13,246 research outputs found
A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation
No full textThe human gastrointestinal tract hosts a complex and dynamic community of microorganisms known as the gut microbiota, which play a pivotal role in numerous physiological processes, including digestion, metabolism, and immune function. Recent research has highlighted the significant impact of diet on the gut microbiota composition and functionality, and the consequential effects on host health. Concurrently, there is growing evidence linking the gut microbiota to inflammation, a key factor in many chronic diseases such as inflammatory bowel disease (IBD), obesity, diabetes, and cardiovascular diseases (CVDs). This review explores how dietary components influence the gut microbiota composition, how these microbial changes affect inflammatory pathways, and the therapeutic implications of modulating this axis for chronic inflammatory disease prevention and management. Beneficial dietary patterns, such as the Mediterranean diet (MD) and plant-based diets, promote a diverse and balanced gut microbiota composition, supporting anti-inflammatory pathways. Conversely, the Western diet (WD), high in saturated fats and refined sugars, is associated with dysbiosis and increased inflammation. With all the links between the three variables considered, this review attempts to offer a thorough examination of the triangle formed by inflammation, the gut microbiota, and food
A Comprehensive Review of the Triangular Relationship Among Diet, Gut Microbiota, and Aging
No full textAging is a complex biological process influenced by internal and external factors, with diet and gut microbiota emerging as pivotal, interconnected modulators. This review explores their triangular relationship, emphasizing how they dynamically interact to shape health across the lifespan. Aging involves notable shifts in gut microbiota, including reduced diversity, increased pro-inflammatory taxa, and impaired production of key metabolites, like short-chain fatty acids. These changes contribute to systemic inflammation, immune-senescence, and age-related conditions, such as cognitive decline and metabolic disorders. Diet, particularly Mediterranean and plant-based patterns, plays a critical role in modulating gut microbiota by enhancing beneficial microbes and their metabolic functions. In contrast, Western-style diets rich in saturated fats and processed foods promote dysbiosis and accelerate aging. The review synthesizes evidence from human studies, animal models, and interventions to show how microbiota mediates diet-driven effects on aging. It also explores the role of specific nutrients, fiber, omega-3 fatty acids, and polyphenols in influencing microbial and host aging biology. Emerging therapies, including probiotics, prebiotics, and precision nutrition, show promise for promoting healthy aging by restoring microbial balance. However, gaps remain, including the need for long-term, age-specific studies, standardized microbiome protocols, and integrated omics approaches to support targeted longevity strategies
sj-tif-2-iji-10.1177_20587384211065893 – Supplemental Material for Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma
No full textSupplemental Material, sj-tif-2-iji-10.1177_20587384211065893 for Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma by Chenfeng Wang, Yan Huang, Xin Ma, Baojun Wang and Xu Zhang in International Journal of Immunopathology and Pharmacology</p
sj-tif-1-iji-10.1177_20587384211065893 – Supplemental Material for Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma
No full textSupplemental Material, sj-tif-1-iji-10.1177_20587384211065893 for Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma by Chenfeng Wang, Yan Huang, Xin Ma, Baojun Wang and Xu Zhang in International Journal of Immunopathology and Pharmacology</p
Phenolic compounds‐mediated biosynthesis of gold nanoparticles and evaluation of their bioactivities: A review
No full text
Wen hua shi ying dui gan zhi de ying xiang: bian hua gan zhi, xin qi mu biao jian ce he xu huan mo shi shi bie de san fang mian de zheng ju
No full textXu, Yi.Thesis Ph.D. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 48-54).Abstracts also in Chinese.Title from PDF title page (viewed on 05, January, 2017).Xu, Yi
Cyanidin-3-O-Glucoside Supplement Improves Sperm Quality and Spermatogenesis in a Mice Model of Ulcerative Colitis
No full textImpaired fertility and low sperm quality are the global health problem with high attention. It has been noted that inflammation may impact fertility by affecting testicular spermatogenesis. Cyanidin-3-O-glucoside is a natural functional pigment with various health benefits. Nevertheless, studies on the mechanism by which C3G protects male reproduction in mice with ulcerative colitis remain scarce. The purpose of this study is to illustrate the potential mechanism of C3G for improving impaired fertility caused by colitis. A DSS-induced colitis model was applied to assess the effects of sperm quality with colitis and the health benefit role of C3G. Results indicated that C3G-treated mice exhibited higher body weight, longer colon length, less crypt damage and focal inflammation infiltration. Being consistent with that, low sperm count, low testis weight, high inflammation levels and abnormal thickness of seminiferous epithelium also observed in the DSS group were significantly recovered upon C3G treatment. These findings suggested that colitis has a close link to impaired fertility. Further analysis found that C3G could significantly suppress the inflammatory mediators in serum. Results conjointly indicated that C3G might improve the impaired fertility of mice with colitis by inhibiting inflammatory cytokines through the blood–testis barrier. C3G could be a promising daily supplement for ameliorating impaired fertility caused by colitis
Data For "Recommending Scientific Datasets Using Author Networks in Ensemble Methods"
No full textData for paper "Recommending Scientific Datasets Using Author Networks in Ensemble Methods" which is accepted by Data Science Journal. These data contains 1)MAKG (Microsoft Academic Knowledge Graph) co-author network (HDT/RDF format), 2)MAKG paper/dataset title collection (HDT/RDF format), 3) MAKG paper/dataset abstract collection (HDT/RDF format)
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