT), to investigate their hydrogen bond network. Eventually, their recyclability is also investigated. This approach opens promising applications in the fields of sustainable nanomaterial production and textile recycling, providing a greener alternative for waste valorization and promoting circular economy practices. © 2024 The Author(s). Advanced Sustainable Systems published by Wiley-VCH GmbH
Povești „vechi” în haine „noi” – o lectură a romanului Cruciada copiilor de Florina Ilis
No full textFocusing on the success of Florina Ilis’ novel The children’s crusade, this article explores its potential as a literary contribution in a broader global discourse, as it could be considered “literary Romanian capital” in a discussion about world literature. While the book draws on clichéd stereotypes of Romanian society from the early 2000s, including the Ceaușescu era and the challenging transition from communism to democracy, the author uses a universal language of trauma. This allows for a wider audience to engage with the themes presented in the novel. Thus, her story becomes part of a global collection of works exploring the theme of the “children’s crusade” (including George Zabriskie Gray, Marcel Schwob, Lucian Blaga, Jerzy Andrzejewski, Thea Beckman, Gregory J. Rinaldi, Karleen Bradford, Kathleen McDonnell, Bryce Courtenay, Mario Vargas Llosa, Tullio Avoledo, amongst others). Considering the connection between continuity and innovation in Romanian literature, 75 years following Lucian Blaga’s play, with the same title, Florina Ilis employs a plot with medieval roots in her novel, which has fascinated writers worldwide, to deliver a unique perspective, in a new discourse
Gardner-Webb Physician Assistant Students Selected for Highly Competitive Clinical Rotation
No full textTwo students in the Gardner-Webb University Department of Physician Assistant (PA) Studies have been selected to participate in a fall elective clinical rotation at MD Anderson Cancer Center-Texas Medical Center, Houston. Through a highly-competitive process, Taylor Jernigan and Orian Bar, from the GWU Class of 2025, are among only 25 students from across the United States invited to train at this facility. Additionally, the Gardner-Webb students were offered a five-week clinical rotation instead of the usual three to four weeks.https://digitalcommons.gardner-webb.edu/gardner-webb-newscenter-archive/3845/thumbnail.jp
GSH, but not GSSG, specifically decreases ABCB10 ATP binding activity.
No full text<p>A representative autoradiography image and the quantification shown in the bar graph demonstrate that GSH decreased [α-<sup>32</sup>P] 8-azido-ATP signal in ABCB10 from SMPs in a dose dependent manner, whereas GSSG did not. Bar graphs represent mean ± SD from independent experiments.</p
d-Amino-levulinic acid (d-ALA) does not alter 8-azido-ATP-[γ]-biotin photolabeling in ABCB10, whereas GSH and GSSG do.
No full text<p>A) Increasing concentrations of delta-aminolevulinic acid (d-ALA) did not change the photolabeling of ABCB10 by 8-azido-ATP [γ] biotin. Representative Western blot analyses are shown. The bar graph shows the relative intensity of ExtrAvidin-HRP as mean ± SD of independent experiments. B) and C) Increasing concentrations of GSH or GSSG decreased the biotin signal during the photolabeling of ABCB10 by 8-azido-ATP [γ] biotin. The bar graph shows the relative ExtrAvidin-HRP signal. Three independent experiments were conducted and data are shown as mean ± SEM. *p<0.05 vs. signal in 0mM GSH or GSSG treatment.</p
