1,191 research outputs found
Prototype of Multiplex Bead Assay for Quantification of Three Serum Biomarkers for In Vitro Diagnosis of Endometriosis
No full textEndometriosis is a very common disease, affecting 10% of women in the reproductive age. To date, a significant delay between onset of the symptoms and definitive diagnosis is caused by the lack of a reliable non-invasive diagnostic test. Recently, the potential value as diagnostic markers for endometriosis of three proteins (Zn-alpha2-glycoprotein, serum albumin, and complement C3 precursor), has been showed. In this article, we have defined the experimental conditions for the development of a multiplex bead array assay for rapid and simultaneous quantification of these three biomarkers in the serum of patients with endometriosis. Finally, pivotal experiments on a small cohort of patients have confirmed the diagnostic value of this assay. J. Cell. Physiol. 231: 2622–2627, 2016. © 2016 Wiley Periodicals, Inc
Elastic anomalies at terahertz frequencies and excess density of vibrational states in silica glass
No full textWe study the temperature dependence of acousticlike excitations measured by means of inelastic x-ray scattering at terahertz frequencies in silica glass. The apparent sound velocity shows, between 300 and 1600 K, the same temperature variation measured, at lower frequencies, by Brillouin light scattering. On the contrary the vibrations at the boson peak (BP) present a much stronger temperature dependence, as indicated by neutron scattering data. The measured dispersion and damping are used to compute the contribution to the vibrational density of states (VDOS) coming from the propagating acousticlike modes. This part of the VDOS accounts only for a fraction of the BP intensity, indicating that other kinds of excitation accumulate in this frequency range. It is consequently not surprising that the BP does not follow the temperature evolution of the Debye frequency, which describes the modification of the continuum medium. Finally we present a comparison between the experimentally accessible quantities and a recently proposed model for the vibrations in glasses, based on the assumption of random spatial variations of the shear modulus [Schirmacher, Europhys. Lett. 73, 892 (2006)]
PNRR e Città Metropolitane. La sfida dei Piani Urbani Integrati
No full textE’ passato quasi un decennio dall’entrata in vigore della legge 56/2014, che dopo molti tentativi andati a vuoto istituiva le Città Metropolitane: enti intermedi, di secondo livello, che ereditavano i confini e le strutture delle vecchie province, ma che avrebbero dovuto svolgere nuovi ruoli. Attraverso la legislazione regionale e la propria autonomia statutaria e organizzativa, i nuovi enti sono andati sviluppandosi in direzioni diverse, a tratti ambigue, a cavallo fra government e governance, con maggior o minore capacità di istituzionalizzarsi come interlocutori e mediatori stabili e autonomi nei processi di policy territoriali. Su questo percorso fragile e incerto di istituzionalizzazione si innesta il PNRR, con un intervento che investe direttamente e massicciamente le Città metropolitane: i Piani Urbani Integrati (PUI). Questi mettono a disposizione quasi tre miliardi di euro, ripartiti in maniera non competitiva fra gli enti metropolitani, per il miglioramento della qualità del decoro urbano e del tessuto sociale, economico e ambientale, e per la riduzione delle situazioni di emarginazione e degrado. Il volume analizza il processo di elaborazione e i contenuti dei PUI, attraverso uno studio documentale di tutti i quattordici casi a livello nazionale e tre studi di caso approfonditi nelle Città Metropolitane di Bologna, Milano e Reggio Calabria. La ricostruzione dei contesti politici e istituzionali, la comparazione con le precedenti esperienze di programmazione e pianificazione territoriale, e lo studio dei processi decisionali e dei loro esiti permettono di indagare a che punto sia arrivata l’istituzionalizzazione di questi enti e come il PNRR possa essere fattore di consolidamento oppure di rottura del loro fragile equilibrio politico-amministrativo
Metropolitan cities in search of identity: Challenges and opportunities for urban strategic planning in Italy’s National Recovery and Resilience Plan
No full textThis article explores the interplay between Integrated Urban Plans (IUPs), introduced by Italy’s post-Covid National Recovery and Resilience Plan (NRRP), and Metropolitan Cities (MCs) established in 2014 and still pursuing institutionalization. We investigate if IUPs empower MCs as innovative strategic bodies through their direct engagement in urban regeneration. Drawing from institutionalization theory, we analyze documents and interviews from three selected MCs. Findings reveal: diverse approaches to IUPs; varying success in aligning projects with strategic missions; and distinct MC models and degrees of consolidation, shaped by legacies and
capacities. The NRRP proves an effective window of opportunity for the institutionalization of MCs
Vibrational Dynamics of Non-Crystalline Solids
No full textThe boson peak (BP) is an excess of vibrational states over the Debye law appearing at terahertz frequencies. It is found in all glasses and marks the crossover between the long-wavelength behavior, where the solid can be considered as an isotropic continuum, and the region where the wavelength of the sound wave starts to experience the microscopic details of the structure. This chapter is devoted to a review of the main experimental observations regarding the vibrational dynamics of amorphous solids, as detected by neutron and X-ray scattering techniques. A first part of the chapter is devoted to the measurements of the BP and its evolution as a function of external parameters, such as temperature, pressure, or density. The second part of the chapter reviews the wavevector evolution of the dynamic structure factor, which provides evidence of a pseudo-acoustic propagating mode up to frequencies comparable to those of the BP. This longitudinal mode has a sound attenuation which follows ..
