3,650 research outputs found
Cyberbase Gradignan (documents)
No full textDocuments et travaux portant sur le corpus “Cyberbase Gradignan
Cyberbase Gradignan
No full textLe corpus 'Cyberbase Gradignan' a été recueilli de juillet 2010 à juin 2012 dans le cadre de l'expérimentation Cyber-base®Justice mise en œuvre la Maison d'Arrêt de Gradignan et finalisée à l'accès à l'information, à l'apprentissage de l'informatique et à l'enseignement. Il est constitué d'enregistrements audiovisuels portant, d'une part, sur les activités dans l'espace informatique de la Maison d'Arrêt et, d'autre part, sur des entretiens avec les différents acteurs. L'ensemble du corpus a d'abord été segmenté et indexé (l'indexation, à la fois contextuelle et thématique, a été reportée dans les noms de fichiers). Une partie des séquences a ensuite été transcrite et annotée
B regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesis
No full text
The inflammatory cytokine TNF-α has been recognized as a critical tumor promoter, but the effector cells that mediate its action have not been fully characterized. Because B cells regulate squamous and prostate carcinogenesis, and
Tnf
−/−
mice harbor B-cell defects, we investigated the hypothesis that B cells are important effector cells for TNF-α–mediated promotion of cancer development. Using an adoptive transfer strategy and the 7,12-dimethylbenz[α]anthracene/terephthalic acid (DMBA/TPA) two-stage model of skin carcinogenesis, we found that both B cells and TNF-α are critical for the development of DMBA/TPA-induced papilloma. Transfer of B cells from DMBA/TPA-treated wild-type mice to
Tnf
−/−
mice rescued papilloma development to a wild-type level, a result not observed when B cells from
Tnf
−/−
mice were transferred to
Rag2
−/−
mice or when TNF-α was eliminated selectively in B cells. Resistance to papilloma development in
Tnf
−/−
mice was associated with increased IFN-γ and CD8
+
T cells in skin and a significant reduction in IL-10–producing B regulatory cells alongside an increase in IFN-γ–producing CD8
+
T cells in the spleen. These data indicate that during DMBA/TPA-induced squamous carcinogenesis TNF-α mediates tumor-promoting activity via regulatory B cells that repress antitumor immunity.
</jats:p
Collecting Cures in an Artisanal Manuscript: Practical Therapeutics and Disease in Ms. Fr. 640
No full textScattered throughout Ms. Fr. 640, the forty medical recipes form a small percentage of its over 900 entries. A consideration of the ailments, ingredients, and making processes described in the manuscript, as well as the author-practitioner’s process of collecting information, reveals a variety of connections between Ms. Fr. 640’s medical recipes and early modern artisanal work
Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
No full textSummary: In a multi-level “deconstruction” of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim was to understand how six of these extracellular matrix (ECM) molecules, COL11A1, cartilage oligomeric matrix protein, FN1, versican, cathepsin B, and COL1A1, are upregulated in cancer. Using biopsies, we identified significant associations between TGFβR activity, Hedgehog (Hh) signaling, and these ECM molecules and studied the associations in mono-, co-, and tri-culture. Activated omental fibroblasts (OFs) produced more matrix than malignant cells, directed by TGFβR and Hh signaling cross talk. We “reconstructed” omental metastases in tri-cultures of HGSOC cells, OFs, and adipocytes. This combination was sufficient to generate all six ECM proteins and the matrisome expression signature. TGFβR and Hh inhibitor combinations attenuated fibroblast activation and gel and ECM remodeling in these models. The tri-culture model reproduces key features of omental metastases and allows study of diseased-associated ECM
FONDUE-FR-PRINT-16 - Transcriptions of French 16th c. prints
No full text<p>HTR Groundtruth for French 16th c. prints, produced with <a href="https://github.com/mittagessen/kraken">Kraken</a> and <a href="https://gitlab.com/scripta/escriptorium">eScriptorium</a>.</p>
<p>Original data is available on <a href="https://github.com/FoNDUE-HTR/FONDUE-FR-PRINT-16">GitHub</a>.</p><pre>@misc{FONDUE_FR_PRINT_16,
author = {Gabay, Simon},
title = {FONDUE-FR-PRINT-16},
year = {2024},<br> publisher={Zenodo}<br> url={<a href="../doi/10.5281/zenodo.11526149">https://zenodo.org/doi/10.5281/zenodo.11526149</a>}<br> doi={<a href="../doi/10.5281/zenodo.11526149">10.5281/zenodo.11526149</a>}<br>}</pre>
Temporal sequence and cellular origin of interleukin-2 stimulated cytokine gene expression
No full textHuman interferons inhibit experimental metastases of a human melanoma cell line in nude mice
No full text- …
