866 research outputs found
La fatica dei concetti. Ipermodernità, postmoderno, realismo
No full textReplica alle recensioni di Valentino Baldi, Florian Mussnug,, Giacomo Tinelli a Ipermodernità, raccolte e introdotte da Niccolò Scaffai nella sezione In discussione di «Between», Vol 4, N° 8 (2014) [http://ojs.unica.it/index.php/between/issue/current/showToc
Modelling of in vivo LIPUS stimulation of murine intestinal wall
No full textLow Intensity Pulsed Ultrasound could enable a 'wireless biopsy' of gut diseases such as ulcerative colitis, by triggering the release of pathology-characterizing molecules from the intestinal wall cells. Prior to the in vivo validation, the prediction of the acoustic propagation through living tissues results fundamental to guide the design of the experimental setting and to be able to reach the target with the desired ultrasound regime. In this work we propose a simulation framework able to precisely predict the ultrasound dose at the target (i.e., mouse colon) for the above-mentioned application
Expression of p21 in non small cell lung cancer relationship with PCNA
No full textThe first cyclin dependent kinase inhibitor to be discovered was the p21 cdk interacting protein (a.k.a., WAF1, Cip1, CAP20, Sdi1, mda6). p21 expression may or may not be dependent on p53. This pathway also inhibits DNA replication by merit of p21's interaction with PCNA, but it has also been shown that this same inhibitory interaction with p21 does not affect PCNA DNA repair abilities. We assessed the immunohistochemical expression of p21 protein in 60 curative surgical resected non small cell lung cancers relating it to the expression of PCNA to clarify the contribution of the p21/PCNA pathway to the development of NSCLC. We did not find any relationship between PCNA and p21 expression. This last result may indicate that the mechanism by which PCNA controls the DNA repair is the most important activity of this protein during lung cancer progression and development, compared to its contribution to cell proliferation. In fact, this last event is strongly counteracted by p21 expression, which in this last case works as an inhibitor of PCNA expression. In conclusion this study highlighted the important role of the p21/PCNA pathway in lung carcinogenesis, pointing out the contribution of PCNA to the response to lung aggression and not only it's role as a proliferation index. Therefore, these results offer a background to further study to evaluate potential novel therapeutic approaches to lung cancer treatment
Colonic type adenocarcinoma of male urethra
No full textA case of rare primary adenocarcinoma of the bulbomembranous portion of the male urethra is presented. The histological and immunohistochemical characteristics of this tumor are identical to those of colon adenocarcinomas. The pathogenesis can be explained either by neoplastic degeneration of globet cells found in the urethral epithelium or by malignant degeneration of persistent glandular elements that are embryonal residues. The patient was successfully treated with transurethral prostatectomy and with a high dose of radiation therapy
Intrapulmonary teratoma associated with thymic tissue
No full textA case of benign, cystic intrapulmonary teratoma occurring in the right lobe of a 22-year old female is described with grossly and microscopically findings. The connection between the tumor and the segmental bronchus, together with the absence of germ cell neoplasms in other locations, clearly established the true intrapulmonary nature of the lesion. The unusual finding of thymic tissue within the wall supports the possible origin from the third pharyngeal pouch
Corrado Cagli. Transatlantic bridges, 1938-1947
No full textIn the 1930s the young Italian artist, Corrado Cagli was a rising star of the Scuola Romana, supported by the Fascist regime despite being both Jewish and a homosexual. Following the Racial Laws, he fled first to Paris, and then to the USA, where he remained until 1947. Raffaele Bedarida’s new book, Corrado Cagli – La pittura, l’esilio, l’America (1938-1947) Donzelli Editore, 2018 (soon to be translated into English by CPL Editions), focuses on Cagli’s American exile.
While examining Cagli in the context of the artistic and intellectual migration from Europe to the US, Bedarida provides valuable new insight into the specific plight of this Italian Jewish artist, once championed by Fascism and into the complexities of the use of art for cultural diplomacy.
