26 research outputs found
The problem of the „male“ language (on works by Miglena Nikolchina and Irena Ivanova)
Full text linkThe paper is devoted to the problem of the „male“ language which can be found in the works of two Bulgarian poets – Miglena Nikolchina and Irena Ivanova (better known by her pseudonym Rene Karabaš). The author associates them with the change that happens in literary criticism and the literary production itself after the 1990s. The author considers the synthesis of poetry and prose, poetry and theory as an intertextual „dialogue” through which is possible to analyze the texts of both poets. Thematically, the article focuses on the ways in which the woman gains „a right to have a voice“ rejecting her gender to take up the poet’s word and on how man appears to be a „quotation” in their works
Oral allergy syndrome as a manifestation of food allergy.// Орален алергичен синдром като проява на хранителна алергия
No full text[EN] The dissertation “Oral allergy syndrome as a manifestation of food allergy” studies the orofacial manifestations of food allergy, clarifies the role of food allergens in the development of oral allergy syndrome, and explores the relationship of the syndrome with cross reactivity to basic atopic allergens (pollens). The most typical clinical symptoms of the syndrome are defined through medical history. These are erythema and edema of the tongue, edema of the uvula and the larynx, and oral erythema and enanthema. The most common subjective complaints are oropharyngeal pruritus and burning of the lips. The foodstuffs that most frequently trigger oral allergy syndrome are determined – fresh fruits, eggs and milk. The degree of sensitization to relevant food and pollen allergens is investigated by means of clinical and laboratory methods and very big to functional positive correlation is registered in sensitization to birch, apple and hazelnut allergens. The relationship between the oral status (dental and hygiene), the use and subsequent sensitization to dental materials and the oral allergic symptoms is also examined. It is defined as weak. A protocol of studies and safety measures is offered concerning work with patients allergic to foodstuffs in dental surgeries.Дисертационният труд „Орален алергичен синдром като проява на хранителна алергия“ проучва орофациалните прояви на хранителна алергия, изяснява мястото на хранителните алергени в развитието на оралния алергичен синдром и изследва връзката му с кръстосаната реактивност към основни атопични алергени (полени). Анамнестично се определят най-характерните прояви на синдрома – еритем и оток на езика, оток на увулата и ларинкса, орален еритем и енантем, както и най-честите субективни оплаквания – сърбеж в гърлото и парене на устните. Дефинират се храните, които най-чесо го провокират – пресни плодове, яйца и мляко. С помощта на клинични и лабораторни методи се изследва степента на сенсибилизация към съответните хранителни и поленови алергени и се доказва много голяма до функционална корелация при сенсибилизация към алергените на бреза, ябълка и лешник. Търси се и връзката на оралния статус (зъбен и хигиенен), употребата и последващата сенсибилизация към дентални материали с оралната алергична симптоматика. Определя се като слаба. Предлага се протокол от изследвания и мерки за безопасна работа при пациенти с хранителна алергия в денталните практики
FOOD ALLERGY AND ORAL ALLERGY SYNDROME. Part I. A review.
No full textFood allergy and intolerance are wide spread nowadays. However, the problem existed and was registered and described still by the ancients. It was fully understood and scientifically depicted in the 20th century after IgE and anaphylaxis were discovered, new diagnostic tests were initiated and the term “allergy” was introduced. There are some interesting aspects of the problem. Epidemiology is the first one – in the last two decades the number of people suffering from food allergy increased significantly and reached 4% of the population. Food allergy covers all ages, both sexes; atopic people and these with other allergic or digestive diseases are in the risk group also. There is certain influence of the eating habits as well. Etiology is rich and varied. It includes all foodstuffs of plant and animal origin, spices, honey, medicinal products - milk, eggs, meat, fish, nuts, fruits and vegetables, etc. Pathogenesis is complex
FOOD ALLERGY AND ORAL ALLERGY SYNDROME. Part II. A review.