Fine morphology of the myrmecophilous larva of Paussus kannegieteri (Coleoptera: Carabidae: Paussinae: Paussini). Corresponding author
No full textFIGURES 13–18. Paussus kannegieteri third instar larva: 13, thorax, left lateral view; 14, thorax, dorsal view; 15, mesothoracic spiracle; 16, metathoracic spiracle-like structure; 17, mesothoracic leg, anterolateral view; 18, apex of metathoracic leg with lanceolate setae, posterolateral view. CO = coxa, ls = lanceolate setae, m = membrane, ME = mesonotum, MT = metanotum, pe = peritreme, PR = pronotum, un = claw. Scale bars: Figs. 13–14 = 500 µm; Fig. 15 = 10 µm; Fig. 16 = 20 µm; Fig. 17 = 200 µm; Fig. 18 = 50 µm.Published as part of Giulio, Andrea Di, 2008, Fine morphology of the myrmecophilous larva of Paussus kannegieteri (Coleoptera: Carabidae: Paussinae: Paussini), pp. 37-50 in Zootaxa 1741 on page 44, DOI: 10.5281/zenodo.18152
Novel dietary supplement association reduces symptoms in endometriosis patients
No full textEndometriosis is characterized by disabling symptoms that afflict young women with severe physical discomfort, difficulty in relationship life, and infertility; however, the currently available therapeutic strategies are unsatisfactory. Goal of this research was to identify a new combination of natural active ingredients that, administered as dietary supplements, could have the effect of reducing inflammatory response in endometriosis patients, decreasing the symptoms the disease produces and its harmful effects on affected organs. A cohort of endometriosis patient was treated for three months with a composition including quercitin, curcumin, parthenium, nicotinamide, 5-methyltetrahydrofolate and omega 3/6. Using a VAS scale, we demonstrated a significant reduction of the symptoms in endometriosis patients treated with the dietary composition respect to the controls. Moreover, we demonstrated also a significant reduction in the serum levels of PGE2 and CA-125. Further study are required to compare the effect of this combination of molecules with standard therapies and to evaluate if the use of these dietary supplements in combination with standard therapies may lead to the improvement of the regular medical treatment for endometriosis. This article is protected by copyright. All rights reserved.Endometriosis is characterized by disabling symptoms that afflict young women with severe physical discomfort, difficulty in relationship life, and infertility; however, the currently available therapeutic strategies are unsatisfactory. Goal of this research was to identify a new combination of natural active ingredients that, administered as dietary supplements, could have the effect of reducing inflammatory response in endometriosis patients, decreasing the symptoms the disease produces and its harmful effects on affected organs. A cohort of endometriosis patient was treated for 3 months with a composition including quercitin, curcumin, parthenium, nicotinamide, 5-methyltetrahydrofolate, and omega 3/6. Using a VAS scale, we demonstrated a significant reduction of the symptoms in endometriosis patients treated with the dietary composition respect to the controls. Moreover, we demonstrated also a significant reduction in the serum levels of PGE2 and CA-125. Further study are required to compare the effect of this combination of molecules with standard therapies and to evaluate if the use of these dietary supplements in combination with standard therapies may lead to the improvement of the regular medical treatment for endometriosis
Expression of apoptosis-related markers in malignant epithelial tumours of the lacrimal gland and their relation to clinical outcome.
No full textSound Attenuation at Terahertz Frequencies and the Boson Peak of Vitreous Silica
No full textThe propagation and damping of the acoustic excitations in vitreous silica is measured at terahertz frequencies using inelastic x-ray scattering. The apparent sound velocity shows a marked dispersion with frequency while the sound attenuation undergoes a crossover from a fourth to a second power law frequency dependence. This finding solves a recent controversy concerning the location of this crossover in vitreous silica, clarifying that it occurs at the position of the glass-characteristic excess of vibrational modes known as boson peak, and thus establishing a direct connection between boson peak and acoustic dispersion curves
Archivio storico della provincia di Salerno. A.6, n.1/3(1927)
No full textA.6,n.1(1927): Baldi R., Controversie politiche ed economiche fra salernitani, cavesi ed anche amalfitani, P.3-22; Bilotti P. E., Di un antico tempio in Castiglione, P.23-33; Sorrentino A., Continuazione della Cronaca di Antonio Stassano (parte 2.ed ultima), P.34-62; I Geografi italiani e il loro 10. Congresso, P.63-66.A.6,n.2/3(1927): De Angelis M., «L'arte dei barbari». Vicende dell'arte italiana, dal Duecento al Quattrocento, P.69-174; Della Corte M., Pompei e i cristiani, P.175-178; Baldi R., La patria e la famiglia di Giulio Genoino, P.179-186
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