The author combines biography, cultural history, and critical analysis in exploring a decisive period in the life and work of a painter whose complex personality and non-signature style, defy classifications. The book also provides thought-provoking and nuanced arguments on the ideologically based ostracism that Cagli encountered upon returning to Italy in the immediate aftermath of the war. Because of his past as a former regime-endorsed artist, his recent American success, his participation in the liberation of Europe from Nazi-Fascism with the American army, and Jewish exile, Cagli simply did not fit into any of the faction of Italy’s post-war heated cultural disputes.
Based on extensive original research and written with brio, Bedarida’s book is an essential contribution to a growing field of studies that examine how, by welcoming artist and intellectuals in flight from Nazi-Fascism, the United States had been given what Will Norman has called “custodianship for a civilization.
Proceedings of the LREC 2020 workshop on Resources and Techniques for User and Author Profiling in Abusive Language (ResT-UP 2020)
No full textThis volume documents the Proceedings of the 1st Workshop on Resources and Techniques for User and Author Profiling in Abusive Language (ResT-UP), held online on 12 May 2020 as part of the LREC 2020 conference (International Conference on Language Resources and Evaluation).
The workshop aimed at bringing together researchers and scholars working on author profiling and automatic detection of abusive language on the Web, e.g., cyberbullying or hate speech, with a twofold objective: improving the existing LRs, e.g., datasets, corpora, lexicons, and sharing ideas on stylometry techniques and features needed for profile information extraction and classification. ResT-UP targeted Profiling scholars and research groups, experts in Statistic and Stylistic Analysis of texts as well as computational linguists who investigate author profile and personality both in short texts (social media posts, blog texts and email) and in long texts (such as pamphlets, (fake) news and political documents). ReST-UP represented an opportunity to share profiling experiments with the scientific community and to show automatic detection techniques of abusive language on the Web. Despite the cancellation of LREC 2020 due to the COVID-19 international emergency, ResT-UP was organized online on Microsoft Teams on May 12th 2020 and the programme included three oral presentations and featured an invited talk by Paolo Rosso. ResT-UP was attended by about fifty representatives of academic and industrial organisations
Expression of AP-2 transcription factor and of its downstream target genes c-kit, E-cadherin and p21 in human cutaneous melanoma
No full textThe AP-2 transcription factor plays a pivotal role in regulating the expression of several genes involved in tumor growth and progression of melanoma. We determined, by Western blot, variation in the level of expression of AP-2 and three of its downstream targets, c-kit, E-cadherin, and p21 in several human melanoma cell lines and, by immunohistochemistry, in a group of 99 histological samples including benign and malignat melanocytic lesions. A significant negative correlation between AP-2 expression level and tumor thickness was found. Moreover, AP-2 expression was positively associated with E-cadherin and c-kit expression. In contrast, there was a significant negative association between AP-2 and p21 expression levels. These findings suggest that p21 is independent of AP-2 transactivator function during the latest phases of melanoma progression. Finally, AP-2, c-kit, E-cadherin, and p21 expression levels did not show to be able to distinguish between dysplastic nevi and nevi without dysplasia. We conclude that changes in the expression of these proteins are involved in the later phases of melanoma progression, and may be responsible for the transition from local invasive melanoma to metastasis. © 2001 Wiley-Liss Inc
Hierarchical Forecasting of Italian Mortality Data with Gender and Cause of Death Reconciliation
No full textWe introduce a novel approach that integrates Compositional Data Analysis (CoDA) with forecast reconciliation to improve mortality projections disaggregated by cause of death and demographic groups. By leveraging the hierarchical and grouped structures inherent in causes-of-death mortality data, our framework addresses key challenges in mortality forecasting, ensuring internal coherence across different levels of aggregation while maintaining a high degree of predictive accuracy. Our empirical results on Italian cause-specific mortality data, extracted from the WHO Database, demonstrate that forecast reconciliation significantly enhances the reliability of projections. Furthermore, the MinT approach consistently outperforms alternative methods, particularly for top-level mortality forecasts. Our study highlights the substantial benefits of combining CoDA with forecast reconciliation, with broad implications for demographic research, public health planning, and actuarial assessments
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