No full textFood allergies differ from other allergic diseases through the variety of symptoms (some of them serious) they induce – skin and mucosal symptoms, digestive and respiratory symptoms, anaphylaxis and anaphylactic shock. The most interesting one for us, as dentists, is oral allergy syndrome. Diagnosis associates skin testing, specific IgE assays and, in most cases, oral challenge tests. Treatment is difficult and depends on the patient’s symptoms. Very important for our everyday practice is the existence of cross reactions between foods and specific medical and dental products and materials
ARE WE ALLERGIC TO OUR WORK
Full text linkDental materials and medicines possess high allergic potential. They provoke different allergic reactions in patients and staff. The sensibilization of the staff begins still in the dental school. There are several risk groups – the atopic individuals and these with other allergies. The aim of the study is to follow up the development and the connection between the allergic state and the professional etiology and to determine whether allergy is an obstacle for studying and practicing dental medicine
Genomic Tests Guiding the Adjuvant Systemic Therapy in Women with Breast Cancer
No full textIntroduction: The decision to initiate adjuvant chemotherapy after surgery in patients with estrogen receptor-positive and lymph node-negative early stage breast cancer, has traditionally been guided by clinical and pathological factors (characteristics of the patient and the tumor), in conjunction with the clinician`s and the patient`s preferences. Many of these patients are exposed to adjuvant chemotherapy toxicity and cost with little or no clinical benefit, and identifying those who do benefit, remains a challenge. Gene-expression profiling is an emerging clinical strategy which evaluates cancer recurrence risk by using genomic information in order to support better decision-making about adjuvant chemotherapy.Materials and Methods: In this research we analyzed three types of gene-expression-profiling tests of breast cancer. A multigene immunohistochemistry-based test, known as MammoStrat, classifies breast cancer patients into low-, moderate- or high-risk categories for disease recurrence. The MammaPrint assay is a seventy-gene signature developed using tumor tissue from young women (less than fifty-five years of age) with node-negative disease. OncotypeDX is a twenty-one-gene-expression profiling that provides a probability of recurrence score for women with early stage (Stage I or II), estrogen receptor-positive, node-negative breast cancer, and categorizes patients as low-, intermediate- , or high- risk for distant metastasis in the next five to ten years.Results: A high-risk result is correlated with distant breast cancer recurrence rate, hormone therapy benefit, and chemotherapy benefit. A lower score is correlated with a lower risk of distant breast cancer recurrence, lower benefit of chemotherapy, and greater benefit of hormone therapy.Conclusion: Use of gene-expression profiling along with clinical and pathological classification of early-stage breast cancer provides the physician with additional information about adjuvant systemic therapy in these patients in order to maximize efficacy and minimize adverse side effects
Prevention of the malocclusions of children with prematurely extracted teeth. Spacemaintainers- types and indications
Full text linkЗапазването на място се налага във временно и смесено съзъбие, за да се предотврати скъсяването на зъбната дъга. Използването на местопазители при преждевременна загуба на временни зъби във временно и смесено съзъбие в подходящото време може да профилактира последиците от скъсяването на зъбната дъга и нуждата от комплексно ортодонтско лечение в по-късен етап. Целта на настоящия обзор е подробно да се разгледат видовете местопазители, техните предимства и недостатъци. Профилактичните мероприятия при преждевременната загуба на временните зъби са преди всичко детските протезни конструкции - местопазителите.Preserving a place in the denture is necessary in order to prevent shortening of the dental arch in the temporary and mixed dentition. Using space maintainers, in the cases of an early tooth lost in temporary and mixed dentition at the right time, could prevent the effects of the shortening of the dental arch and the need for comprehensive orthodontic treatment in the future. The aim of this review is to examine the types of space maintainers, their advantages and disadvantages. Preventive measures in premature loss of temporary teeth are mainly children's prosthetic constructions - the space maintainers
Oral Manifestation of Systemic Diseases
No full textIntroduction: The oral cavity, apart from being the beginning of the gastrointestinal tract and playing a role in the speech, can also be a basis for symptoms, connected with systemic diseases. The most serious problems concerning dental professionals include caries, oral ulcers, mucosal erythema, gingival bleeding and hypertrophy, soft tissue exophytic masses, dry mouth, facial pain, movement disorders, tooth abnormalities, abnormal dental wear, tooth/mucosal discoloration, developmental and bone pathology.Materials and Methods: Oral manifestations of systemic diseases can be evaluated through a variety of methods. Careful examination of the oral cavity is still the most important procedure. It may reveal mucosal changes, periodontal inflammation and bleeding, and the general condition of the teeth. Biopsy is an obligatory method for diagnosing cancer and precancerous lesions. Even then, there is a possibility for a mistake. The function of oral organs is assessed as a malfunction may indicate an unnoticed until now health problem. Pain symptoms should never be underestimated.Results: Dental specialists should have in mind that even the smallest irregularity may be connected to an undiagnosed systemic disease. Oral ulceration may be found in patients with lupus erythematosus, pemphigus vulgaris, or Crohn`s disease. Severe periodontal inflammation or bleeding should prompt investigation of conditions such as diabetes mellitus, human immunodeficiency virus infection, thrombocytopenia, and leukemia. An understanding of the relationship between systemic disease and oral pathology is important with respect to establishing the diagnosis and determining the complexity of the following treatment.Conclusion: Careful examination of the oral cavity may reveal findings indicative of an underlying systemic condition, and allow for early diagnosis and treatment. All fields of medicine should work together in the best interest of patients.
